Molecular Action of GnRH Analogues on Ectopic Endometrial Cells

Mario Vignali, M. Vignali, Vignali M
Gynecologic and obstetric investigation · 1998 · vol. 45(Suppl. 1) , pp. 2–5 · doi:10.1159/000052845 · PMID:9628518 · W2018259866
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This study investigated whether GnRH analogues directly modulate the growth of ectopic endometrial cells, similar to their proposed effects on cancer cells.

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Abstract

The mechanisms leading to the occurrence and progression of endometriosis are far from being completely understood. After implantation or differentiation of ectopic endometrium, further proliferation of the endometriosis implants will depend either on the endocrine status or on the local production of endocrine, immunological, growth and angiogenic factors. GnRH receptors as well as GnRH analogues binding to cell membranes have been detected on human breast, ovarian and endometrial cancer cells. Thus, along with an indirect effect due to hypoestrogenism, a direct effect of GnRH analogues on both breast, ovarian and endometrial cancer cells has been suggested as a possible mechanism of action. Likewise, we speculate whether GnRH analogues may also exert a direct modulatory effect on endometriosis cell growth.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Aromatase Aromatase Breast Neoplasms Breast Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Female Gene Expression Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (48)

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