Oocyte cryopreservation for fertility preservation in women with ovarian endometriosis

Se Jeong Kim, Kim SJ, Seul Ki Kim, Kim SK, Jung Ryeol Lee, Suh CS, Chang Suk Suh, Kim SH, Seok Hyun Kim
Reproductive BioMedicine Online · 2020 · vol. 40(6) , pp. 827–834 · doi:10.1016/j.rbmo.2020.01.028 · PMID:32295746 · W3004862693
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This study investigated oocyte cryopreservation as a fertility preservation method for women diagnosed with ovarian endometriosis.

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Abstract

Research-questionWhat is the clinical usefulness of oocyte cryopreservation for fertility preservation in women with ovarian endometriosis?DesignClinical characteristics were retrospectively analysed in 34 women with endometrioma before a planned ovarian cystectomy. Ovarian stimulation outcomes were compared according to laterality. A one-to-one propensity score-matched analysis was conducted to compare ovarian stimulation outcomes of the first cycle in patients with endometrioma undergoing fertility preservation with those in infertile patients without endometrioma who underwent IVF treatment. The number of oocytes cryopreserved in repeated ovarian stimulation cycles was analysed.ResultsThe mean endometrioma size at diagnosis was 6.0 ± 2.5 cm. The mean age, serum anti-Mullerian hormone levels and number of oocytes cryopreserved were 30.7 ± 5.9 years, 1.85 ± 1.14 ng/ml, and 4.8 ± 3.2, respectively. The number of oocytes cryopreserved in bilateral endometrioma compared with unilateral endometrioma patients was 4.1 ± 2.9 versus 5.7 ± 3.4 (P = 0.600). In the propensity score-matched cohort (n = 22 per group), the number of oocytes retrieved was significantly lower in the patients with endometrioma undergoing fertility preservation compared with that in infertile patients without endometrioma (5.4 ± 3.8 versus 8.1 ± 4.8; P = 0.045). A total of 13 (38.2%) patients with endometrioma underwent repeated stimulation. The median (interquartile range) number of cryopreserved oocytes at the first and the second cycle were 3.0 (2.5-6.0) and 5.0 (2.5-7.5), respectively.ConclusionsWomen with endometrioma should be counselled about oocyte cryopreservation for fertility preservation before surgery. The number of cryopreserved oocytes can be increased by repeated oocyte retrieval.

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Condition tags

endometriosis

MeSH descriptors

Cryopreservation Endometriosis Fertility Preservation Oocytes Ovarian Diseases Ovarian Reserve Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Endometriosis Endometriosis Endometriosis Female Fertility Preservation Humans Oocyte Retrieval Ovarian Diseases Ovarian Diseases Ovarian Diseases Retrospective Studies

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