Obravnava endometrioze v pomenopavznem obdobju

Endometriosis management after menopause DOI: https://doi.org/10.6016/ZdravVestn.3420Keywords: endometriosis, menopause, malignant transformation, oestrogen, menopausal hormone therapyAbstract Endometriosis is a disease that can affect 2-5% of all postmenopausal women. It is a disease in which the glands and stroma of the uterus are located outside the maternity area. To date, little is known in the literature about endometriosis in menopausal women. Diagnostic concerns currently relate mainly to concerns about possible malignancy. Reports in the literature describe the recurrence of endometriosis in the postmenopausal period as well as the occurrence of endometriosis de novo. The treatment of choice for symptomatic endometriosis in menopause is the surgical removal of all visible endometriotic tissue, as the risk of recurrence and conversion to malignancy is relatively high. Postmenopausal hormone therapy (MHT) is often used to relieve postmenopausal symptoms and prevent bone loss. There are studies showing that MHZ can reactivate endometriotic foci and even promote malignant transformation of foci in women with a history of endometriosis. Considering the risks of MHZ in patients, which are not fully known, special caution should be exercised with this therapy. Downloads References 1. Guy JM, Edgar H. Edgar Haydon (1859-1942): general practitioner and radium pioneer. J Med Biogr. 2009;17(3):127-34. DOI: 10.1258/jmb.2009.009015 PMID: 19723958 2. Janssen EB, Rijkers AC, Hoppenbrouwers K, Meuleman C, D’Hooghe TM. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update. 2013;19(5):570-82. DOI: 10.1093/humupd/dmt016 PMID: 23727940 3. Dowlut-McElroy T, Strickland JL. Endometriosis in adolescents. Curr Opin Obstet Gynecol. 2017;29(5):306-9. DOI: 10.1097/GCO.0000000000000402 PMID: 28777193 4. Tan DA, Almaria MJ. Postmenopausal endometriosis: drawing a clearer clinical picture. 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