The Expression and Ovarian Steroid Regulation of Endometrial Micro-RNAs

Tannaz Toloubeydokhti, T. Toloubeydokhti, Qun Pan, Xiaoping Luo, Orhan Bükülmez, Orhan Bukulmez, Nasser Chegini
Reproductive sciences (Thousand Oaks, Calif.) · 2008 · vol. 15(10) , pp. 993–1001 · doi:10.1177/1933719108324132 · PMID:19088369 · PMC2729333 · W1566032609
article OA: green CC0 RETRACTED ⤵ 33 in-corpus citations
Retraction notice. Marked retracted by OpenAlex; see publisher for the formal retraction notice.
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Specific micro-RNAs were found to be aberrantly expressed in endometriosis and differentially regulated by ovarian steroids in endometrial cells.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The paper examined expression of four microRNAs (miR-17-5p, miR-23a, miR-23b, and miR-542-3p) and predicted target genes, alongside steroidogenic acute regulatory protein, aromatase, and cyclooxygenase-2, in paired ectopic endometrium (ECE) and eutopic endometrium (EUE) compared with normal endometrium (NE). Using endometrial stromal and glandular epithelial cell models, the authors found that miR-23b and miR-542-3p were lower and miR-17-5p was higher in ECE and EUE versus NE, with these miRNA levels elevated and inversely correlated with target gene expression in ECE. They also reported differential regulation of miRNAs and genes by 17β-estradiol, medroxyprogesterone acetate, the estrogen receptor antagonist ICI-182780, and RU-486 in stromal and epithelial cells. The study’s caveat is that it includes limited miRNA targets and relies on predicted gene relationships rather than comprehensive validation. This paper is centrally about endometriosis — it analyzes altered microRNA expression in ectopic endometrium and links steroid regulation and miRNA–target gene stability to endometriosis pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Gene Expression Regulation Gonadal Steroid Hormones MicroRNAs Ovary Adult Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Regulation Gene Expression Regulation Gonadal Steroid Hormones Gonadal Steroid Hormones Gonadal Steroid Hormones Humans MicroRNAs

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References (62)

Cited by (33)

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