Rate of severe ovarian damage following surgery for endometriomas

Laura Benaglia, Edgardo Somigliana, Valentina Vighi, G Ragni, Guido Ragni, Paolo Vercellini, Luigi Fedele
Human Reproduction · 2010 · vol. 25(3) , pp. 678–682 · doi:10.1093/humrep/dep464 · PMID:20083485 · W2156983221
article OA: bronze CC0 ⤵ 142 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that 13% of ovaries surgically treated for endometriomas showed no follicular growth upon stimulation, highlighting a significant rate of severe ovarian damage.

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Abstract

BACKGROUND: There is growing and consistent evidence showing that ovarian reserve is affected following surgical excision of ovarian endometriomas. Of particular concern is the risk of severe ovarian damage leading to unresponsiveness to ovarian hyperstimulation. In this study, we aimed to determine the rate of this complication. METHODS: Ninety-three women underwent surgery for monolateral endometriomas were recruited. Patients who underwent IVF were selected and, in all cases, follicular growth was monitored by serial transvaginal ultrasonography. The main outcome measure was the rate of ovaries remaining silent when stimulated after surgery for endometriomas. RESULTS: Absence of follicular growth was observed in 12 operated ovaries although this event never occurred in the contralateral gonad (P < 0.001). The frequency (95% confidence interval) of severe ovarian damage following surgery was 13% (7-21%). CONCLUSIONS: Severe ovarian damage, occurring in gonads operated on for ovarian endometriomas, is not a rare event.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Follicle Ovary Postoperative Complications Adult Endometriosis Female Fertilization in Vitro Humans Ovarian Follicle Ovary Ovulation Induction Primary Ovarian Insufficiency Primary Ovarian Insufficiency Treatment Outcome

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References (33)

Cited by (50)

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