Histologic Transformation of Benign Endometriosis to Early Epithelial Ovarian Cancer

Sainz de la Cuesta R, R Sainz de la Cuesta, Ricardo Sáinz de la Cuesta, J H Eichhorn, Eichhorn JH, John H. Eichhorn, Laurel W. Rice, L W Rice, Rice LW, Fuller AF Jr, A F Fuller, Arlan F. Fuller, Nikrui N, N Nikrui, Najmosama Nikrui, Barbara A. Goff, B A Goff
Gynecologic Oncology · 1996 · vol. 60(2) , pp. 238–244 · doi:10.1006/gyno.1996.0032 · PMID:8631545 · W1993440441
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This paper describes the histological progression of benign endometriosis to early-stage epithelial ovarian cancer.

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Abstract

Between 1975 and 1990, 79 patients with Stage I epithelial ovarian cancer were treated at Massachusetts General Hospital. Patients were identified from the tumor registry and medical records were retrospectively reviewed. Pathological slides were evaluated for the presence of endometriosis, specifically looking for malignancy arising in endometriosis. Evidence of endometriosis was found in 22 of the 79 cases (28%). In the 23 cases of endometrioid histology, 9 cases (39%) were associated with endometriosis and, in the 17 cases of clear cell tumors, 7 (41%) were associated with endometriosis. All 8 cases of mixed histology had clear cell and/or endometrioid components and 4 cases (50%) were associated with endometriosis. Endometrioid adenocarcinoma accounted for 41% of the tumors associated with endometriosis, clear cell carcinoma 31%, mixed (endometrioid and/or clear cell types) 18%, and other types 9%. Among the 22 patients with associated endometriosis, we found 7 carcinomas (32%) arising in endometriosis. In these 7 cases a spectrum of benign and atypical endometriosis with a transition to clear cell or endometrioid adenocarcinoma were identified. These premalignant changes were characterized by cytologic atypia and architectural proliferation. Endometriosis was frequently encountered among patients with Stage I epithelial ovarian cancer of endometrioid and clear cell histologies. Endometriosis may play a role in the pathogenesis of some early stage malignant ovarian epithelial neoplasms.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Ovarian Diseases Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adult Aged Aged, 80 and over Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Female Humans Incidence Middle Aged Neoplasm Recurrence, Local

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (10)

Cited by (50)

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