Magdy P. Milad

OBJECTIVE: To characterize gynecology clinical trials over time, compare gynecology subspecialties, and analyze factors associated with early discontinuation, results reporting, and publication. METHODS: We conducted a cross-sectional anal…

Endometriosis is a chronic, hormone-dependent disease characterized by altered endometrial stromal function, but mechanistic and translational studies have been hindered by the lack of tractable human models. Here, we establish an induced p…

This study aimed to explore the performance of ChatGPT version 4.0 (GPT-4) and Gemini Advanced (Gemini) large language models (LLMs) in addressing common patient questions after gynecology surgery with regards to accuracy, relevance, helpfu…

PURPOSE OF REVIEW: Atypical endometriosis is a distinct subtype of endometriosis, characterized by specific histopathologic findings. It is thought to be a precursor lesion to endometriosis-associated ovarian cancers, particularly clear-cel…

BACKGROUND: Female Chronic Pelvic Pain (CPP) is a common, complex, and multifactorial disease that is associated with a number of non-gynecologic and gynecologic conditions. The physical symptoms associated with CPP can contribute to emotio…

INTRODUCTION: While it is well known that endometriosis places a significant burden on both patients and our healthcare system, there remains a poor understanding of how the clinical variability of endometriosis impacts this burden. Patient…

ObjectiveTo better understand the training environment in Minimally invasive Gynecologic Surgery (MIGS) among obstetrics and gynecology (OBGYN) residency programs and the educational pathway to securing an FMIGS (Fellowship in MIGS) fellows…

OBJECTIVE: To assess the cellular and molecular landscape of adenomyosis. DESIGN: Single-cell analysis of genome-wide messenger RNA (mRNA) expression (single-cell RNA sequencing) of matched tissues of endometrium, adenomyosis, and myometri…

Endometriosis and adenomyosis are closely related disorders. Their pathophysiologies are extremely similar. Both tissues originate from the eutopically located intracavitary endometrium. Oligoclones of endometrial glandular epithelial cells…

Pelvic MRI plays an important adjunctive role in the clinical workup of female infertility. Hysterosalpingography is the first line imaging modality in evaluation of female infertility, and hysterosalpingo-contrast sonography can also be us…

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into t…

PURPOSE OF REVIEW: Use of patient-reported outcome measures in clinical practice and research is becoming more prevalent and reflects initiatives to center the patient in healthcare delivery and outcomes assessment. The purpose of this revi…

PURPOSE OF REVIEW: Adenomyosis is commonly diagnosed in women of reproductive age. Interest in conservative interventions has grown as more women desire fertility preservation or avoidance of hysterectomy. This review discusses surgical and…

OBJECTIVE: To evaluate the use of an aromatase inhibitor for the treatment of endometriosis-related chronic pelvic pain. DESIGN: Retrospective analysis. SETTING: Academic medical center outpatient reproductive endocrinology clinic. PATIE…

OBJECTIVE: To present a unique case of pelvic pain. DESIGN: Case report. SETTING: Academic institution. PATIENT(S): Thirty-nine year-old with history of endometriosis presented with pelvic pain and possible adnexal mass. INTERVENTION(S)…

CONTEXT: Retinoic acid (RA) controls multiple biological processes via exerting opposing effects on cell survival. Retinol uptake into cells is controlled by stimulated by RA 6 (STRA6). RA is then produced from retinol in the cytosol. Parti…

CONTEXT: Estradiol and its nuclear receptors, estrogen receptor (ER) alpha and ERbeta, play critical roles in endometrium and endometriosis. Levels of ERbeta, due to pathological hypomethylation of its promoter, are significantly higher in …

Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertility. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes includ…