Fertility Preservation in Women with Endometriosis

Sabrina K. Rangi, Sabrina Rangi, Christine Hur, Elliott G. Richards, Elliott Richards, Tommaso Falcone
Journal of clinical medicine · 2023 · vol. 12(13) , pp. 4331 · doi:10.3390/jcm12134331 · PMID:37445365 · W4382401778
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Fertility preservation in women with endometriosis involves counseling on cryopreservation options and employing fertility-sparing surgical techniques to mitigate iatrogenic diminished ovarian reserve.

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Abstract

Several mechanisms have been implicated in the pathogenesis of endometriosis-related infertility. For patients considering surgery, the risk of iatrogenic injury is among the most important factors in the context of fertility preservation, along with age and individual reproductive goals. In the case of endometrioma excision, evidence overwhelmingly demonstrates the negative impact of surgery on ovarian reserve, with significant reductions in antimullerian hormone (up to 30% in unilateral versus up to 44% in bilateral endometriomas). The surgical endometriosis patient should be thoroughly counseled regarding fertility preservation and discussion should include tissue, embryo, and oocyte cryopreservation options. For the latter, data support cryopreservation of 10-15 oocytes in women ≤35 years and over 20 for those >35 years for a realistic chance to achieve one or more live births. When performing surgical interventions for endometriosis, reproductive surgeons should employ fertility-conserving surgical methods to reduce the likelihood of postoperative iatrogenic diminished ovarian reserve.

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Condition tags

endometriosisendometriomainfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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