Tumor Necrosis Factor Affects Steroidogenic Factor-1 Expression in Ovarian Granular Cells Via Inducing Gene Methylation
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Abstract
Objective: The expression of SF-1 in ovarian granulosa cells is critical for follicular growth and development, and the decreased expression of SF-1 in ovarian granulosa cells under endometriosis (EMs) pathology is not clear. This study aims to investigate the mechanism of tumor necrosis factor (TNF), a factor promoting endometriosis, in regulating the promoter methylation and expression of steroidogenic factor-1 (SF-1) in ovarian granulosa cells.
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