Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis

Zhuoying Hu, Ramanaiah Mamillapalli, Hugh S Taylor
American journal of physiology. Endocrinology and metabolism · 2018 · vol. 316(3) , pp. E373–E382 · doi:10.1152/ajpendo.00244.2018 · PMID:30576245 · PMC6459299 · W2905746949
article OA: bronze CC0 ⤵ 26 in-corpus citations
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This study found that decreased circulating miR-370-3p in endometriosis patients correlates with increased SF-1 in endometriotic lesions, and miR-370-3p negatively regulates SF-1 and cell proliferation.

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Abstract

Endometriosis is a gynecologic disease common among reproductive-aged women caused by the growth of endometrial tissue outside the uterus. Altered expression of numerous genes and microRNAs has been reported in endometriosis. Steroidogenic factor 1 (SF-1), an essential transcriptional regulator of multiple genes involved in estrogen biosynthesis, is aberrantly increased and plays an important role in the pathogenesis of endometriosis. Here, we show the expression of SF-1 in endometriosis is regulated by miR-370-3p. Sera and tissue were collected from 20 women surgically diagnosed with endometriosis and 26 women without endometriosis. We found that miR-370-3p levels were decreased in the serum of patients with endometriosis while SF-1 mRNA levels were inversely upregulated in endometriotic lesions compared with respective controls. Transfection of primary endometriotic cells with miR-370-3p mimic or inhibitor resulted in the altered expression of SF-1 and SF-1 downstream target genes steroidogenic acute regulatory protein (StAR) and CYP19A1. Overexpression of miR-370-3p inhibited cell proliferation and induced apoptosis in endometriotic cells. This study reveals that miR-370-3p functions as a negative regulator of SF-1 and cell proliferation in endometriotic cells. We suggest a novel therapeutic strategy for controlling SF-1 in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis MicroRNAs Steroidogenic Factor 1 Adult Endometriosis Endometriosis Female Gene Expression Regulation Gene Knockdown Techniques Humans MicroRNAs Steroidogenic Factor 1 Steroidogenic Factor 1 Stromal Cells Stromal Cells Young Adult

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