Endometriosis and risks for ovarian, endometrial and breast cancers: A nationwide cohort study

Julie Brøchner Mogensen, Mogensen JB, Kjær SK, Susanne K. Kjær, Lene Mellemkjær, Allan Jensen
Gynecologic Oncology · 2016 · vol. 143(1) , pp. 87–92 · doi:10.1016/j.ygyno.2016.07.095 · PMID:27430396 · W2493271228
article OA: closed CC0 ⤵ 82 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This nationwide cohort study investigated the association between endometriosis and the risks of developing ovarian, endometrial, and breast cancers.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveA growing body of evidence suggests that endometriosis increases the risk for ovarian cancer, but it is less well studied whether the excess risk is confined to certain histotypes. Furthermore, it is not fully resolved if endometriosis is associated with endometrial- and breast cancer. The aim was to study overall- and histotype-specific risks for these hormone-dependent cancers in women with endometriosis.MethodsIn the Danish National Patient Register, we identified 45,790 women with a clinical diagnosis of endometriosis during 1977-2012. We linked the cohort to the Danish Cancer Register and calculated standardized incidence ratios (SIRs) with corresponding 95% confidence intervals (CIs).ResultsEndometriosis was associated with increased risks for ovarian cancer (SIR 1.34; 95% CI: 1.16-1.55), due primarily to endometrioid (SIR 1.64; 95% CI: 1.09-2.37) and clear-cell types (SIR 3.64; 95% CI: 2.36-5.38). An excess risk was also observed for endometrial cancer (SIR 1.43; 95% CI: 1.13-1.79), primarily of type 1 (SIR 1.54; 95% CI: 1.20-1.96); and the risk for breast cancer was increased among women aged ≥50years at first diagnosis of endometriosis (SIR 1.27; 95% CI: 1.12-1.42).ConclusionsThe results corroborate previous findings of increased risks for endometrioid and clear-cell ovarian cancer in women with endometriosis. As the first cohort study to date, we observed a significantly increased risk for endometrial cancer in women with a diagnosis of endometriosis. The increased breast cancer risk among women with endometriosis diagnosed at ≥50years of age should be studied further.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Breast Neoplasms Endometrial Neoplasms Endometriosis Ovarian Neoplasms Adult Aged Breast Neoplasms Cohort Studies Endometrial Neoplasms Endometriosis Female Humans Middle Aged Ovarian Neoplasms Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (35)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-06T06:14:42.462031+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:54.390225+00:00
unpaywall
last seen: 2026-10-06T06:46:56.404536+00:00
License: CC0 · commercial use OK