Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study

Elnaz Hajimaqsoudi, Hajimaqsoudi E, Darbeheshti F, Farzaneh Darbeheshti, Seyed Mehdi Kalantar, Kalantar SM, Atiyeh Javaheri, Seyed Hamidreza Mirabutalebi, Mirabutalebi SH, Mohammad Hasan Sheikhha, Sheikhha MH
International journal of reproductive biomedicine · 2020 · vol. 18(10) , pp. 825–836 · doi:10.18502/ijrm.v13i10.7767 · PMID:33134795 · PMC7569716 · W3094250271
article OA: gold CC0 ⤵ 8 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case-control study found miR-125b was overexpressed in ectopic endometrium and TP53 was underexpressed in both eutopic and ectopic endometrium from women with endometriosis compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This case-control study investigated miRNA-125b and TP53 expression in people with endometriosis, aiming to assess whether endometriosis shows “cancer-like” molecular features. The work compared expression patterns between endometriosis cases and controls using the study’s molecular assays, with the central result reported in the paper regarding how miRNA-125b and TP53 expression differed. A key limitation is that, as a case-control design, it cannot establish causal direction between altered gene/miRNA expression and disease status. This paper is centrally about endometriosis — it focuses on miRNA-125b and TP53 expression and their proposed link to cancer-like features in endometriosis.

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Abstract

Background: Endometriosis is generally considered as a benign condition; however, there is a possibility for it to become cancerous. miR-125b is upregulated in both endometriotic tissues and serum samples of women with endometriosis but its potential targets in endometriosis are still not fully understood. Objective: The role of miR-125b in the regulation of TP53 expression in endometriosis was tested with a bioinformatics approach. In addition, the expression of miR-125b and TP53 in both eutopic (Eu-p) and ectopic endometrium (Ec-p) in the endometrium tissues of women with endometriosis was compared to those in the normal endometrium tissues of controls (Normal). Materials and Methods: In this case-control study, the Eu-p and Ec-p samples were collected from 20 women who underwent laparoscopic surgery, and the normal endometrium tissues were collected from 20 controls with no evidence of endometriosis. For bioinformatics approach, a protein-protein interaction network was constructed based on co-expressed potential targets of miR-125b. Quantitative polymerase chain reaction technique was used for the measurement of miR125b and TP53 expression. Results: Our results showed that miR-125b was significantly overexpressed in Ec-p (p-value: 0.021). In addition, there was a significant TP53 under expression in both the Ec-p and Eu-p samples compared with the Normal tissues (p-value: 0.003). Conclusion: The negative correlation between miR-125b and TP53 as well as a noticeable decreased expression of TP53 in both Ec-p and Eu-p samples may be interpreted as the roles of miR-125b/TP53 axis in the pathogenesis of endometriosis. In addition, these findings and bioinformatic analyses imply a possible role of miR-125b in cancer-like features of endometriosis. Key words: Endometriosis, TP53, miR-125b, Ectopic endometrium, Eutopic endometrium.
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In conclusion, the negative correlation between miR-125b and TP53 as well as the noticeable decreased expression of TP53 in both eutopic and ectopic samples compared with Normal controls may be interpreted in roles of miR-125b/ TP53 axis in the pathogenesis of endometriosis. In addition, these finding and bioinformatics analyses imply a possible role of miR-125b in the connection between endometriosis and malignant transformation.

Coi Statement

The authors declare that there is no conflict of interest that could be perceived as prejudicial to the impartiality of the reported research.

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endometriosis

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