Characterization of messenger RNA expression of estrogen receptor-α and -β in patients with ovarian endometriosis

Sachiko Matsuzaki, Matsuzaki S, S Matsuzaki, T. Fukaya, Fukaya T, Takao Fukaya, Shigeki Uehara, S Uehara, Uehara S, Murakami T, T Murakami, Takashi Murakami, H Sasano, Sasano H, Hironobu Sasano, Yajima A, A Yajima, Akira Yajima
Fertility and sterility · 2000 · vol. 73(6) , pp. 1219–1225 · doi:10.1016/s0015-0282(00)00527-6 · PMID:10856486 · W2056005603
article OA: closed CC0 ⤵ 21 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study characterized messenger RNA expression of estrogen receptor-α and -β in patients with ovarian endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo evaluate the expression of estrogen receptor (ER)-alpha and ER-beta messenger RNA (mRNA) in ovarian endometriosis.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with endometriosis and patients with uterine leiomyoma or carcinoma in situ.Intervention(s)A sample of ovarian endometriotic cyst tissue was obtained from each of the 32 patients during laparoscopic cystectomy. Samples of ovarian tissue and endometrium were obtained from 15 patients during or just after surgery.Main outcome measure(s)Expression of mRNA for ER-alpha and ER-beta with use of the reverse transcription-polymerase chain reaction (RT-PCR) and nonradioactive in situ hybridization (ISH) techniques.Result(s)Expression of mRNA for ER-alpha and ER-beta was observed in all of the control tissues from the normal endometrium and normal ovaries in the RT-PCR and ISH analyses, although the distribution of positive signals changed in the ISH analysis during different phases of the menstrual cycle. Messenger RNA for ER-alpha was detected in all of the ovarian endometriotic cysts analyzed (19 of 19), but mRNA for the ER-beta was limited (12 of 19) in the RT-PCR analysis. The ISH analysis confirmed the RT-PCR results and revealed that the two estrogen receptors were localized in both epithelial and stromal cells of endometriotic tissues.Conclusion(s)The results suggest that predominant expression of ER-alpha in both glandular epithelial and stromal cells may be essential to the development and growth of ovarian endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Receptors, Estrogen RNA, Messenger Adult Carcinoma in Situ Carcinoma in Situ Cysts Cysts Endometriosis Endometrium Endometrium Estrogen Receptor alpha Estrogen Receptor beta Female Humans Leiomyoma Leiomyoma Menstrual Cycle Menstrual Cycle

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (21)

Source provenance

europepmc
last seen: 2026-08-01T06:07:04.264727+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:36.046895+00:00
License: CC0 · commercial use OK