Recurrence of endometriosis in women with bilateral adnexectomy (with or without total hysterectomy) who received hormone replacement therapy

Matorras R, Roberto Matorras, Elorriaga MA, M.A. Elorriaga, Miguel A Elorriaga, Jose I Pijoan, Pijoan JI, José Ignacio Pijoán, Olga Ramón, Ramón O, Francisco J Rodríguez-Escudero, Francisco J Rodrı́guez-Escudero, Rodríguez-Escudero FJ
Fertility and sterility · 2002 · vol. 77(2) , pp. 303–308 · doi:10.1016/s0015-0282(01)02981-8 · PMID:11821087 · W2007623696
article OA: closed CC0 ⤵ 86 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

This study investigated the rate of endometriosis recurrence in women who underwent bilateral adnexectomy, with or without hysterectomy, and subsequently received hormone replacement therapy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo estimate the risk of recurrence after administration of hormone replacement therapy (HRT) among women who have had endometriosis and who underwent bilateral salpingo-oophorectomy (BSO).DesignProspective randomized trial (115 women receiving HRT and 57 not receiving HRT). SETTING; Public university hospital.Patient(s)Women with a histologic diagnosis of endometriosis in whom BSO was performed; 91.8% had a total hysterectomy.Intervention(s)Periodical clinical examination, vaginal ultrasound, and CA-125 levels; surgical evaluation and histologic study.Main outcome measure(s)Recurrence rate, prognostic factors, and a mean follow-up time of 45 months.Result(s)There was no recurrence among women who did not receive HRT, versus a 3.5% rate (4 out of 115), or 0.9% per year, in women who received HRT. Two recurrences required abdominal surgery. There was one additional patient who required surgery, but the relationship to the endometriosis recurrence was controversial. Among women receiving HRT, the following risk factors were detected: peritoneal involvement > 3 cm (2.4% recurrence per year vs. 0.3%) and incomplete surgery (22.2% per patient vs. 1.9%).Conclusion(s)Patients with a history of endometriosis in whom total hysterectomy and bilateral salpingo-oophorectomy have been performed have a low risk of recurrence when HRT is administered. In those patients, HRT is a reasonable option. However, in cases with peritoneal involvement > 3 cm, the recurrence rate makes HRT a controversial option; if HRT is indicated, it should be monitored closely.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Hormone Replacement Therapy CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Endometriosis Female Hormone Replacement Therapy Humans Middle Aged Ovariectomy Prospective Studies Recurrence Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Cited by (50)

Source provenance

europepmc
last seen: 2026-08-20T06:14:21.026120+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:13.417725+00:00
unpaywall
last seen: 2026-08-20T06:30:07.000247+00:00
License: CC0 · commercial use OK