Increased Nuclear Expression of Nuclear Factor Kappa‐B p65 Subunit in the Eutopic Endometrium and Ovarian Endometrioma of Women with Advanced Stage Endometriosis

Sung Hoon Kim, Kim SH, Hyo Jin Ihm, Ihm HJ, Young Sang Oh, Oh YS, Hee Dong Chae, Chae HD, Chung‐Hoon Kim, Chung-Hoon Kim, Kim CH, Byung Moon Kang, Kang BM
American journal of reproductive immunology (New York, N.Y. : 1989) · 2013 · vol. 70(6) , pp. 497–508 · doi:10.1111/aji.12161 · PMID:24118362 · W2082470006
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Nuclear NF-κB p65 subunit expression is elevated in the eutopic endometrium and ovarian endometrioma of women with advanced endometriosis, and proinflammatory cytokines increase its expression and DNA binding in endometrial cells.

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Abstract

PROBLEM: We evaluated whether the expression of NF-кB p65 subunit is increased in the eutopic endometrium and/or in the ovarian endometrioma of women with advanced stage endometriosis, and ascertained in vitro effects of proinflammatory cytokines on the expression and DNA binding of NF-кB p65 subunit in endometrial cells. METHOD OF STUDY: Immunohistochemistry was performed to compare the nuclear NF-кB p65 subunit immunoreactivity between women with and without advanced stage endometriosis. The nuclear NF-кB p65 subunit expression and DNA binding were also analyzed in endometrial cells treated with tumor necrosis factor-alpha (TNF-α) or interleukin-1beta (IL-1β) utilizing Western blot analysis, enzyme-linked immunosorbent assay, and electrophoretic mobility shift assay. RESULTS: The immunoreactivity of the nuclear NF-кB p65 subunit was significantly increased in the eutopic endometrium as well as in the ovarian endometrioma of women with endometriosis compared with the controls. In vitro treatment of endometrial cells with TNF-α and IL-1β led to a significant increase in nuclear NF-кB p65 subunit expression and DNA binding. CONCLUSIONS: The nuclear expression of NF-κB p65 is increased in the eutopic endometrium and ovarian endometrioma of women with advanced stage endometriosis, which strongly suggests that NF-кB signaling plays a crucial role in the pathogenesis and/or pathophysiology of endometriosis.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cell Nucleus Endometriosis Endometrium Ovarian Neoplasms Transcription Factor RelA Adult Cell Nucleus Cell Nucleus Cell Nucleus Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Interleukin-1beta Interleukin-1beta Ovarian Neoplasms

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