Orthotopic transplantation of fresh ovarian cortex: a report of two cases

Donnez J, Jacques Donnez, Squifflet J, Jean Squifflet, Marie‐Madeleine Dolmans, Dolmans MM, Marie-Madeleine Dolmans, Belen Martinez-Madrid, Belén Martínez-Madrid, Pascale Jadoul, Jadoul P, Van Langendonckt A, Anne Van Langendonckt
Fertility and sterility · 2005 · vol. 84(4) , pp. 1018.e1–1018.e3 · doi:10.1016/j.fertnstert.2005.06.011 · PMID:16213862 · W2055343283
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Two cases of orthotopic ovarian cortex transplantation were performed, demonstrating successful revascularization and cryopreservation of ovarian tissue for potential future fertility restoration.

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Abstract

ObjectiveTo report two cases of orthotopic transplantation of fresh ovarian tissue.SettingAcademic hospital.Patient(s)Two patients with severe endometriosis, who underwent left oophorectomy for recurrent endometriosis.Intervention(s)Ovarian cortex was reimplanted in the heterolateral orthotopic site.Result(s)Biopsies of the grafted tissue were taken 3 months after reimplantation. Viable primordial follicles were found. The presence of a neovascular capillary network was demonstrated.Conclusion(s)Reimplantation of fresh ovarian cortex allows the survival of primordial follicles and may represent an alternative method for the preservation of ovarian cortex when oophorectomy is mandatory.

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MeSH descriptors

Ovariectomy Ovary Adult Female Humans Ovariectomy Ovary Ovary Tissue Transplantation Transplantation, Autologous

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