Fertility Preservation in Endometriosis

The number of original studies looking at fertility preservation in women with endometriosis is relatively low. Embryo cryopreservation and oocyte cryopreservation are the most common fertility preservation techniques used in patients with endometriosis. Clinical data on ovarian tissue cryopreservation in women with endometriosis are very scanty. It requires two surgical procedures: the first to harvest the ovarian tissue and the second for transplantation. Recent, more solid evidence showed that embryo and oocyte cryopreservation should be preferred to ovarian tissue cryopreservation. In addition, embryo and oocyte cryopreservation does not harm ovarian reserve and has low morbidity compared with ovarian cortex freezing. There is a lack of clinical consensus and guidelines for identifying patients with endometriosis who should be counseled to consider fertility preservation. Individualized counseling should include the patient’s age, familial history of premature ovarian insufficiency, markers of ovarian reserve, smoking, presence of endometriomas, previous surgery for endometriomas, extent, and progression of endometriosis and the need for extensive surgery involving the ovaries. Fertility preservation should be offered before surgery, especially before the excision of endometriomas which may impair the ovarian reserve. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

Benaglia L, et al. Rate of severe ovarian damage following surgery for endometriomas. Hum Reprod. 2010;25(3):678–82. Raffi F, Metwally M, Amer S. The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2012;97(9):3146–54. Somigliana E, et al. Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimullerian hormone level modifications. Fertil Steril. 2012;98(6):1531–8. Ferrero S, et al. Second surgery for recurrent unilateral endometriomas and impact on ovarian reserve: a case-control study. Fertil Steril. 2015;103(5):1236–43. Muzii L, et al. Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery. Fertil Steril. 2015;103(3):738–43. Somigliana E, et al. Surgical measures for endometriosis-related infertility: a plea for research. Placenta. 2011;32(Suppl 3):S238–42. Bourdon M, et al. Endometriosis and ART: a prior history of surgery for OMA is associated with a poor ovarian response to hyperstimulation. PLoS One. 2018;13(8):e0202399. Coccia ME, et al. Ovarian surgery for bilateral endometriomas influences age at menopause. Hum Reprod. 2011;26(11):3000–7. Busacca M, et al. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol. 2006;195(2):421–5. Di Prospero F, Micucci G. Is operative laparoscopy safe in ovarian endometriosis? Reprod Biomed Online. 2009;18(2):167. Sanchez AM, et al. The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update. 2014;20(2):217–30. Kitajima M, et al. Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis. Fertil Steril. 2011;96(3):685–91. Kitajima M, et al. Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas. Fertil Steril. 2014;101(4):1031–7. Cobo A, et al. Elective and Onco-fertility preservation: factors related to IVF outcomes. Hum Reprod. 2018;33(12):2222–31. Somigliana E, et al. Fertility preservation in women with endometriosis: for all, for some, for none? Hum Reprod. 2015;30(6):1280–6. Cobo A, et al. Vitrification: an effective new approach to oocyte banking and preserving fertility in cancer patients. Clin Transl Oncol. 2008;10(5):268–73. Elizur SE, et al. Cryopreservation of oocytes in a young woman with severe and symptomatic endometriosis: a new indication for fertility preservation. Fertil Steril. 2009;91(1):293 e1-3. Raad J, et al. Oocyte vitrification for preserving fertility in patients with endometriosis: first observational cohort study... And many unresolved questions. Letter to the editor. Eur J Obstet Gynecol Reprod Biol. 2018;220:140–1. Cobo A, et al. Oocyte vitrification for fertility preservation in women with endometriosis: an observational study. Fertil Steril. 2020;113(4):836–44. Somigliana E, Vercellini P. Fertility preservation in women with endometriosis: speculations are finally over, the time for real data is initiated. Fertil Steril. 2020;113(4):765–6. Kim SJ, et al. Oocyte cryopreservation for fertility preservation in women with ovarian endometriosis. Reprod Biomed Online. 2020;40(6):827–34. Cobo A, et al. Number needed to freeze: cumulative live birth rate after fertility preservation in women with endometriosis. Reprod Biomed Online. 2021;42(4):725–32. Santulli P, et al. Fertility preservation for patients affected by endometriosis should ideally be carried out before surgery. Reprod Biomed Online. 2021;43(5):853–63. Hong YH, et al. The significance of planned fertility preservation for women with Endometrioma before an expected ovarian cystectomy. Front Endocrinol (Lausanne). 2021;12:794117. Elizur SE, et al. Fertility preservation for women with ovarian endometriosis: results from a retrospective cohort study. Reprod Biomed Online. 2023;46(2):332–7. Fouks Y, et al. Fertility preservation in endometriosis: does patient symptomatology affect the extent of the ovarian response? Reprod Sci. 2023;30(8):2439–48. Barad DH, et al. Does hormonal contraception prior to in vitro fertilization (IVF) negatively affect oocyte yields? A pilot study. Reprod Biol Endocrinol. 2013;11:28. Meyer L, et al. Risk factors for a suboptimal response to gonadotropin-releasing hormone agonist trigger during in vitro fertilization cycles. Fertil Steril. 2015;104(3):637–42. Streuli I, et al. Shedding light on the fertility preservation debate in women with endometriosis: a swot analysis. Eur J Obstet Gynecol Reprod Biol. 2018;229:172–8. Bourdon M, et al. Does GnRH agonist triggering control painful symptom scores during assisted reproductive technology? A retrospective study. Reprod Sci. 2017;24(9):1325–33. Mathieu d'Argent E, et al. Outcomes of fertility preservation in women with endometriosis: comparison of progestin-primed ovarian stimulation versus antagonist protocols. J Ovarian Res. 2020;13(1):18. Kuroda K, et al. Combination treatment of preoperative embryo cryopreservation and endoscopic surgery (surgery-ART hybrid therapy) in infertile women with diminished ovarian reserve and uterine myomas or OVARIAN endometriomas. J Minim Invasive Gynecol. 2019;26(7):1369–75. Marklund A, et al. Endometriosis, the great imitator—a successful case of fertility preservation in a woman receiving sterilizing treatment due to a diagnosis of rectosigmoid carcinoma. Gynecol Endocrinol. 2019;35(11):945–8. Schubert B, et al. Human ovarian tissue from cortex surrounding benign cysts: a model to study ovarian tissue cryopreservation. Hum Reprod. 2005;20(7):1786–92. Carrillo L, et al. The role of fertility preservation in patients with endometriosis. J Assist Reprod Genet. 2016;33(3):317–23. Donnez J, et al. Orthotopic transplantation of fresh ovarian cortex: a report of two cases. Fertil Steril. 2005;84(4):1018. Oktay K, Oktem O. Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience. Fertil Steril. 2010;93(3):762–8. Fabbri R, et al. Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. Gynecol Endocrinol. 2018;34(7):558–62. Harzif AK, et al. Ovarian cortex freezing as a method of fertility preservation in endometriosis: a case report. Ann Med Surg (Lond). 2022;74:103222. Lantsberg D, et al. The role of fertility preservation in women with endometriosis: a systematic review. J Minim Invasive Gynecol. 2020;27(2):362–72. Horan M, Glover L, Wingfield M. Managing endometrioma to optimize future fertility. Int J Gynaecol Obstet. 2022;158(3):512–9. Sanger N, et al. Fertility preservation counselling for women with endometriosis: a European online survey. Arch Gynecol Obstet. 2023;307(1):73–85. Becker CM, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009. Carneiro MM, et al. Fertility preservation in women with endometriosis. Rev Bras Ginecol Obstet. 2021;43(10):796–802. Decanter C, et al. Endometriosis and fertility preservation: CNGOF-HAS endometriosis guidelines. Gynecol Obstet Fertil Senol. 2018;46(3):368–72. Latif S, Saridogan E, Yasmin E. FOR: fertility preservation for women with ovarian endometriosis: it is time to adopt it as routine practice. BJOG. 2022;129(11):1935–6. Roman H, et al. Direct proportional relationship between endometrioma size and ovarian parenchyma inadvertently removed during cystectomy, and its implication on the management of enlarged endometriomas. Hum Reprod. 2010;25(6):1428–32. Ferrero S, et al. Prevalence of newly diagnosed endometriosis in women attending the general practitioner. Int J Gynaecol Obstet. 2010;110(3):203–7. Benaglia L, et al. Endometrioma and oocyte retrieval-induced pelvic abscess: a clinical concern or an exceptional complication? Fertil Steril. 2008;89(5):1263–6. Maggiore LRU, et al. Endometriotic ovarian cysts do not negatively affect the rate of spontaneous ovulation. Hum Reprod. 2015;30(2):299–307. Ferrero S, et al. Fertility in patients with untreated rectosigmoid endometriosis. Reprod Biomed Online. 2021;42(4):757–67. Hirsch M, Becker C, Davies M. AGAINST: fertility preservation for women with ovarian endometriosis: it is time to adopt this as routine practice. BJOG. 2022;129(11):1937–8. Pluchino N, Roman H. Oocyte vitrification offers more space for a tailored surgical management of endometriosis. Reprod Biomed Online. 2020;41(5):753–5. Doyle JO, et al. Successful elective and medically indicated oocyte vitrification and warming for autologous in vitro fertilization, with predicted birth probabilities for fertility preservation according to number of cryopreserved oocytes and age at retrieval. Fertil Steril. 2016;105(2):459–66 e2. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Ferrero, S., Leone Roberti Maggiore, U., Gazzo, I., Racca, A. (2024). Fertility Preservation in Endometriosis. In: Ferrero, S. (eds) Endometriosis-related Infertility. Springer, Cham. https://doi.org/10.1007/978-3-031-50662-8_21 Download citation DOI: https://doi.org/10.1007/978-3-031-50662-8_21 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-50661-1 Online ISBN: 978-3-031-50662-8 eBook Packages: MedicineMedicine (R0)