MicroRNA and gynecological reproductive diseases

Xavier Santamaria, Xavier Santamaría, Hugh S. Taylor, Hugh Taylor
Fertility and sterility · 2014 · vol. 101(6) , pp. 1545–1551 · doi:10.1016/j.fertnstert.2014.04.044 · PMID:24882618 · W2133615696
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This paper discusses the role of microRNAs in gynecological reproductive diseases.

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Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gynecological diseases, cancer, inflammatory diseases, and cardiovascular disorders. Abnormal expression of miRNAs has been observed in multiple human reproductive tract diseases including preeclampsia, endometrioid endometrial adenocarcinoma, uterine leiomyomata, ovarian carcinoma, endometriosis, and recurrent pregnancy loss. In the following review, an update of the role of microRNA and gynecological diseases is performed covering, not only impact of microRNA dysregulation in the origin of each disease, but also showing the potential useful diagnostic and therapeutic tool that miRNA may play in these gynecological pathologies.

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Condition tags

endometriosis

MeSH descriptors

Genital Diseases, Female MicroRNAs Reproduction Reproduction Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Animals Endometriosis Endometriosis Endometriosis Endometriosis Female Gene Expression Regulation Genetic Markers Genital Diseases, Female Genital Diseases, Female Genital Diseases, Female Humans

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License: CC0 · commercial use OK