{"paper_id":"84b3df18-7b45-4ff4-b043-47c2054829e1","body_text":"Abstract\nWe aimed to investigate whether the surgical removal of endometrioma alters the nuclear factor-kappa B1 (NF-kB1; p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium of infertile women with endometrioma before and after laparoscopic removal of the ovarian endometrioma during the mid-secretory phase. Infertile women with endometrioma (n = 15) were enrolled. Infertile patients with nonendometriotic ovarian cyst (n = 10) and healthy fertile women (n = 10) were recruited as controls. Endometrial samples were obtained before and 3 months after the laparoscopic cystectomy. The NF-kB1 (p50/105) levels were analyzed by enzyme-linked immunosorbent assay (ELISA) in the endometrium of all groups before and after laparoscopic ovarian cystectomy during implantation window. Expression of NF-kB1 (p50/105) in eutopic endometrium was significantly higher in infertile women with endometrioma compared to nonendometriotic cyst and fertile controls (P < .05). Laparoscopic cystectomy resulted in a significant decrease in NF-kB1 expression in women with endometrioma. The NF-kB p65 (Rel A) immunoreactivity of eutopic endometrium decreased significantly subsequent to the surgical removal of the endometrioma. In conclusion, increased endometrial NF-kB expression may contribute to endometriosis-associated infertility.\nSimilar content being viewed by others\nReferences\nHouston DE. Evidence for the risk of pelvic endometriosis by age, race and socioeconomic status. Epidemiol Rev. 1984;6:167–191.\nCramer DW. Epidemiology of endometriosis in adolescents. In: Wilson EA, ed. Endometriosis. New York, NY: Alan Liss, 1987:5–8.\nStrathy JH, Molgaard CA, Coulam CB, Melton LJ III. 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Sci. 20, 762–770 (2013). https://doi.org/10.1177/1933719112466307\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719112466307","source_license":"CC0","license_restricted":false}