Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis

Khazaei MR, Rashidi Z, Mohammad Rasool Khazaei, Zahra Rashidi, Chobsaz F, Farzaneh Chobsaz, Niromand E, Elham Niromand, Khazaei M, Mozafar Khazaei
Reproductive biology · 2020 · vol. 20(4) , pp. 484–490 · doi:10.1016/j.repbio.2020.07.012 · PMID:32896495 · W3084429271
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Resveratrol was found to inhibit the growth and angiogenesis of human endometrial tissue within an in vitro three-dimensional model of endometriosis.

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Abstract

Endometriosis is a chronic estrogen-dependent disorder and one of the most common causes of infertility in women. Resveratrol (RES) is a polyphenolic and phytoestrogenic compound with anti-oxidative, anti-inflammatory, anti-angiogenic, and anti-estrogenic properties. The aim of the present study was to investigate the effect of different concentrations of RES on human endometrial growth and angiogenesis in an in vitro three-dimensional (3D) model of endometriosis.Human endometrial tissues of endometriosis (endometriotic) and normal (endometrial) subjects (n = 9/groups) were biopsied in sterile conditions and cut into 1 × 2 mm pieces. Tissue fragments of each biopsy were given concentrations of 0 (control), 10, 50, 100 and 200 μM RES for 21 days in 3D culture condition using fibrin as an extracellular matrix. Scoring methods were used for tissue changes, including; cellular invasion, monolayer formation and angiogenesis. Nitric oxide (NO) was measured using Griess's reaction, and quantitative real-time polymerase chain reaction (qRT-PCR) was used to evaluate the apoptotic gene expression.The mean of growth scores of endometriotic and endometrial tissue showed a significant dose dependent inhibition (P < 0.05). The levels of NO also significantly decreased in different groups. Apoptotic genes (P53, Bax, Bcl2 and caspase 3) and Sirt1 showed a significant increase in various concentrations of RES in both tissues (P < 0.05).RES exert dose- and time-dependent inhibitory effects on human endometrial tissue, and its higher doses suggested it as a natural supplement to inhibit the growth and treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Resveratrol Tissue Culture Techniques Adult Apoptosis Apoptosis Apoptosis Biopsy Dose-Response Relationship, Drug Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Humans Models, Biological Neovascularization, Pathologic

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