Ovarian endometriosis

Busacca M, Mauro Busacca, Michele Vignali, M. Vignali
Current opinion in obstetrics & gynecology · 2003 · vol. 15(4) , pp. 321–326 · doi:10.1097/01.gco.0000084247.09900.4f · PMID:12858105 · W2326649111
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This review analyzes controversies in ovarian endometriosis, including pathogenesis, malignant transformation, and surgical therapy, highlighting recent findings on etiology, genetic alterations, and conservative laparoscopic excision.

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Abstract

PURPOSE OF REVIEW: This review analyzes the literature on ovarian endometrioma, examining the controversies on pathogenesis, malignant transformation and surgical therapy. RECENT FINDINGS: Recent literature reflects the necessity of clearly defining the ethiologic and pathologic factors that determine the origin of ovarian endometriosis and explain the increase in the condition with the prospect of developing effective prevention therapy. The possibility that ovarian endometriomas undergo malignant transformation is widely reported in the literature. Recent studies underline the importance of detecting histological differences in endometriosis (hyperplasia and atypia) and several studies of molecular biology support the theory of genetic alterations interfering with malignant transformation of ovarian endometriosis. SUMMARY: The surgical approach must take into account all this information and, when the therapy is conservative, complete excision of the disease must be laparoscopically performed without affecting the healthy ovarian tissue.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Ovarian Diseases Cell Transformation, Neoplastic Female Humans Infertility, Female Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (93)

Cited by (50)

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License: CC0 · commercial use OK