The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

Alysson Zanatta, André Monteiro da Rocha, André M Rocha, Filomena Marino Carvalho, Filomena M Carvalho, Ricardo Pereira, Ricardo M A Pereira, Hugh S Taylor, Eduardo L A Motta, E.L.A. Motta, Edmund C Baracat, Edmund Chada Baracat, Paulo C Serafini, P. Serafini
Journal of assisted reproduction and genetics · 2010 · vol. 27(12) , pp. 701–710 · doi:10.1007/s10815-010-9471-y · PMID:20821045 · W2098949463
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

HOXA10 expression is cyclical in normal endometria but absent during the implantation window in women with endometriosis, potentially explaining infertility and appearing in ectopic foci.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper is a review of clinical and laboratory evidence on how HOXA10/Hoxa10 relates to endometriosis and associated infertility, focusing on HOX gene biology in uterine development, implantation, and reproductive tract regulation. It reports that HOXA10 is a transcription factor involved in embryogenesis and embryo implantation, showing cyclical mid-luteal/mid-implantation expression driven by estrogen and progesterone, and that women with endometriosis lack the expected mid-luteal rise. The review also describes studies finding HOXA10 expression in endometriotic foci outside the Müllerian tract, which could link HOXA10 dysregulation to implantation failure. As a narrative review, it summarizes multiple studies without providing a single new experimental dataset. This paper is centrally about endometriosis — it synthesizes evidence that altered HOXA10 expression may contribute to endometriosis-associated infertility.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Homeodomain Proteins Infertility, Female Infertility, Female Adult Embryo Implantation Endometriosis Endometrium Endometrium Estrogens Estrogens Female Gene Expression Regulation, Developmental Genes, Homeobox Homeobox A10 Proteins Homeodomain Proteins Homeodomain Proteins Humans Infertility, Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (72)

Cited by (50)

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