The non-human primate model of endometriosis: research and implications for fecundity

A G Braundmeier; Andrea Braundmeier; Asgerally T. Fazleabas; A T Fazleabas

doi:10.1093/molehr/gap057

The non-human primate model of endometriosis: research and implications for fecundity

A G Braundmeier, Andrea Braundmeier, Asgerally T. Fazleabas, A T Fazleabas

Molecular human reproduction · 2009 · vol. 15(10) , pp. 577–586 · doi:10.1093/molehr/gap057 · PMID:19633013 · PMC2744471 · W2038607305

review OA: bronze CC0 ⤵ 59 in-corpus citations

📄 Open PDF View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This review summarizes findings on endometriosis development, progression, and therapeutic targets using an experimental baboon model to understand disease-associated subfertility.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertility Animals Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Fertility Primates Uterus Uterus Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

europepmc: last seen: 2026-06-13T06:22:48.782012+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:13:59.677786+00:00

License: CC0 · commercial use OK

[1] Adhesion of shed menstrual tissue in an in-vitro model using amnion and peritoneum: a light and electron microscopic study via openalex

[2] Alterations in the Calcitonin and Calcitonin modulated proteins, E-cadherin and the enzyme tissueTransglutaminase II during the window of implantation in a baboon model of endometriosis via openalex

[3] Alterations in the Calcitonin and Calcitonin Modulated Proteins, E-Cadherin and the Enzyme Tissue Transglutaminase II during the Window of Implantation in a Baboon Model of Endometriosis via openalex

[4] Altered maturation and function of peritoneal macrophages: Possible role in pathogenesis of endometriosis via openalex

[5] A Modified Baboon Model for Endometriosis via openalex

[6] Animal Studies in Endometriosis: A Review via openalex

[7] Aromatase expression in endometriosis via openalex

[8] Aromatase expression in endometriosis. via openalex

[9] Clinical relevance of the baboon as a model for the study of endometriosis via openalex

[10] Combination medical and surgical therapy for infertile patients with endometriosis. via openalex

[11] Combination Medical and Surgical Therapy for Infertile Patients with Endometriosis via openalex

[12] Comparison of c-DNA microarray analysis of gene expression between eutopic endometrium and ectopic endometrium (endometriosis) via openalex

[13] Current Concepts in the Pathogenesis of Endometriosis via openalex

[14] Deficiency of Immunophilin FKBP52 Promotes Endometriosis via openalex

[15] Deficient 17 -Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17 -Estradiol via openalex

[16] Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex

[17] Differential expression of claudins in human endometrium and endometriosis via openalex

[18] DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection via openalex

[19] Dynamic aspects of endometriosis in a mouse model through analysis of implantation and progression via openalex

[20] Effect of menstruation and intrapelvic injection of endometrium on inflammatory parameters of peritoneal fluid in the baboon (Papio anubis and Papio cynocephalus ) via openalex

[21] Effect of recombinant human TNF–binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons via openalex

[22] Effects of anti-TNF-mAb treatment on pregnancy in baboons with induced endometriosis via openalex

[23] Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons via openalex

[24] Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study via openalex

[25] Embryologic Theory of Histogenesis of Endometriosis in Peritoneal Pockets via openalex

[26] Endometriosis: current concepts and therapy via openalex

[27] Endometriosis in a baboon (Papio doguera). via openalex

[28] Endometriosis in the baboon. via openalex

[29] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[30] Eutopic Endometrium From Women With Endometriosis Shows Altered Ultrastructure and Glycosylation Compared to That From Healthy Controls—A Pilot Observational Study via openalex

[31] Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex

[32] Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis via openalex

[33] High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis via openalex

[34] Hormone treatment of endometriosis: The estrogenthreshold hypothesis via openalex

[35] HOX gene expression is altered in the endometrium of women with endometriosis via openalex

[36] Immunohistochemical Study of Angiogenic Factors in Endometrium and Endometriosis via openalex

[37] Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? via openalex

[38] Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? via openalex

[39] Incidence, symptoms, and signs of endometriosis in fertile and infertile women. via openalex

[40] Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis via openalex

[41] Interleukin-12 and Its Free p40 Subunit Regulate Immune Recognition of Endometrial Cells: Potential Role in Endometriosis via openalex

[42] Interleukin-12 and Its Free p40 Subunit Regulate Immune Recognition of Endometrial Cells: Potential Role in Endometriosis<sup>1</sup> via openalex

[43] Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1 via openalex

[44] In-vitro adhesion of endometrium to autologous peritoneal membranes: effect of the cycle phase and the stage of endometriosis via openalex

[45] Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts via openalex

[46] Medical management of endometriosis and infertility via openalex

[47] Medical Treatment of Endometriosis via openalex

[48] Microarray analysis provides insight into the early steps of pathophysiology of mouse endometriosis model induced by autotransplantation of endometrium via openalex

[49] Morphological and glycosylation changes associated with the endometrium and ectopic lesions in a baboon model of endometriosis via openalex

[50] Müllerianosis. via openalex

[51] Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? via openalex

[52] Pathology of endometriosis. via openalex

[53] Pelvic inflammation induced by diagnostic laparoscopy in baboons via openalex

[54] Peritoneal ectopic lesions from women with endometriosis show abnormalities in progesterone-dependent glycan expression via openalex

[55] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[56] Pre- and Post-Surgical Management of Endometriosis via openalex

[57] Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex

[58] Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex

[59] Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1 via openalex

[60] Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells via openalex

[61] Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex

[62] Prostaglandin E<sub>2</sub>Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells<sup>1</sup> via openalex

[63] Recombinant Human TNFRSF1A (r-hTBP1) Inhibits the Development of Endometriosis in Baboons: A Prospective, Randomized, Placebo- and Drug-Controlled Study1 via openalex

[64] Regulation of HOXA-10 and its expression in normal and abnormal endometrium via openalex

[65] Release of tumor necrosis factor-α by human peritoneal macrophages in vivo and in vitro via openalex

[66] Retrograde menstruation in women undergoing chronic peritoneal dialysis. via openalex

[67] Role of Cytokines in Progression of Endometriosis via openalex

[68] Selective Progesterone Receptor Modulators (SPRMs) via openalex

[69] Spontaneous endometriosis in the Kenya baboon (Papio doguera) via openalex

[70] Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice via openalex

[71] Steroidogenic factor-1 and endometriosis via openalex

[72] Steroid receptor and aromatase expression in baboon endometriotic lesions via openalex

[73] Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity via openalex

[74] Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17β-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism via openalex

[75] Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. via openalex

[76] The Altered Distribution of the Steroid Hormone Receptors and the Chaperone Immunophilin FKBP52 in a Baboon Model of Endometriosis Is Associated With Progesterone Resistance During the Window of Uterine Receptivity via openalex

[77] The effectiveness of laparoscopic excision of endometriosis via openalex

[78] The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2-5 year follow-up via openalex

[79] The Estrogen Early Response Gene FOS Is Altered in a Baboon Model of Endometriosis1 via openalex

[80] The eutopic endometrial response to chorionic gonadotrophin is abnormal in a baboon model of endometriosis: a possible explanation for endometriosis associated implantation failure via openalex

[81] The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression via openalex

[82] The Molecular Basis for Implantation Failure in Endometriosis via openalex

[83] The pathology of endometriosis via openalex

[84] The Progesterone Receptor Coactivator Hic-5 Is Involved in the Pathophysiology of Endometriosis via openalex

[85] The SCID mouse: an experimental model for endometriosis via openalex

[86] Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5′ CpG Island in Endometriosis via openalex

[87] Transplantation of normal and ectopic human endometrial tissue into athymic nude mice via openalex

[88] Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon via openalex

[89] Vascular endothelial growth factor A and C gene expression in endometriosis via openalex

[90] Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion via openalex

[91] W2028659031 via openalex

[92] W2143715300 via openalex

[93] W2145290390 via openalex

[94] W2019601632 via openalex

[95] W2014844101 via openalex

[96] W2010311608 via openalex

[97] W2154377312 via openalex

[98] W2157560598 via openalex

[99] W2158289124 via openalex

[100] W2159228424 via openalex