Apoptosis induction of human endometriotic epithelial and stromal cells by noscapine.

Mohammad Rasool Khazaei, Mohammad Rasoul Khazaei, Zahra Rashidi, Farzaneh Chobsaz, Mozafar Khazaei
Iranian journal of basic medical sciences · 2016 · vol. 19(9) , pp. 940–945 · doi:10.22038/ijbms.2016.7593 · PMID:27803780 · W2526530315
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Noscapine at concentrations of 10-100 µM for 24-72 hours induced apoptosis in human endometriotic epithelial and stromal cells.

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Abstract

OBJECTIVES: . MATERIALS AND METHODS: study, endometrial biopsies from endometriosis patients (n=9) were prepared and digested by an enzymatic method (collagenase I, 2 mg/ml). Stromal and epithelial cells were separated by sequential filtration through a cell strainer and ficoll layering. The cells of each sample were divided into five groups: control (0), 10, 25, 50 and 100 micromole/liter (µM) concentration of noscapine and were cultured for three different periods of times; 24, 48 and 72 hr. Cell viability was assessed by colorimetric assay. Nitric oxide (NO) concentration was measured by Griess reagent. Cell death was analyzed by Acridine Orange (AO)-Ethidium Bromide (EB) double staining and Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay. Data were analyzed by one-way ANOVA. RESULTS: <0.05). Concentrations of NO didn't show a significant decrease. CONCLUSION: Noscapine increased endometriotic epithelial and stromal cell death and can be suggested as a treatment for endometriosis.

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endometriosis

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