Network-based bioinformatics analysis of HOX genes and their related genes in endometriosis

Network-based bioinformatics analysis of HOX genes and their related genes in endometriosis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Network-based bioinformatics analysis of HOX genes and their related genes in endometriosis Fereshteh Chitsazian, Raha Favaedi, Masoumeh Golestan Jahromi, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.19857/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this older preprint version Read the latest preprint version → Show more versions Abstract Background: Dysregulation of some HOX genes are important for the development of endometriosis. Endometriosis is a complex gynecologic disorder affecting as many as 10-15% of premenopausal women. The pathogenesis of endometriosis, as the presence of endometrium-like tissue outside the uterine cavity, is largely unknown. HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, in which they are necessary for endometrial growth, differentiation, and implantation. Few investigations have been studied in this vast range of HOX genes with a network-based view. Network theory allows for a holistic understanding of the role of genes in diseases. The purpose of this study is to identify genes that cause this disease by focusing on the HOX family genes and their regulatory genes. Materials & Methods: Fifteen samples of eutopic and ectopic endometrium collected from patients in proliferation phase. PCR array was performed on sample groups for 84 HOX genes and their related genes. The statistical significance was determined by using t-test. PCA and Hierarchical clustering were carried out between different groups. The genes co-expression networks were constructed based on correlation between normalized gene expression data. Gene function was annotated based on Gene Ontology, the intervention in other diseases and expression in other tissues using the DAVID to clarify the function of important genes and the mechanism of endometriosis. Results: Among the analyzed genes, 30, 40 and 35 significantly differentially expressed genes were in eutopic, ectopic compared with normal and ectopic with eutopic samples, respectively. Twenty-eight genes had no significant alteration in none of the sample groups. Conclusion: The most significant genes and the genes in co-expression networks are effective genes in development, metabolic and neural processes. Another important point is that the some non-differently expressed genes in networks have many interactions with the significant genes, indicating that these non-significant genes also are likely contributed in endometriosis. Keywords: endometriosis, HOX, PCR-array, Co-expression network Endocrinology & Metabolism endometriosis HOX PCR-array Co-expression network Figures Figure 1 Figure 2 Figure 3 Figure 4 Background Endometriosis is known as the presence of endometrial tissues inside an abnormal anatomical location other than those of the uterus. It is a common, estrogen-dependent gynecological disorder that can lead to multiple manifestations, including dysmenorrhea, pelvic pain, pelvic mass, infertility and malignant behaviors [1-4], with prevalence rates of 10-15% in women of reproductive age [5, 6]. Symptoms of endometriosis often affect social relationships, sexuality and mental health [7]. The understanding of the pathogenesis of endometriosis is poor. The combination of retrograde menstruation of endometrial tissue fragments through the fallopian tubes into the peritoneal cavity and the immune dysfunctions are the most accepted causes of the pathogenesis of endometriosis. The live endometrial fragments in retrograde menstruation can hold in the ectopic site through adhesion, aggression and angiogenesis process and then form the ectopic lesions; therefore, the inherent biological properties of eutopic endometrium may play an important role in the pathogenesis of endometriosis[8]. Although the association between endometriosis and infertility is supported in many literature [9-11], the involved mechanisms have not been figured out. Several factors have been reported, including distortion of pelvic anatomy, hormone secretion abnormalities, alterations in peritoneal fluid and fertilization disorders. Accordingly, changes in endometrial development in patients with endometriosis may help to infertility associated with endometriosis. It is believed that patients with endometriosis have reduced the incidence of implantation. Ultrastructural defects in endometrium in women with endometriosis have been reported. Molecular markers of the endometrial receptors undergo change in patients with endometriosis; the expression patterns of the endometrium in the native endometrium of women with endometriosis are aberrant. Also, changes in biochemical or molecular markers in the tissue have been pointed out [12]. The Homeobox ( HOX ) gene family operates through a conserved homeodomain as transcriptional regulators for controlling fetal morphogenesis. In addition, the lack of proper expression of the HOX gene results in developmental anomalies. As transcription factors, the HOX genes regulate other downstream target genes leading to proper endometrial development and receptivity in implantation and function in different tissues of the fetus to provide spatial and temporal coordination for each cell [13]. Initially, HOX genes were expressed during embryonic development. However, the stable expression of the HOX genes has been observed in the reproductive system. HOX genes are essential for endometrial growth, differentiation and receptivity by mediating some functions of the sex steroids during each reproduction period. 39 HOX genes have been identified to divide into four HOX loci [14], each localized on a different chromosome and containing 9 to 11 orthologous genes. Genes in the four clusters can be categorized into 13 paralogous groups. Individual genes of the HOXA cluster are assigned a distinctive identity for each part of the paramesonephric duct, leading to the development of the fallopian tubes ( hoxa9 ), uterus ( hoxa10 ), lower part of the uterus and cervix ( hoxa11 ) and upper vagina ( hoxa13 ) [15]. HOXB has been detected to be closely related to the self-renewal of the hematopoietic stem cells and effective proliferation of hematopoietic progenitor cells [16]. Studies show a collinear activation of the HOXC genes in the limb ectoderm besides, possible implication of HOXC genes in the nail/claw/hoof transition [17]. While all four HOX gene clusters are initially activated during embryonic development, both HOXA and HOXD clusters are then reactivated during the development of appendicular skeletons, involved in the building of the limbs [18]. The identification of molecular markers of endometriosis is likely to help understanding its course and eventually, to uncover novel genes to be targeted by drugs. In the present survey, we compared gene expression using PCR-array in a collection of 15 ectopic and 15 eutopic endometrium samples with 15 normal endometrial samples, focusing on 84 genes of HOX family and their related genes. Such a PCR-based approach, in spite of relatively low throughput, has the advantage to directly examine the gene expression in a direct and robust analysis and identifiy mostly related with endometriosis. Gene Ontology (GO) was searched for the intervention of genes in other diseases and expression in other tissues using the Database for Annotation, Visualization, and Integrated Discovery (DAVID; https://david.ncifcrf.gov ) [19]. Co-expression gene network was constructed using correlation between genes expression data and visualized by Cytoscape software. In silico co-expression network construction can really provide useful information about pathogenesis of disease. Several parameters can be identified to help establish hierarchies between genes from a network or even belonging to preset remote networks. In general, the identification of new deregulated gene expression networks in endometriosis highlighted some of the interactions between the protein products of these genes and caused a significant reduction in infertility due to early detection of precursor lesions [20]. Methods Patients and Tissue Collection: This cross-sectional study was approved by the Ethics Committees of Clinical and Research Centers for Infertility, Yazd, and Royan Institute, Iran. This research was approved by the ethics committee of Royan Institute (IR.ACECR.ROYAN.REC.1396.238) and all methods were carried out in compliance with the approved guidelines. All participants, donating tissue for these studies signed an informed consent after being fully aware of all procedures. Fifteen patients with endometriosis in stages III and IV, undergoing laparoscopic surgery, participated in the current survey (age: 29±1.25, ranged from 24 to 38 years old). Ectopic endometrium samples collected from them through surgery from ectopic sites in the abdomen, and eutopic endometrium samples were obtained by pipelle. None of the patients had endometrial hyperplasia, visible endometrial hyperplasia or neoplasia and inflammatory disease. Fifteen patients, who suffered from secondary infertility, underwent diagnostic laparoscopy, considered as control group (age: 28±1.67, ranged from 22 to 36 years old). They had no evidence of endometriosis, polyps, myoma and inflammatory diseases of reproduction system with at least one child by natural pregnancy. Normal Endometrial samples were taken from these women during diagnostic laparoscopy. All women participated in the present study had normal menstruation cycle and have not received hormone therapy since 3 months before the surgery. All patients were in the follicular phase of the menstrual cycle at the time of the surgical procedure. Endometrial samples, were placed immediately in RNA protection reagent, RNAlater (Ambion, Austin, TX), frozen in liquid nitrogen and stored at −80°C. RNA extraction and cDNA synthesis: Five tissue samples in each ectopic, eutopic and normal group were pooled as three biological repeats, and all following analyses were performed on the nine sample groups. RNA extraction of collected tissues was performed by using RNeasy microarray tissue mini kit (Qiagen, Cat.No: 73304) according to the manufacturer’s instructions. RNA quality and concentration was measured by using Nanodrop 2000 spectrophotometer (Thermoscientific). Then cDNA synthesis was performed with the RT2 first strand kit (Qiagen, Cat.No: 330404). PCR-Array: PCR array was conducted for HOX family genes by using RT2 profiler PCR array human homeobox ( HOX ) genes kit (Qiagen, Cat.No: PAHS-083Z) and RT2 SYBR green ROX qPCR mastermix (Qiagen, Cat.No: 330502). There were primers for 84 tests and housekeeping genes on mentioned HOX PCR array kit according to manufacturer’s instructions. Cycling condition on step one plus real time PCR system (ABI), was included an initial denaturation at 95°C for 10 minutes followed by 40 cycles at 95°C for 15 seconds, and 60°C for 1 minute. Results were expressed as values of cycle threshold (Ct) then normalized to GAPDH as housekeeping gene (control gene). To calculate fold changes in mRNA abundance 2 -∆∆Ct method was used. Statistical analysis: The statistical significance of difference in expression levels between groups was analyzed using Student’s t-test with two tails. P-value <0.05 was considered statistically significant. PCA (Principal Component analysis) [21] was carried out using the Minitab 16 statistical software. PCA Was performed to simplify the large amount of data. PCA was applied algorithm on log2 of Differentially Expressed Genes (DEGs) and non-DEGs data to underlying cluster structures of endometrial samples. Hierarchical clustering [22] was implemented by correlation coefficient and complete linkage of in Minitab 16 statistical software [23]. The methods were performed twice, using normalized gene expression data of DEGs and non-DEGs among sample groups in three clusters. Construction of the gene co-expression network: The genes co-expression networks were constructed of the basis of the normalized gene expression data. Matlab was recruited to compute the Pearson correlation between each pair of genes , and then the significant correlation pairs (p<0.05) were imported into Cytoscape software [24] (version 3.6.1) for visualization, and the circle algorithms were used [25]. The co-expression networks were constructed of the normal tissues. Coding gene functional analysis: Gene function was annotated based on the GO, the intervention in other diseases and expression in other tissues using the DAVID; https://david.ncifcrf.gov [19] to clarify the function of DEGs and the mechanism of endometriosis. Results PCR-array with primer sets targeting HOX genes and their associated genes used to evaluate the changes in their expression between ectopic and eutopic tissues with control tissues and ectopic with eutopic tissues. The genes expression which were significantly (P<0.05) altered (DEGs) in ectopic, eutopic with normal groups and ectopic with eutopic groups are illustrated in Table I. Among the analyzed genes, there are 33.33% (28) genes in non-DEG. The expression levels of 30, 41 and 35 genes were significantly altered in eutopic and ectopic compared with normal samples and ectopic rather than eutopic samples , respectively. Twelve genes were common between the three groups and 10 of 41 DEGs were exclusively related to ectopic versus normal tissue, 5 of 35 DEGs were solely related to eutopic versus normal tissue and and 3 of 35 DEGs were only related to ectopic versus eutopic tissue. One of the interesting points is that at least in one of the analysed groups, the expression out of five of the seven studied HOXB genes, were significantly up-regulated. Three genes of the HOXA cluster were present. Only HOXA9 was significantly up-regulated in ectopic versus normal and eutopic samples. Seven genes of the HOXC cluster were studied and found that expression of five of them were significantly altered in three groups of analysis. Eight genes of the HOXD cluster were analyzed, and it was shown that expression of six of them underwent significant change in different studies (Fig. 1 and Table I). DEGs were categorized into six groups based on venn diagram (Fig. 1). There are three analysis in the investigation: Comparison of expression level of the target genes in ectopic tissue with normal tissue (CtoN), comparison of expression level of the studied genes in eutopic tissue with normal tissue (UtoN) and comparison of expression level of the studied genes in ectopic tissue with eutopic tissue (CtoU). The expression of three groups of genes have changed only in one analysis such as PAX3 expression of which changes in ectopic tissue to naormal tissue. Three groups include gene expressions of which have altered in two analysis such as HLX the expression of which has changed in eutopic and ectopic tissues to normal tissue. The last group consists of the genes expression of which has siginificant ly altered in the three analysis (Fig. 1 and Table I). For further investigation, hierarchical clustering was performed on the nine studied samples using DEGs (Fig. 3A) and non-DEGs (Fig. 3B) in the eutopic, ectopic samples and normal samples . Hierarchical clustering analysis showed a grouping according to PCA analysis based on the DEGs in ectopic, eutopic and normal samples. In the present study, three samples were properly classified into separate clusters on the basis of the DEGs . But non-DEGs could not classify the same samples together. Seven co-expression networks were pointed out based on pairwise correlation of gene expression data and visualized using Cytoscape (Fig. 4). As pointed out above, expression about 64% (54/84) of the genes significantly changed between normal, eutopic and ectopic samples. All genes in the network B1 were significant genes in diseased tissues, and significant genes of ectopic tissues are abundant in the network A1 (71%) (Table II, Fig. 4). The signaling pathways present in the KEGG and Reactome databases searched for genes in the networks (Table III, Fig. 4), have identified two pathways of "Signaling pathways regulating pluripotency of stem cells" and "Transcriptional misregulation in cancer" from the KEGG database and pathway of "activation of anterior HOX genes during the early embryogenesis" from the Reactome database. Fifteen of which were in these pathways and the MEIS1 was present in all three pathways. Functional analysis The DEGs and the genes in seven networks (Fig. 4) were mapped to the DAVID database to investigate the GO, pathways, interference with other diseases and expression in other tissues. DAVID is the most popular tool in the field of functional annotation (Tables IV, V and S1). Analysis of interference with other diseases: According to analysis of interference with other diseases of genes, many DEGs in ectopic tissues play a role in developmental diseases class, such as cleft lip and clubfoot and metabolic diseases class like bone mineral density. Many DEGs in eutopic tissues are also involved in neurological diseases class like parkinson's disease and autism in addition to developmental and metabolic diseases class. Many networks A1,2,3 and 4 and B2 genes affected developmental diseases. Most genes in the network C cause neurological diseases. (Table IV). GO annotation analysis: On the basis of the GO annotation, the most of DEGs in the eutopic and ectopic tissues, and different networks were involved in the development or morphogenesis of various systems, especially skeletal system. Only most network C genes play roles in the development of the nervous system such as dopaminergic neuron and cerebellum (Table S1). Expression in other tissues: Many DEGs in the patient tissues were also expressed in different tissues such as craniofacial, prostate_carcinoma, superiorcervical ganglion, salivarygland and BM-CD33 + myeloid. Most genes in the networks were expressed in one or two tissues. Therefore, the most genes of A1, A3, A4, B1, B2, C and D networks appeared in embryo development, BM-CD33+Myeloid, superior cervical ganglion, spinal cord and ciliary ganglion respectively (Table. V). Discussion The pathogenesis of endometriosis which was related to infertility remains unclear, but studies have shown that dysregulation HOX genes are important for the development of endometriosis [2, 26-28]. The investigation of the molecular mechanism of the disease is critically important for the diagnosis, treatment and prognosis. The expression analysis by PCR-array can provide information about the expression differences. In this study, the role of HOX genes and their associated genes in the disease was investigated. The data was screened obtained 16 upregulated and 25 downregulated DEGs of ectopic to normal samples, 7 upregulated and 23 downregulated DEGs of eutopic samples to normal samples and 21 upregulated and 14 downregulated DEGs of ectopic samples to eutopic samples from 9 samples of endometriosis patients and 9 samples of normal women (Fig. 1). The GO and related disease analysis of DEGs revealed that most of them were significantly involved in development process especially skeletal system in ectopic and eutopic tissues as well as nervous system in eutopic tissues (Tables S1 and V). Using PCA and hierarchical clustering, it was observed that these DEGs were accurately classified into three ectopic, eutopic, and normal groups. Accordingly, ectopic and normal samples were located in the same top node in the hierarchical clustering and, they are also closer together compered to eutopic sample in the PCA analysis (Figs. 2, 3). Evidence indicates the eutopic endometrium has greater ability in the formation of new blood vessels, cell metastasis and invasion, and the level of its gene expression is different compared to that of normal endometrium [8]. Therefore, abnormal alterations of gene expression of eutopic endometrium might be the source of the pathogenesis of endometriosis. Although the ectopic lesions were established from eutopic tissues, evidence indicated that the properties of each are very distinctive, that it suggests genetic regulation could be involved in the alteration of these phenotypes [29]. Therefore, despite the fact that eutopic tissue is similar in appearance to normal endometrial tissue, since eutopic cells can transform into other cells, the magnitude of gene expression changes was high in these cells. The genes such as EN1 that are in both CtoU and UtoN groups, the expression of which have significantly altered in eutopic tissue to normal and ectopic endometrium, are probably important in the initiation of the disease. Also, the genes like ARX that are in both CtoU and CtoN groups, whose expression has significantly altered in ectopic endometrium to normal and eutopic endometrium, are probably important in creating of the ectopic tissue and spreading the disease. The importance of HOXB genes in endometriosis were also pointed out [26]. In the current survey, five genes out of 7 genes of HOXB cluster were of DEGs in the eutopic, ectopic or both of them and most of them upregulated (Fig. 1). It is possibly due to their role in sensory perception of pain, hemopoiesis, hematopoietic stem cell differentiation and angiogenesis [16]. In this study, our main concern was about the pathogenesis process and relationships between the DEGs. Thus co-expression network construction with expression data of all studied genes in normal samples identified seven networks (Fig. 4). The most genes of six networks were involved in developmental and metabolic processes, but genes in the network C involved in neural processes. Of the six genes forming this network, there are three DEGs dependent on the eutopic tissues. Probably the neural processes in the eutopic endometrium mentioned above (Table S1) were associated with the network C genes. Investigation of the tissues which express the genes of each network indicate that most genes in each network are expressed in a specific tissue, showing connections between the genes of each network together (Table V). Non-DEGs that were a minority in a network and had many connections with DEGs (Fig. 4) may also play a role in the development of endometriosis, but this role has not been shown a significant change in the expression of the genes. Hence, some non-DEGs genes like SIX1 may be effective in creating ectopic tissue and BARX1 genes which are likely to be effective in creating eutopic tissues. In conclusion, our findings support the general notion, concerning the role of HOX family genes in development of endometriosis. In addition, the genes, such as VAX2, PHOX2B, LMX1B, DLX1and SIX4, have high significant alteration in gene expression of endometriosis tissue samples. Most of these genes have not previously been reported as endometriosis-related genes. In addition, since some non-DEGs have many connections to DEGs in co-expression networks, these non-DEGs also play important roles in endometriosis. Accordingly, the functional study showed that the significant genes engaged in developmental, neurological and metabolic pathways. Declarations Ethics approval and consent to participate The study protocol was approved by Ethical Committee of Royan Institute for Reproductive Biomedicine. Informed consent was obtained from all the participants for being included in the study. Consent for publication Not applicable Availability of data and material Data sharing is not applicable to this article as no datasets were generated or analysed during the current study. Competing interests The authors declared no conflict of interest. Funding Not applicable Authors' contributions F.C. statistical and bioinformatics analysis and interpretation of data, wrote the manuscript. R.F. the methodological design and performed the experiments. M.G.J. performed the experiments, collected samples. M.B. provided expertise. R.A. provided expertise. P.A. provided expertise. 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Tables Table I: DEGs and the rate of gene expression changes between normal and patient tissues Ectopic than Eutopic samples Eutopic than Normal samples Ectopic than Normal samples Gene symbol Ratio * p-value Gene symbol Ratio * p-value Gene symbol Ratio * p-value DLX1 1.36 6.08E-04 DLX1 0.6 1.76E-04 DLX1 0.81 2.85E-03 EN2 1.88 2.41E-03 EN2 0.76 1.64E-02 EN2 1.43 2.55E-02 HHEX 0.74 7.02E-03 HHEX 0.88 4.14E-02 HHEX 0.65 1.09E-03 HOXB4 1.44 8.65E-04 HOXB4 1.23 2.36E-02 HOXB4 1.76 2.05E-04 HOXD3 0.89 3.29E-02 HOXD3 0.84 1.58E-02 HOXD3 0.75 5.98E-03 LBX1 2.97 7.94E-04 LBX1 0.28 6.09E-04 LBX1 0.83 9.93E-03 LMX1B 1.36 3.31E-04 LMX1B 0.6 9.80E-05 LMX1B 0.82 2.93E-03 MKX 0.34 7.45E-04 MKX 0.84 4.07E-02 MKX 0.28 1.12E-04 PITX3 1.53 6.64E-03 PITX3 0.54 3.28E-04 PITX3 0.83 1.76E-02 SHOX 1.39 2.24E-03 SHOX 0.6 5.94E-04 SHOX 0.84 7.14E-03 VAX1 1.86 9.63E-03 VAX1 0.44 3.35E-04 VAX1 0.82 1.40E-02 VSX1 1.64 1.85E-04 VSX1 0.52 2.86E-03 VSX1 0.86 3.06E-02 CUX1 0.5 4.79E-02 CUX1 1.68 4.97E-02 MEOX1 0.74 4.69E-02 EN1 2.23 2.49E-02 EN1 0.38 3.06E-02 MIXL1 0.79 3.72E-02 HOPX 0.46 4.51E-03 HOPX 1.34 5.97E-03 NKX3-1 0.89 3.41E-02 HOXC12 2.93 1.77E-02 HOXC12 0.26 5.69E-04 PAX3 0.84 4.65E-03 HOXC13 2.77 2.93E-04 HOXC13 0.33 1.47E-02 POU5F1 1.26 1.27E-02 ISL2 3.71 1.54E-03 ISL2 0.26 1.11E-03 HOXD4 0.75 4.92E-02 MEIS1 0.66 1.76E-02 MEIS1 1.63 3.45E-02 HOXD9 0.73 1.23E-03 DMBX1 1.43 3.77E-02 HLX 0.71 2.34E-02 HLX 0.73 6.29E-03 LHX1 1.45 2.32E-02 HOXB2 1.38 3.12E-02 HOXB2 1.59 8.85E-03 OTP 1.3 2.03E-03 HOXB7 1.84 3.77E-02 HOXB7 2.11 5.04E-03 PHOX2B 0.54 8.86E-05 PHOX2B 0.63 5.86E-04 SIX4 1.62 1.89E-03 SIX4 1.43 1.91E-03 VAX2 0.72 1.77E-03 VAX2 0.72 8.99E-04 ARX 0.52 3.61E-02 DLX2 0.83 1.20E-02 ARX 0.4 1.43E-05 DLX3 1.43 9.78E-04 HOXB9 1.25 2.56E-02 DLX3 1.43 8.92E-04 DLX5 1.62 3.53E-04 LMX1A 0.66 1.38E-02 DLX5 1.51 4.10E-03 DLX6 1.86 7.44E-03 PITX2 0.78 1.05E-03 DLX6 2.65 1.62E-03 HOXA9 1.55 5.61E-03 TLX1 0.53 1.88E-02 HOXA9 1.49 7.78E-03 HOXC8 0.5 2.08E-02 HOXC8 0.44 3.90E-03 HOXC9 0.47 5.83E-04 HOXC9 0.44 1.39E-02 HOXD1 0.62 3.49E-03 HOXD1 0.6 1.25E-03 HOXD12 1.61 1.40E-02 HOXD12 1.28 3.05E-02 HOXD13 1.68 1.86E-03 HOXD13 1.31 8.12E-03 MSX1 1.63 1.05E-02 MSX1 2.34 8.20E-04 MSX2 1.95 6.90E-05 MSX2 2.56 1.49E-04 PROX1 0.61 1.13E-03 PROX1 0.6 6.79E-03 ALX4 1.32 2.10E-02 HOXB3 1.73 1.82E-02 HOXC6 0.57 8.86E-03 *The ratio of gene expression between different samples Table II. The number of significant genes in the different tissues Network Name All * Eu @ Ec $ Ec/Eu & All DEGs A1 7 2 (29.5%) 5 (71%) 0 (0%) 5(71%) A2 7 1 (14%) 2 (29%) 0 (0%) 2(29%) A3 27 13 (48 %) 17 (63%) 12 (44%) 22(81%) A4 9 4 (44%) 4 (44%) 0 (0%) 5(56%) B1 4 2 (50 %) 2 (50%) 2 (50%) 4(100%) B2 12 5 (42 %) 5 (42%) 8 (67%) 8(67%) C 6 3 (50 %) 0 (0%) 2 (33%) 3(50%) * The total number of nodes @ Number of nodes with significant changes in gene expression of the eutopic to normal tissues $ Number of nodes with significant changes in gene expression of the ectopic to normal tissues & Number of nodes with significant changes in gene expression of the eutopic to ectopic tissues Table III. Pathways with genes in the constructed networks in the study Gene Symbol HOXD4 HOXB3 DLX5 ISL1 HOXB4 HOXD1 HOXD3 HESX1 OTX1 SIX1 SIX4 HOXB2 POU5F1 MEIS1 HOXA1 Network Name A1 A2 A2 A2 A3 A3 A3 A3 A3 A3 A3 A4 B1 B2 C Pathway Name R R S S R R R S S T T R S R,S,T R R: Activation of anterior HOX genes in hindbrain development during early embryogenesis S: Signaling pathways regulating pluripotency of stem cells T: Transcriptional misregulation in cancer Table IV. Other diseases in which the DEGs and the genes in five networks interfere Category Description Count P-value DEGs in Ectopic to Normal GAD_DISEASE_CLASS DEVELOPMENTAL 25 1.14E-16 GAD_DISEASE Bone Mineral Density 15 2.32E-13 GAD_DISEASE Clubfoot 6 1.07E-08 GAD_DISEASE Cleft Lip|Cleft Palate 15 3.81E-06 GAD_DISEASE autism 6 1.68E-03 GAD_DISEASE_CLASS METABOLIC 22 3.65E-03 GAD_DISEASE Parkinson's disease 4 5.05E-03 GAD_DISEASE Sleep Apnea, Obstructive 3 8.94E-03 DEGs in Eutopic to Normal GAD_DISEASE_CLASS DEVELOPMENTAL 13 1.18E-06 GAD_DISEASE Parkinson's disease 5 8.64E-05 GAD_DISEASE Cleft Lip|Cleft Palate 5 4.01E-03 GAD_DISEASE neurodevelopmental psychiatric disorders 2 8.45E-03 GAD_DISEASE_CLASS NEUROLOGICAL 11 1.33E-02 GAD_DISEASE Autism 4 2.16E-02 GAD_DISEASE Hirschsprung's disease 2 2.85E-02 GAD_DISEASE Bone Mineral Density 4 3.11E-02 GAD_DISEASE SIDS/sudden infant death syndrome 2 4.48E-02 DEGs in Ectopic to Eutopic GAD_DISEASE Bone Mineral Density 12 4.88E-11 GAD_DISEASE_CLASS DEVELOPMENTAL 17 2.87E-10 GAD_DISEASE Clubfoot 4 2.42E-05 GAD_DISEASE Cleft Lip|Cleft Palate 10 4.33E-04 GAD_DISEASE Parkinson's disease 5 1.23E-04 GAD_DISEASE autism 6 4.24E-04 GAD_DISEASE_CLASS METABOLIC 19 6.55E-04 GAD_DISEASE talipes equinovarus 2 7.38E-03 GAD_DISEASE hair thickness 2 2.38E-02 GAD_DISEASE_CLASS NEUROLOGICAL 11 2.62E-02 Genes in Network A1 GAD_DISEASE Bone Mineral Density 5 1.42E-05 GAD_DISEASE Clubfoot 2 1.43E-02 GAD_DISEASE_CLASS DEVELOPMENTAL 4 2.37E-02 GAD_DISEASE_CLASS METABOLIC 6 4.36E-02 Genes in Network A2 GAD_DISEASE_CLASS DEVELOPMENTAL 3 0.037103 Genes in Network A3 GAD_DISEASE_CLASS DEVELOPMENTAL 14 3.13E-09 GAD_DISEASE Bone Mineral Density 6 1.90E-04 GAD_DISEASE Sleep Apnea, Obstructive 3 2.87E-03 GAD_DISEASE Cleft Lip|Cleft Palate 11 2.29E-02 GAD_DISEASE Parkinson's disease 6 2.44E-02 GAD_DISEASE Clubfoot 2 4.22E-02 Genes in Network A4 GAD_DISEASE_CLASS DEVELOPMENTAL 6 3.60E-04 GAD_DISEASE Clubfoot 2 1.70E-02 Genes in Network B1 GAD_DISEASE Bone Mineral Density 2 9.21E-02 Genes in Network B2 GAD_DISEASE_CLASS DEVELOPMENTAL 5 8.53E-03 GAD_DISEASE Cleft Lip|Cleft Palate 3 2.29E-02 Genes in Network C GAD_DISEASE Neurodevelopmental psychiatric disorders 2 1.16E-03 GAD_DISEASE_CLASS NEUROLOGICAL 4 1.11E-02 GAD_DISEASE Parkinson's disease 2 3.25E-02 Table V. Other tissues in which the DEGs and the genes in five networks are expressed Category Description Count P-value DEGs in Ectopic to Normal U133A Cerebellum 30 2.23E-03 U133A Lymphomaburkittsraji 29 5.79E-03 U133A Salivarygland 30 7.70E-03 U133A Embryo_development 23 1.37E-02 U133A Amygdala 13 1.66E-02 U133A Brain 19 1.75E-02 UP_TISSUE Craniofacial 2 2.13E-02 U133A BM-CD33+Myeloid 27 2.51E-02 U133A Superiorcervical ganglion 23 2.51E-02 U133A Uterus 15 2.73E-02 U133A Prostate 26 2.85E-02 UP_TISSUE Osteoblast 2 3.09E-02 DEGs in Ectopic to Eutopic UP_TISSUE Craniofacial 2 1.33E-02 U133A Lung 12 2.87E-02 U133A BM-CD33+Myeloid 17 3.04E-02 SAGE Prostate_carcinoma 5 4.25E-02 DEGs in Eutopic to Normal UP_TISSUE Craniofacial 3 1.07E-04 U133A Superiorcervical ganglion 16 5.73E-02 U133A Salivarygland 20 7.07E-02 U133A Whole blood 11 8.47E-02 Genes in Network A1 UNIGENE_EST Embryo_development 8 3.40E-3 U133A Testis seminiferous tubule 5 1.5E-2 Genes in Network A3 UP_TISSUE Craniofacial 2 1.33E-02 U133A Lung 12 2.87E-02 U133A BM-CD33+Myeloid 17 3.04E-02 SAGE Prostate_carcinoma 5 4.25E-02 Genes in Network A4 UNIGENE_EST Uterus 6 1.30E-2 U133A Superior cervical ganglion 7 2.00E-2 Genes in Network B1 U133A Spinalcord 3 2.20E-2 Genes in Network B2 U133A Ciliary ganglion 7 9.40E-03 U133A Whole blood 7 3.00E-02 Supplementary Files SupplementaryData.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this older preprint version Read the latest preprint version → Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-10469","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":273154,"identity":"3d3957c0-3731-4bf1-89bb-0dd85d6d5c84","order_by":1,"name":"Fereshteh Chitsazian","email":"","orcid":"","institution":"Royan Institute for Reproductive Biomedicine","correspondingAuthor":false,"prefix":"","firstName":"Fereshteh","middleName":"","lastName":"Chitsazian","suffix":""},{"id":273155,"identity":"d8c91483-6559-401f-9789-65408e6a4613","order_by":2,"name":"Raha Favaedi","email":"","orcid":"","institution":"Royan Institute for Reproductive Biomedicine","correspondingAuthor":false,"prefix":"","firstName":"Raha","middleName":"","lastName":"Favaedi","suffix":""},{"id":273156,"identity":"09790eb9-815a-4c94-a74c-dc7319b7c1b2","order_by":3,"name":"Masoumeh Golestan Jahromi","email":"","orcid":"","institution":"Shahid Sadoughi University of Medical Sciences and Health Services Yazd Research and Clinical Centre for Infertility","correspondingAuthor":false,"prefix":"","firstName":"Masoumeh","middleName":"Golestan","lastName":"Jahromi","suffix":""},{"id":273157,"identity":"aa213be9-c2f7-4cc6-a5bc-6ce6e213b74c","order_by":4,"name":"Masood Bazrgar","email":"","orcid":"","institution":"Royan Institute for Reproductive Biomedicine","correspondingAuthor":false,"prefix":"","firstName":"Masood","middleName":"","lastName":"Bazrgar","suffix":""},{"id":273158,"identity":"fd4eaaf1-6a11-408f-92ca-76204a3fd4da","order_by":5,"name":"Reza Aflatoonian","email":"","orcid":"","institution":"Royan Institute for Reproductive Biomedicine","correspondingAuthor":false,"prefix":"","firstName":"Reza","middleName":"","lastName":"Aflatoonian","suffix":""},{"id":273159,"identity":"42c949b4-e207-4c15-a731-d70c7bba1e1a","order_by":6,"name":"Parvaneh Afsharian","email":"","orcid":"","institution":"Royan Institute for Reproductive Biomedicine","correspondingAuthor":false,"prefix":"","firstName":"Parvaneh","middleName":"","lastName":"Afsharian","suffix":""},{"id":273160,"identity":"ad4a2d08-bfe0-4d33-99b4-d3bc76b654f1","order_by":7,"name":"Abbas Aflatoonian","email":"","orcid":"","institution":"Shahid Sadoughi University of Medical Sciences and Health Services Yazd Research and Clinical Centre for Infertility","correspondingAuthor":false,"prefix":"","firstName":"Abbas","middleName":"","lastName":"Aflatoonian","suffix":""},{"id":273161,"identity":"63f761ec-37f2-4dc2-974c-83a70e9e2412","order_by":8,"name":"Maryam Shahhoseini","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABBElEQVRIiWNgGAWjYDACCQY2ZhDNxsDY+ECCxwbIZGw8QKyWZgMLmTSQlgbitIB0SVTYHAaz8GqRn9387HFBRZ0cn3Rzg8SNnPN2a9sPA22psYnGpcXgzjFz4xlnDhuzyRxsMJxx5nbytjOJQC3H0nIbcGmRSDCT5m07kNgmkdiQLNlzO9nsAFALY8NhnFrkZ6R/A2qpqwdpOfz337lks/MP8WthuJEDsoU5gU0isbFBgueAndkNArYY3Mgpk+Y5c9gQaEszgwRPcoLZDaAtCXj8AnTYNmmeijp5IOP5DwkeO3uz8+kPH3yoscHtMHSQCFaZQKxyELAnRfEoGAWjYBSMDAAAZSpghqnXEPAAAAAASUVORK5CYII=","orcid":"","institution":"Royan Institute","correspondingAuthor":true,"prefix":"","firstName":"Maryam","middleName":"","lastName":"Shahhoseini","suffix":""}],"badges":[],"createdAt":"2019-12-28 13:24:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.19857/v1","doiUrl":"https://doi.org/10.21203/rs.2.19857/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":315292,"identity":"0c181bd8-8f4b-412a-9cbc-ca41e3835d3d","added_by":"auto","created_at":"2020-01-01 21:43:35","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":170791,"visible":true,"origin":"","legend":"Venn diagram presentation of DEGs (P-value \u003c0.05) in ectopic samples compared to normal samples (black elipse), eutopic samples in comparison to normal samples (green elipse) and ectopic samples compared to eutopic samples (red elipse). Genes that were significantly up-regulated are enclosed in a black, green and red rectangles according to the above mentioned agreements in the same legend. In multi-colored rectangles, each color represents the up-regulation in relevant analysis in the corresponding agreement.","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/7feb573a-57cc-48a9-b161-cbbc76e50987/v1/1.png"},{"id":315293,"identity":"137b7aae-01ba-4834-afdd-a1adab6bd6e5","added_by":"auto","created_at":"2020-01-01 21:43:35","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":25990,"visible":true,"origin":"","legend":"PCA analysis of gene expression in nine sample groups. Triangle, circle and square represents normal endometrial tissues of unaffected women, ectopic endometrial tissues of patients and eutopic endometrial tissues of patients, respectively. A: PCA of DEGs. B: PCA of non-DEGs.\nPCA analysis was performed using the normalized expression data of the DEGs and non-DEGs for all the analyzed endometrial samples. PCA analysis of the DEGs (Fig. 2a) revealed three distinct clusters of eutopic, ectopic and normal samples and the PCA analysis of the non-DEGs (Fig. 2b) didn’t separate precisely these three groups. PCA graph represents the different endometrial samples to be separated according to the degree of correlation between the DEGs and non-DEGs.","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/7feb573a-57cc-48a9-b161-cbbc76e50987/v1/2.png"},{"id":315294,"identity":"3babc678-6232-4309-a4b6-f7cfbda1343f","added_by":"auto","created_at":"2020-01-01 21:43:35","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":152107,"visible":true,"origin":"","legend":"Hierarchical cluster analysis of nine samples into three clusters. A) based on DEGs; B) based on non-DEGs.","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/7feb573a-57cc-48a9-b161-cbbc76e50987/v1/3.png"},{"id":315295,"identity":"0549f17a-c3b0-4495-b597-d8f159dfd2ae","added_by":"auto","created_at":"2020-01-01 21:43:35","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":149263,"visible":true,"origin":"","legend":"Co-expression gene network. The rectangle borderlines are colored based on the significant changes of gene expression of the different groups according to Figure 1. Thick lines represent up-regulation and thin lines show down-regulation.","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/7feb573a-57cc-48a9-b161-cbbc76e50987/v1/4.png"},{"id":13484451,"identity":"8ea38971-f1c0-4764-a489-ac4f6f6d1a7b","added_by":"auto","created_at":"2021-09-16 21:57:50","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1157026,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-10469/v1/c35b94f3-1567-4c16-8b74-c7aae4e4f607.pdf"},{"id":315291,"identity":"f6a59584-90ce-45ad-936d-ee12b9a5cc64","added_by":"auto","created_at":"2020-01-01 21:43:35","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":109616,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryData.docx","url":"https://assets-eu.researchsquare.com/files/7feb573a-57cc-48a9-b161-cbbc76e50987/v1/Supplementary Data.docx"}],"financialInterests":"","formattedTitle":"Network-based bioinformatics analysis of HOX genes and their related genes in endometriosis","fulltext":[{"header":"Background","content":"\u003cp\u003eEndometriosis is known as the presence of endometrial tissues inside an abnormal anatomical location other than those of the uterus. It is a common, estrogen-dependent gynecological disorder that can lead to multiple manifestations, including dysmenorrhea, pelvic pain, pelvic mass, infertility and malignant behaviors [1-4], with prevalence rates of 10-15% in women of reproductive age [5, 6]. Symptoms of endometriosis often affect social relationships, sexuality and mental health [7]. The understanding of the pathogenesis of endometriosis is poor. The combination of retrograde menstruation of endometrial tissue fragments through the fallopian tubes into the peritoneal cavity and the immune dysfunctions are the most accepted causes of the pathogenesis of endometriosis. The live endometrial fragments in retrograde menstruation can hold in the ectopic site through adhesion, aggression and angiogenesis process and then form the ectopic lesions; therefore, the inherent biological properties of eutopic endometrium may play an important role in the pathogenesis of endometriosis[8].\u003c/p\u003e\n\u003cp\u003eAlthough the association between endometriosis and infertility is supported in many literature [9-11], the involved mechanisms have not been figured out. Several factors have been reported, including distortion of pelvic anatomy, hormone secretion abnormalities, alterations in peritoneal fluid and fertilization disorders. Accordingly, changes in endometrial development in patients with endometriosis may help to infertility associated with endometriosis. It is believed that patients with endometriosis have reduced the incidence of implantation. Ultrastructural defects in endometrium in women with endometriosis have been reported. Molecular markers of the endometrial receptors undergo change in patients with endometriosis; the expression patterns of the endometrium in the native endometrium of women with endometriosis are aberrant. Also, changes in biochemical or molecular markers in the tissue have been pointed out [12].\u003c/p\u003e\n\u003cp\u003eThe Homeobox (\u003cem\u003eHOX\u003c/em\u003e) gene family operates through a conserved homeodomain as transcriptional regulators for controlling fetal morphogenesis. In addition, the lack of proper expression of the \u003cem\u003eHOX\u003c/em\u003e gene results in developmental anomalies. As transcription factors, the \u003cem\u003eHOX\u003c/em\u003e genes regulate other downstream target genes leading to proper endometrial development and receptivity in implantation and function in different tissues of the fetus to provide spatial and temporal coordination for each cell [13]. Initially, \u003cem\u003eHOX\u003c/em\u003e genes were expressed during embryonic development. However, the stable expression of the \u003cem\u003eHOX\u003c/em\u003e genes has been observed in the reproductive system. \u003cem\u003eHOX\u003c/em\u003e genes are essential for endometrial growth, differentiation and receptivity by mediating some functions of the sex steroids during each reproduction period. 39 \u003cem\u003eHOX\u003c/em\u003e genes have been identified to divide into four \u003cem\u003eHOX\u003c/em\u003e loci [14], each localized on a different chromosome and containing 9 to 11 orthologous genes. Genes in the four clusters can be categorized into 13 paralogous groups. Individual genes of the \u003cem\u003eHOXA\u003c/em\u003e cluster are assigned a distinctive identity for each part of the paramesonephric duct, leading to the development of the fallopian tubes (\u003cem\u003ehoxa9\u003c/em\u003e), uterus (\u003cem\u003ehoxa10\u003c/em\u003e), lower part of the uterus and cervix (\u003cem\u003ehoxa11\u003c/em\u003e) and upper vagina (\u003cem\u003ehoxa13\u003c/em\u003e) [15]. \u003cem\u003eHOXB\u003c/em\u003e has been detected to be closely related to the self-renewal of the hematopoietic stem cells and effective proliferation of hematopoietic progenitor cells [16]. Studies show a collinear activation of the \u003cem\u003eHOXC\u003c/em\u003e genes in the limb ectoderm besides, possible implication of \u003cem\u003eHOXC\u003c/em\u003e genes in the nail/claw/hoof transition [17]. While all four \u003cem\u003eHOX\u003c/em\u003e gene clusters are initially activated during embryonic development, both \u003cem\u003eHOXA\u003c/em\u003e and \u003cem\u003eHOXD\u003c/em\u003e clusters are then reactivated during the development of appendicular skeletons, involved in the building of the limbs [18]. The identification of molecular markers of endometriosis is likely to help understanding its course and eventually, to uncover novel genes to be targeted by drugs.\u003c/p\u003e\n\u003cp\u003eIn the present survey, we compared gene expression using PCR-array in a collection of 15 ectopic and 15 eutopic endometrium samples with 15 normal endometrial samples, focusing on 84 genes of \u003cem\u003eHOX\u003c/em\u003e family and their related genes. Such a PCR-based approach, in spite of relatively low throughput, has the advantage to directly examine the gene expression in a direct and robust analysis and identifiy mostly related with endometriosis. Gene Ontology (GO) was searched for the intervention of genes in other diseases and expression in other tissues using the Database for Annotation, Visualization, and Integrated Discovery (DAVID; \u003cem\u003ehttps://david.ncifcrf.gov\u003c/em\u003e) [19]. Co-expression gene network was constructed using correlation between genes expression data and visualized by Cytoscape software. In silico co-expression network construction can really provide useful information about pathogenesis of disease. Several parameters can be identified to help establish hierarchies between genes from a network or even belonging to preset remote networks. In general, the identification of new deregulated gene expression networks in endometriosis highlighted some of the interactions between the protein products of these genes and caused a significant reduction in infertility due to early detection of precursor lesions [20].\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003ePatients and Tissue Collection:\u003c/strong\u003e This cross-sectional study was approved by the Ethics Committees of Clinical and Research Centers for Infertility, Yazd, and Royan Institute, Iran. This research was approved by the ethics committee of Royan Institute (IR.ACECR.ROYAN.REC.1396.238) and all methods were carried out in compliance with the approved guidelines. All participants, donating tissue for these studies signed an informed consent after being fully aware of all procedures.\u003c/p\u003e\n\u003cp\u003eFifteen patients with endometriosis in stages III and IV, undergoing laparoscopic surgery, participated in the current survey (age: 29\u0026plusmn;1.25, ranged from 24 to 38 years old). Ectopic endometrium samples collected from them through surgery from ectopic sites in the abdomen, and eutopic endometrium samples were obtained by pipelle. None of the patients had endometrial hyperplasia, visible endometrial hyperplasia or neoplasia and inflammatory disease.\u003c/p\u003e\n\u003cp\u003eFifteen patients, who suffered from secondary infertility, underwent diagnostic laparoscopy, considered as control group (age: 28\u0026plusmn;1.67, ranged from 22 to 36 years old). They had no evidence of endometriosis, polyps, myoma and inflammatory diseases of reproduction system with at least one child by natural pregnancy. Normal Endometrial samples were taken from these women during diagnostic laparoscopy.\u003c/p\u003e\n\u003cp\u003eAll women participated in the present study had normal menstruation cycle and have not received hormone therapy since 3 months before the surgery. All patients were in the follicular phase of the menstrual cycle at the time of the surgical procedure. Endometrial samples, were placed immediately in RNA protection reagent, RNAlater (Ambion, Austin, TX), frozen in liquid nitrogen and stored at \u0026minus;80\u0026deg;C.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRNA extraction and cDNA synthesis:\u003c/strong\u003e Five tissue samples in each ectopic, eutopic and normal group were pooled as three biological repeats, and all following analyses were performed on the nine sample groups.\u003c/p\u003e\n\u003cp\u003eRNA extraction of collected tissues was performed by using RNeasy microarray tissue mini kit (Qiagen, Cat.No: 73304) according to the manufacturer\u0026rsquo;s instructions. RNA quality and concentration was measured by using Nanodrop 2000 spectrophotometer (Thermoscientific). Then cDNA synthesis was performed with the RT2 first strand kit (Qiagen, Cat.No: 330404).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePCR-Array:\u003c/strong\u003e PCR array was conducted for \u003cem\u003eHOX\u003c/em\u003e family genes by using RT2 profiler PCR array human homeobox (\u003cem\u003eHOX\u003c/em\u003e) genes kit (Qiagen, Cat.No: PAHS-083Z) and RT2 SYBR green ROX qPCR mastermix (Qiagen, Cat.No: 330502). There were primers for 84 tests and housekeeping genes on mentioned HOX PCR array kit according to manufacturer\u0026rsquo;s instructions. Cycling condition on step one plus real time PCR system (ABI), was included an initial denaturation at 95\u0026deg;C for 10 minutes followed by 40 cycles at 95\u0026deg;C for 15 seconds, and 60\u0026deg;C for 1 minute. Results were expressed as values of cycle threshold (Ct) then normalized to \u003cem\u003eGAPDH\u003c/em\u003e as housekeeping gene (control gene). To calculate fold changes in mRNA abundance 2\u003csup\u003e-∆∆Ct \u003c/sup\u003emethod was used.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis: \u003c/strong\u003eThe statistical significance of difference in expression levels between groups was analyzed using Student\u0026rsquo;s t-test with two tails. P-value \u0026lt;0.05 was considered statistically significant. PCA (Principal Component analysis) [21] was carried out using the Minitab 16 statistical software. PCA Was performed to simplify the large amount of data. PCA was applied algorithm on log2 of Differentially Expressed Genes (DEGs) and non-DEGs data to underlying cluster structures of endometrial samples.\u003c/p\u003e\n\u003cp\u003eHierarchical clustering [22] was implemented by correlation coefficient and complete linkage of in Minitab 16 statistical software [23]. The methods were performed twice, using normalized gene expression data of DEGs and non-DEGs among sample groups in three clusters.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConstruction of the gene co-expression network: \u003c/strong\u003eThe genes co-expression networks were constructed of the basis of the normalized gene expression data. Matlab was recruited to compute the Pearson correlation between each pair of genes , and then the significant correlation pairs (p\u0026lt;0.05) were imported into Cytoscape software [24] (version 3.6.1) for visualization, and the circle algorithms were used [25]. The co-expression networks were constructed of the normal tissues.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoding gene functional analysis: \u003c/strong\u003eGene function was annotated based on the GO, the intervention in other diseases and expression in other tissues using the DAVID; https://david.ncifcrf.gov [19] to clarify the function of DEGs and the mechanism of endometriosis.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003ePCR-array with primer sets targeting \u003cem\u003eHOX\u003c/em\u003e genes and their associated genes used to evaluate the changes in their expression between ectopic and eutopic tissues with control tissues and ectopic with eutopic tissues. The genes expression which were significantly (P\u0026lt;0.05) altered (DEGs) in ectopic, eutopic with normal groups and ectopic with eutopic groups are illustrated in Table I. Among the analyzed genes, there are 33.33% (28) genes in non-DEG. The expression levels of 30, 41 and 35 genes were significantly altered in eutopic and ectopic compared with normal samples and ectopic rather than eutopic samples , respectively. Twelve genes were common between the three groups and 10 of 41 DEGs were exclusively related to ectopic versus normal tissue, 5 of 35 DEGs were solely related to eutopic versus normal tissue and and 3 of 35 DEGs were only related to ectopic versus eutopic tissue. One of the interesting points is that at least in one of the analysed groups, the expression out of five of the seven studied \u003cem\u003eHOXB\u003c/em\u003e genes, were significantly up-regulated. Three genes of the \u003cem\u003eHOXA\u003c/em\u003e cluster were present. Only \u003cem\u003eHOXA9\u003c/em\u003e was significantly up-regulated in ectopic versus normal and eutopic samples. Seven genes of the \u003cem\u003eHOXC\u003c/em\u003e cluster were studied and found that expression of five of them were significantly altered in three groups of analysis. Eight genes of the \u003cem\u003eHOXD\u003c/em\u003e cluster were analyzed, and it was shown that expression of six of them underwent significant change in different studies (Fig. 1 and Table I).\u003c/p\u003e\n\u003cp\u003eDEGs were categorized into six groups based on venn diagram (Fig. 1). There are three analysis in the investigation: Comparison of expression level of the target genes in ectopic tissue with normal tissue (CtoN), comparison of expression level of the studied genes in eutopic tissue with normal tissue (UtoN) and comparison of expression level of the studied genes in ectopic tissue with eutopic tissue (CtoU). The expression of three groups of genes have changed only in one analysis such as \u003cem\u003ePAX3\u003c/em\u003e expression of which changes in ectopic tissue to naormal tissue. Three groups include gene expressions of which have altered in two analysis such as \u003cem\u003eHLX \u003c/em\u003ethe expression of which has changed in eutopic and ectopic tissues to normal tissue. The last group consists of the genes expression of which has siginificant ly altered in the three analysis \u0026nbsp;(Fig. 1 and Table I).\u003c/p\u003e\n\u003cp\u003eFor further investigation, hierarchical clustering was performed on the nine studied samples using DEGs (Fig. 3A) and non-DEGs (Fig. 3B) in the eutopic, ectopic samples and normal samples\u003cstrong\u003e.\u003c/strong\u003e Hierarchical clustering analysis showed a grouping according to PCA analysis based on the DEGs in ectopic, eutopic and normal samples. In the present study, three samples were properly \u003cem\u003eclassified\u003c/em\u003e into separate clusters on the basis of the DEGs\u003cstrong\u003e. \u003c/strong\u003eBut non-DEGs could not classify the same samples together.\u003c/p\u003e\n\u003cp\u003eSeven co-expression networks were pointed out based on pairwise correlation of gene expression data and visualized using Cytoscape (Fig. 4). As pointed out above, expression about 64% (54/84) of the genes significantly changed between normal, eutopic and ectopic samples. All genes in the network B1 were significant genes in diseased tissues, and significant genes of ectopic tissues are abundant in the network A1 (71%) (Table II, Fig. 4).\u003c/p\u003e\n\u003cp\u003eThe signaling pathways present in the KEGG and Reactome databases searched for genes in the networks (Table III, Fig. 4), have identified two pathways of \"Signaling pathways regulating pluripotency of stem cells\" and \"Transcriptional misregulation in cancer\" from the KEGG database and pathway of \"activation of anterior HOX genes during the early embryogenesis\" from the Reactome database. Fifteen of which were in these pathways and the MEIS1 was present in all three pathways.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunctional analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe DEGs and the genes in seven networks (Fig. 4) were mapped to the DAVID database to investigate the GO, pathways, interference with other diseases and expression in other tissues. DAVID is the most popular tool in the field of functional annotation (Tables IV, V and S1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalysis of interference with other diseases: \u003c/strong\u003eAccording to analysis of interference with other diseases of genes, many DEGs in ectopic tissues play a role in developmental diseases class, such as cleft lip and clubfoot and metabolic diseases class like bone mineral density.\u003c/p\u003e\n\u003cp\u003eMany DEGs in eutopic tissues are also involved in neurological diseases class like parkinson's disease and autism in addition to developmental and metabolic diseases class. Many networks A1,2,3 and 4 and B2 genes affected developmental diseases. Most genes in the network C cause neurological diseases. (Table IV).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eGO annotation analysis:\u003c/strong\u003e On the basis of the GO annotation, the most of DEGs in the eutopic and ectopic tissues, and different networks were involved in the development or morphogenesis of various systems, especially skeletal system. Only most network C genes play roles in the development of the nervous system such as dopaminergic neuron and cerebellum (Table S1).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExpression in other tissues:\u003c/strong\u003e Many DEGs in the patient tissues were also expressed in different tissues such as craniofacial, prostate_carcinoma, superiorcervical ganglion, salivarygland and BM-CD33 + myeloid. Most genes in the networks were expressed in one or two tissues. Therefore, the most genes of A1, A3, A4, B1, B2, C and D networks appeared in embryo development, BM-CD33+Myeloid, superior cervical ganglion, spinal cord and ciliary ganglion respectively (Table. V).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe pathogenesis of endometriosis which was related to infertility remains unclear, but studies have shown that dysregulation \u003cem\u003eHOX\u003c/em\u003e genes are important for the development of endometriosis [2, 26-28]. The investigation of the molecular mechanism of the disease is critically important for the diagnosis, treatment and prognosis. The expression analysis by PCR-array can provide information about the expression differences. In this study, the role of \u003cem\u003eHOX\u003c/em\u003e genes and their associated genes in the disease was investigated. The data was screened obtained 16 upregulated and 25 downregulated DEGs of ectopic to normal samples, 7 upregulated and 23 downregulated DEGs of eutopic samples to normal samples and 21 upregulated and 14 downregulated DEGs of ectopic samples to eutopic samples from 9 samples of endometriosis patients and 9 samples of normal women (Fig. 1). The GO and related disease analysis of DEGs revealed that most of them were significantly involved in development process especially skeletal system in ectopic and eutopic tissues as well as nervous system in eutopic tissues (Tables S1 and V).\u003c/p\u003e\n\u003cp\u003eUsing PCA and hierarchical clustering, it was observed that these DEGs were accurately classified into three ectopic, eutopic, and normal groups. Accordingly, ectopic and normal samples were located in the same top node in the hierarchical clustering and, they are also closer together compered to eutopic sample in the PCA analysis (Figs. 2, 3). Evidence indicates the eutopic endometrium has greater ability in the formation of new blood vessels, cell metastasis and invasion, and the level of its gene expression is different compared to that of normal endometrium [8]. Therefore, abnormal alterations of gene expression of eutopic endometrium might be the source of the pathogenesis of endometriosis. Although the ectopic lesions were established from eutopic tissues, evidence indicated that the properties of each are very distinctive, that it suggests genetic regulation could be involved in the alteration of these phenotypes [29]. Therefore, despite the fact that eutopic tissue is similar in appearance to normal endometrial tissue, since eutopic cells can transform into other cells, the magnitude of gene expression changes was high in these cells. The genes such as EN1 that are in both CtoU and UtoN groups, the expression of which have significantly altered in eutopic tissue to normal and ectopic endometrium, are probably important in the initiation of the disease. Also, the genes like ARX that are in both CtoU and CtoN groups, whose expression has significantly altered in ectopic endometrium to normal and eutopic endometrium, are probably important in creating of the ectopic tissue and spreading the disease.\u003c/p\u003e\n\u003cp\u003eThe importance of \u003cem\u003eHOXB\u003c/em\u003e genes in endometriosis were also pointed out [26]. In the current survey, five genes out of 7 genes of \u003cem\u003eHOXB\u003c/em\u003e cluster were of DEGs in the eutopic, ectopic or both of them and most of them upregulated (Fig. 1). It is possibly due to their role in sensory perception of pain, hemopoiesis, hematopoietic stem cell differentiation and angiogenesis [16].\u003c/p\u003e\n\u003cp\u003eIn this study, our main concern was about the pathogenesis process and relationships between the DEGs. Thus co-expression network construction with expression data of all studied genes in normal samples identified seven networks (Fig. 4). The most genes of six networks were involved in developmental and metabolic processes, but genes in the network C involved in neural processes. Of the six genes forming this network, there are three DEGs dependent on the eutopic tissues. Probably the neural processes in the eutopic endometrium mentioned above (Table S1) were associated with the network C genes. Investigation of the tissues which express the genes of each network indicate that most genes in each network are expressed in a specific tissue, showing connections between the genes of each network together (Table V). Non-DEGs that were a minority in a network and had many connections with DEGs (Fig. 4) may also play a role in the development of endometriosis, but this role has not been shown a significant change in the expression of the genes. Hence, some non-DEGs genes like \u003cem\u003eSIX1\u003c/em\u003e may be effective in creating ectopic tissue and \u003cem\u003eBARX1\u003c/em\u003e genes which are likely to be effective in creating eutopic tissues.\u003c/p\u003e\n\u003cp\u003eIn conclusion, our findings support the general notion, concerning the role of HOX family genes in development of endometriosis. In addition, the genes, such as VAX2, PHOX2B, LMX1B, DLX1and SIX4, have high significant alteration in gene expression of endometriosis tissue samples. Most of these genes have not previously been reported as endometriosis-related genes. In addition, since some non-DEGs have many connections to DEGs in co-expression networks, these non-DEGs also play important roles in endometriosis. Accordingly, the functional study showed that the significant genes engaged in developmental, neurological and metabolic pathways.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study protocol was approved by Ethical Committee of Royan Institute for Reproductive Biomedicine. Informed consent was obtained from all the participants for being included in the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData sharing is not applicable to this article as no datasets were generated or analysed during the current study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003eThe authors declared no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eF.C. statistical and bioinformatics analysis and interpretation of data, wrote the manuscript. R.F. the methodological design and performed the experiments. M.G.J. performed the experiments, collected samples. M.B. provided expertise. R.A. provided expertise. P.A. provided expertise. A.A. provided expertise and supervision and administrative support for collecting samples. M.S. provided expertise and supervision. revision of the content of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank the participating women for donating samples for research.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eWang Y, Li Y, Yang Z, Liu K, Wang D. Genome-Wide Microarray Analysis of Long Non-Coding RNAs in Eutopic Secretory Endometrium with Endometriosis. Cell Physiol Biochem. 2015;37(6):2231-45.\u003c/li\u003e\n\u003cli\u003eSamadieh Y, Favaedi R, Ramezanali F, Afsharian P, Aflatoonian R, Shahhoseini M. Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis. Reproductive sciences. 2018:1933719118766255.\u003c/li\u003e\n\u003cli\u003eMahdian S, Aflatoonian R, Yazdi RS, Yaghmaei P, Ramazanali F, Afsharian P, et al. Macrophage migration inhibitory factor as a potential biomarker of endometriosis. Fertil Steril. 2015;103(1):153-9 e3.\u003c/li\u003e\n\u003cli\u003eSoriano D, Schonman R, Gat I, Schiff E, Seidman DS, Carp H, et al. Thoracic endometriosis syndrome is strongly associated with severe pelvic endometriosis and infertility. J Minim Invasive Gynecol. 2012;19(6):742-8.\u003c/li\u003e\n\u003cli\u003eMehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014;7(3):349-57.\u003c/li\u003e\n\u003cli\u003eSheveleva T, Bejenar V, Komlichenko E, Dedul A, Malushko A. Innovative approach in assessing the role of neurogenesis, angiogenesis, and lymphangiogenesis in the pathogenesis of external genital endometriosis. 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Epigenetic regulation of the pathological process in endometriosis. Reprod Med Biol. 2017;16(4):314-9.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003ctable style=\"margin-left: 4.65pt; border-collapse: collapse; height: 224px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 15.0pt;\"\u003e\n\u003ctd style=\"width: 759.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 15px;\" colspan=\"10\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: justify; line-height: 150%; direction: rtl; unicode-bidi: embed;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable \u003cspan style=\"color: black;\"\u003eI: DEGs and the rate of gene expression changes between normal and patient tissues\u003c/span\u003e\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.0pt;\"\u003e\n\u003ctd style=\"width: 232.625px; 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background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e2.34\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e8.20E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in; height: 8px; width: 15px;\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 11.25pt;\"\u003e\n\u003ctd style=\"width: 73.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003eMSX2\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e1.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 75.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e6.90E-05\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 74.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 80.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003eMSX2\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e2.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 11px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e1.49E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in; height: 11px; width: 15px;\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.5pt;\"\u003e\n\u003ctd style=\"width: 73.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003ePROX1\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e0.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 75.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e1.13E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 74.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 80.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003ePROX1\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e0.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e6.79E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in; height: 3px; width: 15px;\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.1pt;\"\u003e\n\u003ctd style=\"width: 73.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 75.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 74.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 80.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003eALX4\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e1.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 8px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e2.10E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in; height: 8px; width: 15px;\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.5pt;\"\u003e\n\u003ctd style=\"width: 73.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 75.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 74.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 52.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 80.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003eHOXB3\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 53.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e1.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.625px; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e1.82E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in; height: 3px; width: 15px;\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.5pt;\"\u003e\n\u003ctd style=\"width: 73.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 53.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 75.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 53.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 79.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 81.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 150%; color: black;\"\u003eHOXC6\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e0.57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 79.625px; border-top: none; border-right: none; border-left: none; border-image: initial; border-bottom: 1pt solid windowtext; background: white; padding: 0in 5.4pt; height: 3px;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; color: black; font-family: verdana, geneva;\"\u003e8.86E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in; height: 3px; width: 16px;\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e*The ratio of gene expression between different samples\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable II. The number of significant genes in the different tissues\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 426.9pt; border-collapse: collapse;\" width=\"569\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 6.7pt;\"\u003e\n\u003ctd style=\"width: 75.8pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.7pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eNetwork Name \u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.7pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAll\u003csup\u003e*\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.7pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eEu\u003csup\u003e@\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.7pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eEc\u003csup\u003e$\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.7pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eEc/Eu\u003csup\u003e\u0026amp;\u003c/sup\u003e\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 6.7pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eAll DEGs\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2 (29.5%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5 (71%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0 (0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5(71%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1 (14%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2 (29%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0 (0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2(29%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e13 (48 %)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e17 (63%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e12 (44%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e22(81%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4 (44%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4 (44%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0 (0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5(56%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eB1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2 (50 %)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2 (50%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2 (50%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4(100%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eB2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5 (42 %)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5 (42%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8 (67%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8(67%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 75.8pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"101\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"77\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 86.0pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"115\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3 (50 %)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 82.5pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"110\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0 (0%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2 (33%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 62.45pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"83\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3(50%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"color: black;\"\u003e*\u003c/span\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e The total number of nodes\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e@ Number of nodes with significant changes in gene expression of the eutopic to normal tissues\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e$\u0026nbsp; Number of nodes with significant changes in gene expression of the ectopic to normal tissues\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026amp; Number of nodes with significant changes in gene expression of the eutopic to ectopic tissues\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"font-family: verdana, geneva; font-size: 10pt;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;\" width=\"106%\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 15.0pt;\"\u003e\n\u003ctd style=\"width: 97.64%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" colspan=\"16\" width=\"97%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable III. Pathways with genes in the constructed networks in the study\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in 0in 0in 0in;\" width=\"2%\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"height: 15.0pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"page-break-inside: avoid; height: 49.0pt;\"\u003e\n\u003ctd style=\"width: 14.92%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"14%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGene Symbol\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXD4\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXB3\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDLX5\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eISL1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXB4\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.72%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXD1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.72%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXD3\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.48%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHESX1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.42%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eOTX1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.5%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eSIX1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.52%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eSIX4\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.48%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXB2\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003ePOU5F1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.0%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"7%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eMEIS1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 4.6%; border: none; padding: 0in 5.4pt 0in 5.4pt; height: 49.0pt;\" width=\"4%\"\u003e\n\u003cp style=\"line-height: 150%; margin: 0in 5.65pt .0001pt 5.65pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eHOXA1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in 0in 0in 0in;\" width=\"2%\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"height: 49.0pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.0pt;\"\u003e\n\u003ctd style=\"width: 14.92%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"14%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eNetwork Name\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.72%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.72%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.48%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.42%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.5%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.52%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.48%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eA4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eB1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.0%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"7%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eB2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 4.6%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"4%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in 0in 0in 0in;\" width=\"2%\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"height: 15.0pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.0pt;\"\u003e\n\u003ctd style=\"width: 14.92%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"14%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003ePathway Name\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.4%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.72%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.72%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.48%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.42%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.5%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.52%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eT\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.48%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 5.38%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"5%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 7.0%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"7%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR,S,T\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 4.6%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"4%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in 0in 0in 0in;\" width=\"2%\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"height: 15.0pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 25.45pt;\"\u003e\n\u003ctd style=\"width: 97.64%; padding: 0in 5.4pt 0in 5.4pt; height: 25.45pt;\" colspan=\"16\" rowspan=\"3\" width=\"97%\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eR: Activation of anterior HOX genes in hindbrain development during early embryogenesis\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eS: Signaling pathways regulating pluripotency of stem cells\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eT: Transcriptional misregulation in cancer\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; padding: 0in 0in 0in 0in;\" width=\"2%\"\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"height: 25.45pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.0pt;\"\u003e\n\u003ctd style=\"width: 2.36%; padding: 0in 5.4pt 0in 5.4pt; height: 15.0pt;\" width=\"2%\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"height: 15.0pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 4.35pt;\"\u003e\n\u003ctd style=\"width: 2.36%; padding: 0in 5.4pt 0in 5.4pt; height: 4.35pt;\" width=\"2%\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"height: 4.35pt; border: none;\" width=\"0\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-indent: -.2in; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 448.9pt; margin-left: 5.4pt; border-collapse: collapse;\" width=\"599\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable IV. Other diseases in which the DEGs and the genes in five networks interfere\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eCategory\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDescription\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eCount\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eP-value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDEGs in Ectopic to Normal\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.14E-16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBone Mineral Density\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.32E-13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eClubfoot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.07E-08\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eautism\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.68E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eMETABOLIC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e22\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.65E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eParkinson's disease\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5.05E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSleep Apnea, Obstructive\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8.94E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDEGs in Eutopic to Normal\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.18E-06\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eParkinson's disease\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8.64E-05\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCleft Lip|Cleft Palate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.01E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eneurodevelopmental psychiatric disorders\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8.45E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eNEUROLOGICAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.33E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eAutism\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.16E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eHirschsprung's disease\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.85E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBone Mineral Density\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.11E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSIDS/sudden infant death syndrome\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.48E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDEGs in Ectopic to Eutopic\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBone Mineral Density\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.88E-11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.87E-10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eClubfoot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.42E-05\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCleft Lip|Cleft Palate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.33E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eParkinson's disease\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.23E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eautism\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.24E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eMETABOLIC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6.55E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003etalipes equinovarus\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e7.38E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003ehair thickness\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.38E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eNEUROLOGICAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.62E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network A1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBone Mineral Density\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.42E-05\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eClubfoot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.43E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.37E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eMETABOLIC\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.36E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network A2\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e0.037103\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network A3\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.13E-09\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBone Mineral Density\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.90E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; 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font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.44E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eClubfoot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; 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height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.60E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eClubfoot\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.70E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network B1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBone Mineral Density\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e9.21E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network B2\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eDEVELOPMENTAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8.53E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCleft Lip|Cleft Palate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.29E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network C\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eNeurodevelopmental psychiatric disorders\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.16E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE_CLASS\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eNEUROLOGICAL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.11E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eGAD_DISEASE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eParkinson's disease\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.25E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-indent: -.5in; line-height: 150%; margin: 12.0pt 0in 10.0pt .5in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: 5.4pt; border-collapse: collapse;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"width: 5.0in; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\" width=\"480\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: justify; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable V. Other tissues in which \u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003ethe DEGs and the genes in five networks are expressed\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eCategory\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDescription\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eCount\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eP-value\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"width: 5.0in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\" width=\"480\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDEGs in Ectopic to Normal\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCerebellum\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.23E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eLymphomaburkittsraji\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e29\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5.79E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSalivarygland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e7.70E-03\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eEmbryo_development\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.37E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eAmygdala\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.66E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBrain\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.75E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUP_TISSUE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCraniofacial\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.13E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBM-CD33+Myeloid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.51E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSuperiorcervical ganglion\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.51E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUterus\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.73E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eProstate\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e26\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.85E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUP_TISSUE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eOsteoblast\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.09E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"width: 5.0in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\" width=\"480\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDEGs in Ectopic to Eutopic\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUP_TISSUE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCraniofacial\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.33E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eLung\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2.87E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eBM-CD33+Myeloid\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.04E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSAGE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eProstate_carcinoma\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e4.25E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"width: 5.0in; border: none; border-top: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\" width=\"480\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eDEGs in Eutopic to Normal\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUP_TISSUE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCraniofacial\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.07E-04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSuperiorcervical ganglion\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5.73E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eSalivarygland\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e20\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e7.07E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eWhole blood\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8.47E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"width: 5.0in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\" width=\"480\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network A1\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUNIGENE_EST\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eEmbryo_development\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e3.40E-3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eTestis seminiferous tubule\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.5E-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"width: 5.0in; border: none; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" colspan=\"4\" width=\"480\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003eGenes in Network A3\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eUP_TISSUE\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eCraniofacial\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 67.7pt; padding: 0in 5.4pt 0in 5.4pt; height: .1in;\" width=\"90\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: right; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e1.33E-02\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: .1in;\"\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003eU133A\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"padding: 0in 5.4pt 0in 5.4pt; height: .1in;\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; 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line-height: 150%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 150%; font-family: verdana, geneva;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"endometriosis, HOX, PCR-array, Co-expression network","lastPublishedDoi":"10.21203/rs.2.19857/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.19857/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background: Dysregulation of some HOX genes are important for the development of endometriosis. Endometriosis is a complex gynecologic disorder affecting as many as 10-15% of premenopausal women. The pathogenesis of endometriosis, as the presence of endometrium-like tissue outside the uterine cavity, is largely unknown. HOX genes, encoding homeodomain transcription factors, are dynamically expressed in endometrium, in which they are necessary for endometrial growth, differentiation, and implantation. Few investigations have been studied in this vast range of HOX genes with a network-based view. Network theory allows for a holistic understanding of the role of genes in diseases. The purpose of this study is to identify genes that cause this disease by focusing on the HOX family genes and their regulatory genes.\nMaterials \u0026 Methods: Fifteen samples of eutopic and ectopic endometrium collected from patients in proliferation phase. PCR array was performed on sample groups for 84 HOX genes and their related genes. The statistical significance was determined by using t-test. PCA and Hierarchical clustering were carried out between different groups. The genes co-expression networks were constructed based on correlation between normalized gene expression data. Gene function was annotated based on Gene Ontology, the intervention in other diseases and expression in other tissues using the DAVID to clarify the function of important genes and the mechanism of endometriosis.\nResults: Among the analyzed genes, 30, 40 and 35 significantly differentially expressed genes were in eutopic, ectopic compared with normal and ectopic with eutopic samples, respectively. Twenty-eight genes had no significant alteration in none of the sample groups.\nConclusion: The most significant genes and the genes in co-expression networks are effective genes in development, metabolic and neural processes. Another important point is that the some non-differently expressed genes in networks have many interactions with the significant genes, indicating that these non-significant genes also are likely contributed in endometriosis.\nKeywords: endometriosis, HOX, PCR-array, Co-expression network","manuscriptTitle":"Network-based bioinformatics analysis of HOX genes and their related genes in endometriosis","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-03-31 13:52:04","doi":"10.21203/rs.2.19857/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-01-01 21:43:34","doi":"10.21203/rs.2.19857/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"129ec8b9-58fb-47f3-bd51-b444314a49d9","owner":[],"postedDate":"January 1st, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":46082,"name":"Endocrinology \u0026 Metabolism"}],"tags":[],"updatedAt":"2020-04-14T13:55:38+00:00","versionOfRecord":[],"versionCreatedAt":"2020-01-01 21:43:34","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-10469","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-10469","version":["v1"]},"buildId":"WvIrzKhiLBfengagbw6Ux","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}