Resveratrol and endometriosis: In vitro and animal studies and underlying mechanisms (Review)

Roya Kolahdouz Mohammadi, Roya Kolahdouz‐Mohammadi, Arablou T, Tahereh Arablou
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017 · vol. 91 , pp. 220–228 · doi:10.1016/j.biopha.2017.04.078 · PMID:28458160 · W2608846221
review OA: closed CC0 ⤵ 40 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review synthesizes in vitro and animal studies on resveratrol's effects and mechanisms related to endometriosis.

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Abstract

Endometriosis is characterized by the existence of endometrial tissue and stroma exterior to the uterus. Despite the high prevalence, the etiology of endometriosis remains elusive. The search for the most promising compounds for treatment of endometriosis has led to the identification of resveratrol. Resveratrol, a plant-derived polyphenolic phytoalexin, demonstrates broad-spectrum health beneficial effects, including anti-proliferative, anti-inflammatory, antineoplastic and antioxidant. Because of these properties and its wide distribution in plants, resveratrol is proposed as a great potential to treat endometriosis. In animal models of endometriosis, resveratrol supplementation has displayed beneficial results as it decreased the number and volume of endometrial implants, suppressed proliferation, vascularization, inflammation, cell survival and increased apoptosis. On the other hand, resveratrol treatment in-vitro studies, reduced invasiveness of endometriotic stromal cells (ESCs) and suppressed their inflammatory responses. In this review, we will summarize the recent studies in in-vitro and animal studies on resveratrol and endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Stilbenes Animals Biological Availability Endometriosis Female Humans Inflammation Inflammation Oxidative Stress Oxidative Stress Resveratrol Stilbenes Stilbenes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (97)

Cited by (40)

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License: CC0 · commercial use OK