Role of repressed microRNAs in endometriosis

Kaei Nasu, Yoko Aoyagi, Aoyagi Y, Zhu R, Ruofei Zhu, Mamiko Okamoto, Okamoto M, Mitsutake Yano, Kai K, Kentaro Kai, Kawano Y, Yasushi Kawano
Medical molecular morphology · 2021 · vol. 55(1) , pp. 1–7 · doi:10.1007/s00795-021-00303-8 · PMID:34463829 · W3197058763
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This review summarizes recent findings on aberrantly repressed microRNAs and their potential roles in the pathogenesis of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a review that examines how aberrantly repressed microRNAs (miRNAs) and related epigenetic mechanisms contribute to the pathogenesis of endometriosis, a common estrogen-dependent condition affecting reproductive-age women. It synthesizes recent findings on repressed miRNAs and summarizes their potential roles in endometriosis-associated biological processes, while explicitly framing the evidence as accumulating rather than definitive. A major caveat noted through the review format is that it compiles existing research findings rather than presenting new experimental data or establishing causal relationships. This paper is centrally about endometriosis — specifically the roles of aberrantly repressed microRNAs and epigenetic dysregulation in its pathogenesis.

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Abstract

Endometriosis is a common, estrogen-dependent benign tumor that affect 3-10% women of reproductive age, and is characterized by the ectopic growth of endometrial tissue, which is found primarily in the rectovaginal septum, ovaries, and pelvic peritoneum. To date, accumulating evidence suggests that various epigenetic aberrations, including the expression of aberrant microRNAs (miRNAs), play definite roles in the pathogenesis of endometriosis. This review summarizes the recent findings on the aberrantly repressed miRNAs, as well as their potential roles regarding the pathogenesis of endometriosis.
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WEKO3 アイテム Role of repressed microRNAs in endometriosis http://hdl.handle.net/10559/16995 http://hdl.handle.net/10559/169952c1b5edc-0ca4-4fdb-a0cb-2bf2506f4780 | 名前 / ファイル | ライセンス | アクション | |---|---|---| | role_of_repressed_micrornas_in_endometriosis.pdf | | | | table1-downregulated_mirnas.pdf | | | | figure_1r.pdf | | | アイテムタイプ | デフォルトアイテムタイプ（フル）(1) | ||||||||||||||||||||||||||||||| |---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---| | 公開日 | 2023-03-01 | ||||||||||||||||||||||||||||||| | タイトル | |||||||||||||||||||||||||||||||| | タイトル | Role of repressed microRNAs in endometriosis | ||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 作成者 | Nasu, Kaei × Nasu, Kaei × Aoyagi, Yoko × Zhu, Ruofei × Okamoto, Mamiko × Kai, Kentaro × Kawano, Yasushi × Mitsutake, Yano | ||||||||||||||||||||||||||||||| | アクセス権 | |||||||||||||||||||||||||||||||| | アクセス権 | open access | ||||||||||||||||||||||||||||||| | アクセス権URI | http://purl.org/coar/access_right/c_abf2 | ||||||||||||||||||||||||||||||| | 権利情報 | |||||||||||||||||||||||||||||||| | 権利情報 | (c) 2021, The Japanese Society for Clinical Molecular Morphology.This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00795-021-00303-8 | ||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 主題 | |||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 主題 | endometriosis | ||||||||||||||||||||||||||||||| | 主題 | |||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 主題 | microRNA | ||||||||||||||||||||||||||||||| | 主題 | |||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 主題 | pathogenesis | ||||||||||||||||||||||||||||||| | 主題 | |||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 主題 | epigenetics | ||||||||||||||||||||||||||||||| | 内容記述 | |||||||||||||||||||||||||||||||| | 内容記述 | Endometriosis is a common, estrogen-dependent benign tumor that affect 3–10% women of reproductive age, and is characterized by the ectopic growth of endometrial tissue, which is found primarily in the rectovaginal septum, ovaries, and pelvic peritoneum. To date, accumulating evidence suggests that various epigenetic aberrations, including the expression of aberrant microRNAs (miRNAs), play definite roles in the pathogenesis of endometriosis. This review summarizes the recent findings on the aberrantly repressed miRNAs, as well as their potential roles regarding the pathogenesis of endometriosis. | ||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 出版者 | |||||||||||||||||||||||||||||||| | 出版者 | Springer Nature | ||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 日付 | |||||||||||||||||||||||||||||||| | 日付 | 2022-03-01 | ||||||||||||||||||||||||||||||| | 日付タイプ | Issued | ||||||||||||||||||||||||||||||| | 言語 | |||||||||||||||||||||||||||||||| | 言語 | eng | ||||||||||||||||||||||||||||||| | 資源タイプ | |||||||||||||||||||||||||||||||| | 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | ||||||||||||||||||||||||||||||| | 資源タイプ | journal article | ||||||||||||||||||||||||||||||| | 出版タイプ | |||||||||||||||||||||||||||||||| | 出版タイプ | AM | ||||||||||||||||||||||||||||||| | 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | ||||||||||||||||||||||||||||||| | 識別子 | |||||||||||||||||||||||||||||||| | 識別子 | http://hdl.handle.net/10559/16995 | ||||||||||||||||||||||||||||||| | 識別子タイプ | HDL | ||||||||||||||||||||||||||||||| | 関連情報 | |||||||||||||||||||||||||||||||| | 関連タイプ | isVersionOf | ||||||||||||||||||||||||||||||| | 識別子タイプ | DOI | ||||||||||||||||||||||||||||||| | 関連識別子 | https://doi.org/10.1007/s00795-021-00303-8 | ||||||||||||||||||||||||||||||| | 収録物識別子 | |||||||||||||||||||||||||||||||| | 収録物識別子タイプ | ISSN | ||||||||||||||||||||||||||||||| | 収録物識別子 | 1860-1480 | ||||||||||||||||||||||||||||||| | 収録物名 | |||||||||||||||||||||||||||||||| | 収録物名 | Medical Molecular Morphology | ||||||||||||||||||||||||||||||| | 言語 | en | ||||||||||||||||||||||||||||||| | 巻 | |||||||||||||||||||||||||||||||| | 巻 | 55 | ||||||||||||||||||||||||||||||| | 号 | |||||||||||||||||||||||||||||||| | 号 | 1 | ||||||||||||||||||||||||||||||| | 開始ページ | |||||||||||||||||||||||||||||||| | 開始ページ | 1 | ||||||||||||||||||||||||||||||| | 終了ページ | |||||||||||||||||||||||||||||||| | 終了ページ | 7 |

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs Endometrium Endometrium Female Humans

Citation neighborhood

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Cited by (8)

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