Ovarian Endometrioid and Clear-Cell Tumors

In: Gynecologic and Obstetric Pathology · 2025 · pp. 1199–1230 · doi:10.1007/978-981-97-4822-8_6 · W4411132289
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This chapter covers the clinicopathologic features of ovarian endometrioid and clear-cell carcinomas, focusing on their association with endometriosis and recent updates on seromucinous carcinomas.

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This chapter reviews clinicopathologic features and histogenesis of ovarian endometrioid and clear-cell tumors, focusing on the established association of a large subset with endometriosis and describing alternative origins such as adenofibromatous lesions. It also highlights new updates including recognition of seromucinous carcinomas as a subtype of endometrioid carcinoma of the ovary and findings from molecular/genetic studies that many synchronous endometrioid endometrial and ovarian cancers likely originate in the endometrium, with relevant molecular pathway considerations. A key caveat is that the chapter is a narrative synthesis of clinicopathologic and molecular literature rather than a new primary study, so conclusions depend on prior study design and reporting. This paper is centrally about endometriosis–associated ovarian endometrioid and clear-cell tumors, emphasizing their clinicopathologic spectrum and their histogenic links to endometriosis.

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Abstract

Clear cell and endometrioid tumors are subtypes of Müllerian epithelial tumors that can arise throughout the gynecological tract, mainly including the uterus as well as the ovary. These subtypes of primary ovarian tumors include benign, borderline and malignant counterparts as opposed to other Müllerian sites where these tumors usually present as malignant neoplasms (carcinomas). A strong association with endometriosis has been established with the histogenesis of these tumors in a large subset, while in other cases, adenofibromatous lesions seem to be the primary origin of these tumors. The current chapter covers the clinicopathologic features of these endometriosis-associated histotypes of ovarian carcinoma. New updates include seromucinous carcinomas that now are a subtype of endometrioid carcinomas of the ovary as well as the likelihood that many cases of synchronous carcinomas, usually of endometrioid type, have an origin in the endometrium, determined by molecular and genetic type studies. Jennifer Katzenberg was an author in the previous edition, but has not contributed to the current edition. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2025 Springer Nature Singapore Pte Ltd. About this entry Cite this entry Roma, A.A. (2025). Ovarian Endometrioid and Clear-Cell Tumors. In: Zheng, W., Fadare, O., Quick, C.M. (eds) Gynecologic and Obstetric Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-97-4822-8_6 Download citation DOI: https://doi.org/10.1007/978-981-97-4822-8_6 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-97-4821-1 Online ISBN: 978-981-97-4822-8 eBook Packages: MedicineReference Module Medicine

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