Surgical Removal of Endometrioma Decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) Expression in the Eutopic Endometrium During the Implantation Window

Önder Çelik, Onder Celik, Ebru Çelik, Ebru Celik, İlgın Türkçüoğlu, Ilgin Turkcuoglu, Ercan Yılmaz, Ercan Yilmaz, Mustafa Ulaş, Mustafa Ulas, Yavuz Şimşek, Yavuz Simsek, Abdullah Karaer, Nilufer Celik, Nilüfer Çelik, Nasuhi Engin Aydin, Nasuhi Engin Aydın, Ibrahim Ozerol, İbrahim Halil Özerol, Cihat Ünlü, Cihat Unlu
Reproductive sciences (Thousand Oaks, Calif.) · 2012 · vol. 20(7) , pp. 762–770 · doi:10.1177/1933719112466307 · PMID:23221171 · W2157489825
article OA: closed CC0 ⤵ 19 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Surgical removal of endometrioma decreased NF-kB1 and NF-kB p65 expression in the eutopic endometrium of infertile women.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study examined whether laparoscopic removal of an ovarian endometrioma changes nuclear factor-kappa B signaling in the eutopic endometrium during the implantation window in infertile women. The authors compared endometrial samples collected in the mid-secretory phase before surgery and again 3 months after laparoscopic cystectomy in 15 infertile patients with endometrioma, using 10 infertile women with nonendometriotic ovarian cysts and 10 healthy fertile women as controls; NF-kB1 (p50/105) was measured by ELISA and NF-kB p65 (Rel A) by immunoreactivity. NF-kB1 levels were higher in eutopic endometrium of infertile women with endometrioma than in both control groups, and surgical removal significantly decreased NF-kB1 and reduced NF-kB p65 immunoreactivity. The paper’s main limitation is its small sample size (especially for subgroup comparisons) and the lack of mechanistic demonstration beyond expression changes. This paper is centrally about endometriosis — it tests how laparoscopic endometrioma removal alters NF-κB1 and NF-κB p65 expression in eutopic endometrium during the implantation window.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Embryo Implantation Endometriosis Endometriosis Endometrium NF-kappa B p50 Subunit Transcription Factor RelA Adult Embryo Implantation Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Regulation Humans Infertility, Female Infertility, Female Infertility, Female Infertility, Female NF-kappa B p50 Subunit

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