Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis

Yasaman Samadieh, Raha Favaedi, Fariba Ramezanali, Parvaneh Afsharian, Reza Aflatoonian, Maryam Shahhoseini
Reproductive sciences (Thousand Oaks, Calif.) · 2018 · vol. 26(1) , pp. 88–96 · doi:10.1177/1933719118766255 · W2794483021
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study investigated HOXA10 gene expression and its epigenetic regulation in eutopic and ectopic endometrium of infertile women with endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study examined HOXA10 gene expression and epigenetic features in the promoter region of HOXA10 in endometrium from 36 women with endometriosis and 21 fertile controls, comparing eutopic endometrium and ectopic lesions across proliferative and secretory phases using chromatin immunoprecipitation and real-time PCR. In eutopic tissue during the secretory phase, HOXA10 expression was reduced alongside lower H3K9 acetylation, higher H3K9 methylation, and greater MeCP2 binding to the HOXA10 promoter, whereas ectopic lesions showed phase-dependent patterns: induction of HOXA10 in the secretory phase with increased H3K9ac, H3K27me3, and H3K4me3, and HOXA10 upregulation in the proliferative phase with reduced MeCP2 and increased H3K4me3. A major limitation is that the work is correlational and does not establish causal mechanisms linking these chromatin changes to HOXA10-driven pathology. This paper is centrally about endometriosis — it focuses on HOXA10 epigenetic regulation in eutopic and ectopic endometrial tissues from women with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Epigenesis, Genetic Homeodomain Proteins Infertility, Female Adult DNA Methylation Endometriosis Endometriosis Female Histones Histones Homeobox A10 Proteins Homeodomain Proteins Homeodomain Proteins Humans Infertility, Female Infertility, Female Menstrual Cycle Promoter Regions, Genetic Young Adult

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License: CC0 · commercial use OK