Benign, Borderline, and Malignant Endometrioid Neoplasia Arising in Endometriosis in Association with Tamoxifen Therapy

W. Glenn McCluggage, W G McCluggage, C Bryson, Christopher L. Bryson, H Lamki, D D Boyle
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2000 · vol. 19(3) , pp. 276–279 · doi:10.1097/00004347-200007000-00013 · PMID:10907178 · W2069886674
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This report describes an endometrioid adenocarcinoma arising in ovarian endometriosis, alongside benign and borderline endometrioid adenofibroma in the same ovary, in a patient undergoing tamoxifen therapy.

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Abstract

Tamoxifen therapy may result in a variety of endometrial proliferative lesions, including adenocarcinoma, and as recently suggested, proliferative changes within endometriosis. This report describes an endometrioid adenocarcinoma arising in ovarian endometriosis in a patient taking tamoxifen. There were also foci of benign and borderline endometrioid adenofibroma in the same ovary and a synchronous endometrioid endometrial adenocarcinoma in the uterus. The spectrum of benign, borderline, and malignant endometrioid neoplasia arising within endometriosis suggests that tamoxifen, as a result of its estrogenic effects, may cause proliferative and, in rare instances, malignant changes in endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adenocarcinoma Carcinoma, Endometrioid Endometrial Neoplasms Endometriosis Ovarian Neoplasms Tamoxifen Adenocarcinoma Adenocarcinoma Adenocarcinoma Breast Neoplasms Breast Neoplasms Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Endometrial Neoplasms Endometrial Neoplasms Endometriosis Estrogen Antagonists Estrogen Antagonists Fallopian Tubes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (30)

Source provenance

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