Altered expression of 3´paralogus HOX A-D clusters in endometriosis disease: A case-control study

Masoumeh Golestan Jahromi, Reza Aflatoonian, Parvaneh Afsharian, Samaneh Aghajanpour, Maryam Shahhoseini, Abbas Aflatoonian
International journal of reproductive biomedicine · 2018 · vol. 16(9) , pp. 549–556 · doi:10.29252/ijrm.16.9.549 · PMID:30643861 · W2898745628
article OA: gold CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated HOXA, HOXB, HOXC, and HOXD gene expression in endometriosis tissues and found significant differences in ectopic tissues compared to controls.

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Abstract

BACKGROUND: clusters are subdivided into 13 paralogous groups). OBJECTIVE: genes (A, B, C, and D) in ectopic and eutopic tissues of women with endometriosis compared to the normal endometrium. MATERIALS AND METHODS: genes was investigated by quantitative real-time polymerase chain reaction technique. RESULTS: in ectopic tissues versus control. CONCLUSION: ) in ectopic and eutopic tissues compare to control group. Therefore, it is possible that change of expression level of these genes in endometrium plays a role in the pathogenesis of endometriosis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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