The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium

Seyed Hamidreza Mirabutalebi, Noorodin Karami, Fatemeh Montazeri, Farzaneh Fesahat, Mohammad Hasan Sheikhha, Elnaz Hajimaqsoodi, Mojgan Karimi‐Zarchi, Seyed Mehdi Kalantar
In: International Journal of Reproductive BioMedicine, Vol 16, Iss 8, Pp 501-506 (2018) · 2018 · W4289730272
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This study found decreased HOXA10 and increased miR-135a expression in eutopic endometrium and increased HOXA10 and decreased miR-135a in ectopic endometrium from endometriosis patients compared to controls.

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This prospective case-control study measured miR-135a and HOXA10 expression in eutopic and ectopic endometrial tissues from 17 women with endometriosis, with eutopic endometrium from 17 women with normal endometrium serving as controls, using q-RT PCR. The authors found that HOXA10 expression was significantly decreased in case-eutopic tissue during the luteal phase versus controls, while HOXA10 was reported as increased in case-ectopic tissue (with no statistically significant difference). miR-135a expression showed a significant increase in case-eutopic luteal tissue and a significant decrease in case-ectopic tissue compared with controls, and the paper emphasizes inverse relationships between miR-135a and HOXA10 while noting the limited sample size (17 per group). This paper is centrally about endometriosis — it evaluates miR-135a and HOXA10 expression differences between eutopic and ectopic endometrium in endometriosis patients.

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Abstract

Background: The study of microRNA expression can be effective in the diagnosing and treating different diseases. miR-135a is one of the most important micro-ribonucleic acids involved in endometriosis. Among the genes that become the target of the miR-135a and are subjected to changes in the endometrium of patients with endometriosis is HOXA10 gene which is expressed in the endometrium in response to steroid hormones. Objective: The aim of this study was to evaluate the expression of miR-135a and its relationship with the level of HOXA10 gene expression in both endometrial ectopic and eutopic tissues in patients with endometriosis compared to the control samples. Materials and Methods: In this prospective case-control study, both case-eutopic and case-ectopic tissue samples were obtained from 17 women with endometriosis and the eutopic endometrial tissue was sampled from 17 women with normal endometrium as the control group. The gene's expression of miR-135a and HOXA10 were investigated using quantitative reverse transcription PCR (q-RT PCR). Results: A significant decrease in the expression of HOXA10 gene was detected in case-eutopic during the luteal phase compared to the control samples (p=0.001), while in the case-ectopic, the expression of this gene was increased (p=0.681) compared to the control samples. In addition, the expression miR-135a in the luteal phase showed a remarkable increase in the case-eutopic endometrial tissue (p=0.026) as well as a significant decrease in the case-ectopic endometrial tissue compared to the control samples (p=0.008). Conclusion: Considering the inverse relations between the over-expression of miR-135a and the reduction of HOXA10, it seems that miR-135a may be applied as an endometrial diagnostic and therapeutic biomarker.
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International Journal of Reproductive BioMedicine (Aug 2018) The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium Abstract Background: The study of microRNA expression can be effective in the diagnosing and treating different diseases. miR-135a is one of the most important micro-ribonucleic acids involved in endometriosis. Among the genes that become the target of the miR-135a and are subjected to changes in the endometrium of patients with endometriosis is HOXA10 gene which is expressed in the endometrium in response to steroid hormones. Objective: The aim of this study was to evaluate the expression of miR-135a and its relationship with the level of HOXA10 gene expression in both endometrial ectopic and eutopic tissues in patients with endometriosis compared to the control samples. Materials and Methods: In this prospective case-control study, both case-eutopic and case-ectopic tissue samples were obtained from 17 women with endometriosis and the eutopic endometrial tissue was sampled from 17 women with normal endometrium as the control group. The gene's expression of miR-135a and HOXA10 were investigated using quantitative reverse transcription PCR (q-RT PCR). Results: A significant decrease in the expression of HOXA10 gene was detected in case-eutopic during the luteal phase compared to the control samples (p=0.001), while in the case-ectopic, the expression of this gene was increased (p=0.681) compared to the control samples. In addition, the expression miR-135a in the luteal phase showed a remarkable increase in the case-eutopic endometrial tissue (p=0.026) as well as a significant decrease in the case-ectopic endometrial tissue compared to the control samples (p=0.008). Conclusion: Considering the inverse relations between the over-expression of miR-135a and the reduction of HOXA10, it seems that miR-135a may be applied as an endometrial diagnostic and therapeutic biomarker.

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