Asymptomatic Atypical Hyperplasia and Endometriosis Following Treatment with Tamoxifen: A Case Report and Review of the Literature
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This case report describes atypical hyperplasia and endometriosis discovered in a patient after tamoxifen treatment, followed by a review of similar literature.
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Abstract
BackgroundTamoxifen may cause proliferative effects in the endometrium. Patients on tamoxifen have an increased risk for endometriosis, but are not routinely screened for this.CaseA 49-year-old postmenopausal patient presented for a total laparoscopic hysterectomy and bilateral salpingo-oophorectomy several years after initiating tamoxifen for breast cancer. She had no clinical history to suggest endometriosis, but was found to have extensive pelvic endometriosis intraoperatively with polypoid hyperplasia found on the pathology of the uterine and the ovarian tissue.ConclusionThis is the first case reported of an asymptomatic patient on tamoxifen with a new diagnosis of endometriosis along with atypical hyperplasia in the ectopic tissue. The potential for pre-malignant/malignant transformation may alter the treatment course if identified following tamoxifen exposure.
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References (8)
- Benign, Borderline, and Malignant Endometrioid Neoplasia Arising in Endometriosis in Association with Tamoxifen Therapy via openalex
- Benign gynecologic conditions among participants in the Breast Cancer Prevention Trial via openalex
- Concurrent tamoxifen-related Müllerian adenofibromas in uterus and ovary. via openalex
- Ovarian Endometrioid Adenocarcinoma Arising from an Endometriotic Cyst in a Postmenopausal Woman under Tamoxifen Therapy for Breast Cancer: A Case Report via openalex
- Ovarian Endometrioid Carcinoma and Endometriosis Developing in a Postmenopausal Breast Cancer Patient during Tamoxifen Therapy: A Case Report and Review of the Literature via openalex
- W2009742179 via openalex
- W2800486883 via openalex
- W6715173073 via openalex
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- europepmc
- last seen: 2026-07-31T06:09:14.520117+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:21:47.975235+00:00
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