The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis

Tahereh Arablou, Naheed Aryaeian, Sepideh Khodaverdi, Roya Kolahdouz‐Mohammadi, Roya Kolahdouz-Mohammadi, Zahra Moradi, Nesa Rashidi, Ali‐Akbar Delbandi, Ali-Akbar Delbandi
Scientific reports · 2021 · vol. 11(1) , pp. 6054 · doi:10.1038/s41598-021-85512-y · PMID:33723310 · PMC7961000 · W3138245363
article OA: gold CC0 ⤵ 25 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Resveratrol treatment reduced VEGF, TGF-β, and MMP-9 gene and protein expression in ectopic and eutopic endometrial stromal cells from women with endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated whether resveratrol alters angiogenesis- and invasion-related signaling in endometrial stromal cells by measuring VEGF, TGF-β, and MMP-9 gene and protein expression. Ectopic (EESCs) and eutopic (EuESCs) endometrial stromal cells from women with peritoneal endometriosis (stage III–IV; n=13 and 8) and control endometrial stromal cells from non-endometriotic patients (n=11) were exposed to 100 µM resveratrol and evaluated at 6, 24, and 48 hours using real-time PCR and ELISA; the paper reports higher baseline VEGF and MMP-9 in EESCs than in EuESCs and controls, and resveratrol decreased VEGF and MMP-9 expression across all cell types and decreased TGF-β expression in EESCs and EuESCs. A limitation explicitly described in the methods is that some ectopic samples were excluded due to culture contamination, improper pathology results, or failure to obtain the desired cells. This paper is centrally about endometriosis — specifically, it tests how resveratrol changes VEGF, TGF-β, and MMP-9 expression in ectopic and eutopic endometrial stromal cells from women with endometriosis.

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Abstract

Resveratrol is a phytochemical with anti-angiogenic, anti-inflammatory, and antioxidant properties. The present study has evaluated the effect of resveratrol on the expression of vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β) and matrix metalloproteinase-9 (MMP-9) as factors related to endometriosis progression. Thirteen eutopic (EuESCs) and 8 ectopic (EESCs) endometrial stromal cells from women with endometriosis and 11 control endometrial stromal cells (CESCs) were treated with resveratrol (100 µM) for 6, 24 and 48 h. The gene and protein expression levels of VEGF, TGF-β, and MMP-9 were measured using real-time PCR and ELISA methods, respectively. Results showed that the basal gene and protein expression of VEGF and MMP-9 were higher in EESCs compared to EuESCs and CESCs (P < 0.01 to < 0.001 and P < 0.05 to < 0.01 respectively). Also, resveratrol treatment decreased the gene and protein expression of VEGF and MMP-9 in EuESCs, EESCs and CESCs (P < 0.05 to < 0.01 and P < 0.05 to < 0.01 respectively) and gene and protein expression of TGF-β in EESCs and EuESCs (P < 0.05 to < 0.01). The effect of resveratrol in reduction of VEGF gene expression was statistically more noticeable in EESCs compared to EuESCs and CESCs (P < 0.05). According to the findings, resveratrol may ameliorate endometriosis progression through reducing the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells (ESCs).

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Regulation Matrix Metalloproteinase 9 Resveratrol Transforming Growth Factor beta Vascular Endothelial Growth Factor A Adult Cells, Cultured Dose-Response Relationship, Drug Endometriosis Endometriosis Female Gene Expression Regulation Humans Matrix Metalloproteinase 9 Middle Aged Resveratrol Stromal Cells Stromal Cells Stromal Cells

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