Endometriosis: Oestrogen and progesterone receptors in endometriosis: heterogeneity of different sites
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This study immunohistochemically analyzed estrogen and progesterone receptor expression in endometriosis and endometrium, finding significant heterogeneity in receptor levels within endometriosis lesions from different sites and compared to the corresponding endometrium.
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Abstract
The expression of receptors for the ovarian steroid hormones oestrogen and progesterone was studied immunohistochemically using monoclonal antibodies in samples of endometriosis and endometrium in 22 patients. In nine patients samples of endometriosis from more than one site were studied. There was marked heterogeneity in expression of receptors in endometriosis, both when comparing lesions with the corresponding endometrium and also between samples of endometriosis collected from different sites within the same patient. It was suggested that local environmental factors related to the site, depth and degree of fibrosis of the lesions determine the amount of steroid hormone stimulation reaching the lesions and account for the observed difference between endometriosis and endometrium and between endometriosis lesions of different sites.
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Cited by (25)
- Extensive heterogeneity in the expression of steroid receptors in superficial peritoneal endometriotic lesions 2023
- Ontogeny and expression profiles of steroid hormone receptors in a mouse model of endometriosis 2019
- The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival 2015
- The elusive and controversial roles of estrogen and progesterone receptors in human endometriosis. 2014
- Sex Steroids and Endometriosis 2014
- Changes in glandular and stromal estrogen and progesterone receptor isoform expression in eutopic and ectopic endometrium following treatment with the levonorgestrel-releasing intrauterine system 2011
- Estrogen receptor-alpha gene (T/C) Pvu II polymorphism in endometriosis and uterine fibroids. 2009
- Rectovaginal septum endometriosis: an immunohistochemical analysis of 62 cases. 2009
- REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids 2008
- Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer 2007
- Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis 2005
- Reduction of apoptosis and proliferation in endometriosis 2004
- Endometriosis umbilical con estudio de receptores hormonales 2003
- Endometriosis: the pathophysiology as an estrogen-dependent disease 2002
- Theories of endometriosis 2001
- Endometrial Anomalies in Women with Endometriosis 2001
- Characterization of messenger RNA expression of estrogen receptor-α and -β in patients with ovarian endometriosis 2000
- Is endometriosis an endometrial disease? 2000
- Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis 1998
- Angiogenesis in Endometriosis 1998
- Molecular Action of GnRH Analogues on Ectopic Endometrial Cells 1998
- Expression of estrogen and progesterone receptors in endometrium and peritoneal endometriosis: an immunohistochemical and in situ hybridization study 1997
- BASIC RESEARCH IN ENDOMETRIOSIS 1997
- Stereometric evaluation of peritoneal endometriosis and endometriotic nodules of the rectovaginal septum 1996
- Immunohistochemical characterization of stromal leukocytes in ovarian endometriosis: comparison of eutopic and ectopic endometrium with normal endometrium 1996
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