Downregulation of miR-183 inhibits apoptosis and enhances the invasive potential of endometrial stromal cells in endometriosis

Xiao-Yan Shi, Xiaoyan Shi, Lin Gu, Jie Chen, Xi-Rong Guo, Xirong Guo, Ying-Li Shi, Yingli Shi
International journal of molecular medicine · 2013 · vol. 33(1) , pp. 59–67 · doi:10.3892/ijmm.2013.1536 · PMID:24173391 · W1994878657
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that miR-183 is downregulated in endometriosis tissues, where it normally inhibits endometrial stromal cell apoptosis and invasion, and its downregulation promotes cell growth and invasiveness.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper profiled microRNAs in normal, eutopic, and ectopic endometrium using miRNA microarray screening followed by qPCR validation, focusing on miR-183, which was reported as downregulated in ectopic and eutopic tissues. In cultured endometrial stromal cells (ESCs), the study used lentiviral overexpression or inhibition of miR-183-5p and found that miR-183 promotes ESC apoptosis and negatively regulates invasive ability without affecting ESC proliferation, while estradiol, progesterone, TNF-α, and IL-6 decreased miR-183 expression. A key limitation is that functional experiments were performed in vitro in ESCs with relatively constrained conditions (e.g., proliferative-phase tissue sourcing and specific hormone/cytokine doses), so in vivo relevance is not directly tested. This paper is centrally about endometriosis — it links miR-183 downregulation to apoptosis and invasion of endometrial stromal cells in endometriosis.

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Abstract

Endometriosis is a common gynecological disease, yet its pathogenesis remains poorly understood. Recent studies have demonstrated that the aberrant expression of certain microRNAs (miRNAs) may correlate with the development and progression of endometriosis. In this study, we profiled several differentially expressed miRNAs in the normal, eutopic and ectopic endometrium by miRNA microarray screening analysis, among which, miR-183 was found to be downregulated in the ectopic and eutopic tissues, and the result was further confirmed by real-time PCR (qPCR). Functional analysis indicated that miR-183 plays a promotional role in endometrial stromal cell (ESC) apoptosis and has a negative regulatory impact on the invasive ability of cells, although it has no effect on ESC proliferation. Ovarian steroids (17β-estradiol and progesterone) and inflammatory factors (tumor necrosis factor-α and interleukin-6) decreased the expression of miR-183 in the ESCs. This regulatory function may further manifest the growth and invasive potential of ESCs by altering the expression of miR-183. These findings suggest that the downregulation of miR-183 expression is involved in the development and progression of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Down-Regulation Endometriosis Endometrium MicroRNAs Stromal Cells Apoptosis Apoptosis Cell Survival Endometriosis Endometriosis Endometrium Endometrium Estradiol Estradiol Female Humans Interleukin-6 Interleukin-6 Microarray Analysis MicroRNAs

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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