Steroidogenic factor-1 and endometriosis

Serdar E. Bulun, Bulun Se, Utsunomiya H, Hiroki Utsunomiya, Lin Z, Zhihong Lin, Yin P, Ping Yin, Cheng YH, You-Hong Cheng, Mary Ellen Pavone, Mary E Pavone, Tokunaga H, Hideki Tokunaga, Elena Trukhacheva, Trukhacheva E, Erkut Attar, Attar E, Bilgin Gurates, Gurates B, Bilgin Gürateş, Magdy P. Milad, Confino E, Edmond Confino, Emily Su, Su E, Reierstad S, Scott Reierstad, Xue Q, Qing Xue
Molecular and cellular endocrinology · 2008 · vol. 300(1-2) , pp. 104–108 · doi:10.1016/j.mce.2008.12.012 · PMID:19150483 · W2060023420
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the role of Steroidogenic factor-1 (SF-1) in the development of endometriosis, examining its expression and function in endometrial cells.

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Abstract

Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertility. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes including aromatase is present in endometriosis leading to de novo estradiol synthesis. PGE(2) induces the expression of the genes that encode these enzymes. Upon PGE(2) treatment, coordinate recruitment of the nuclear receptor SF-1 to the promoters of these steroidogenic genes is the key event for estradiol synthesis. SF-1 is the key factor determining that an endometriotic cell will respond to PGE(2) by increased estradiol formation. The presence of SF-1 in endometriosis and its absence in endometrium is determined primarily by the methylation of its promoter. The key steroidogenic enzyme in endometriosis is aromatase encoded by a single gene because its inhibition blocks all estradiol biosynthesis. Aromatase inhibitors diminish endometriotic implants and associated pain refractory to existing treatments in affected women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Steroidogenic Factor 1 Dinoprostone Dinoprostone Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Female Humans Inflammation Inflammation Steroidogenic Factor 1 Transcription Factors Transcription Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (48)

Source provenance

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