Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study

Elnaz Hajimaqsoudi, Farzaneh Darbeheshti, Seyed Mehdi Kalantar, Atiyeh Javaheri, Seyed Hamidreza Mirabutalebi, Mohammad Hasan Sheikhha
International journal of reproductive biomedicine · 2020 · vol. 18(10) , pp. 825–836 · doi:10.18502/ijrm.v13i10.7767 · PMID:33134795 · W3094250271
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case-control study found miR-125b was overexpressed in ectopic endometrium and TP53 was underexpressed in both eutopic and ectopic endometrium from women with endometriosis compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This case-control study investigated miRNA-125b and TP53 expression in people with endometriosis, aiming to assess whether endometriosis shows “cancer-like” molecular features. The work compared expression patterns between endometriosis cases and controls using the study’s molecular assays, with the central result reported in the paper regarding how miRNA-125b and TP53 expression differed. A key limitation is that, as a case-control design, it cannot establish causal direction between altered gene/miRNA expression and disease status. This paper is centrally about endometriosis — it focuses on miRNA-125b and TP53 expression and their proposed link to cancer-like features in endometriosis.

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Abstract

Background: Endometriosis is generally considered as a benign condition; however, there is a possibility for it to become cancerous. miR-125b is upregulated in both endometriotic tissues and serum samples of women with endometriosis but its potential targets in endometriosis are still not fully understood. Objective: The role of miR-125b in the regulation of TP53 expression in endometriosis was tested with a bioinformatics approach. In addition, the expression of miR-125b and TP53 in both eutopic (Eu-p) and ectopic endometrium (Ec-p) in the endometrium tissues of women with endometriosis was compared to those in the normal endometrium tissues of controls (Normal). Materials and Methods: In this case-control study, the Eu-p and Ec-p samples were collected from 20 women who underwent laparoscopic surgery, and the normal endometrium tissues were collected from 20 controls with no evidence of endometriosis. For bioinformatics approach, a protein-protein interaction network was constructed based on co-expressed potential targets of miR-125b. Quantitative polymerase chain reaction technique was used for the measurement of miR125b and TP53 expression. Results: Our results showed that miR-125b was significantly overexpressed in Ec-p (p-value: 0.021). In addition, there was a significant TP53 under expression in both the Ec-p and Eu-p samples compared with the Normal tissues (p-value: 0.003). Conclusion: The negative correlation between miR-125b and TP53 as well as a noticeable decreased expression of TP53 in both Ec-p and Eu-p samples may be interpreted as the roles of miR-125b/TP53 axis in the pathogenesis of endometriosis. In addition, these findings and bioinformatic analyses imply a possible role of miR-125b in cancer-like features of endometriosis. Key words: Endometriosis, TP53, miR-125b, Ectopic endometrium, Eutopic endometrium.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 14 October 2020 Authors Elnaz Hajimaqsoudi | Farzaneh Darbeheshti | Seyed Mehdi Kalantar | Atiyeh Javaheri | Seyed Hamidreza Mirabutalebi | Mohammad Hasan Sheikhha The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v13i10.7767', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/7767', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://journals.ssu.ac.ir/ijrmnew/article-1-1471-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/7767', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '14 October 2020', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v13i10.7767', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Elnaz Hajimaqsoudi | Farzaneh Darbeheshti | Seyed Mehdi Kalantar | Atiyeh Javaheri | Seyed Hamidreza Mirabutalebi | Mohammad Hasan Sheikhha', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v13i10.7767 JSON XML

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