Local Production of Interleukins and Growth Factors in External Genital Endometriosis

S. А. Selkov, S A Sel'kov, Sel'kov SA, Solodovnikova NG, N G Solodovnikova, Н. Г. Солодовникова, О. В. Павлов, O V Pavlov, Dariko A. Niauri, D A Niauri
Bulletin of experimental biology and medicine · 2005 · vol. 139(4) , pp. 444–447 · doi:10.1007/s10517-005-0318-y · PMID:16027877 · W1991126880
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-26 ⓘ

This study investigated the in vitro production of ILs and growth factors by endometrial tissues and endometriotic foci in patients with external genital endometriosis, finding increased IL-1β, IL-2, IL-6, and VEGF in severe endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

The study examined, in vitro, local secretion of interleukins (IL-1β, IL-2, IL-6) and growth factors (VEGF, IGF-I, TGFβ) by endometrial tissues and endometrioid heterotopies from patients with external genital endometriosis across different severities. In the endometrium, production of IL-1β, IL-2, and IL-6 and secretion of VEGF increased with severe disease, while TGFβ secretion decreased; in endometrioid foci, hyperproduction of IL-2 and IL-6 and VEGF with decreased TGFβ production was reported. The authors attribute these findings to a local cytokine imbalance and increased proliferative activity of endometrial cells, but a key limitation is that the work was conducted on tissue cultures rather than directly assessing in vivo mechanisms. This paper is centrally about endometriosis — it focuses on local production of interleukins and growth factors in external genital endometriosis.

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Abstract

Secretion of some IL and growth factors (VEGF, IGF-I, TGFbeta) by endometrial tissues and endometrioid heterotopies was studied in vitro in patients with external genital endometriosis of different severity. The production of IL-1beta, IL-2, IL-6, and VEGF in the endometrium increased in severe external genital endometriosis, while the secretion of TGFbeta decreased; hyperproduction of IL-2, IL-6, VEGF and decreased production of TGFbeta were detected in endometrioid foci. Presumably, local cytokine imbalance and increased proliferative activity of endometrial cells are involved in the mechanisms of formation and functioning of endometrioid foci.
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Abstract

Secretion of some IL and growth factors (VEGF, IGF-I, TGFβ) by endometrial tissues and endometrioid heterotopies was studied in vitro in patients with external genital endometriosis of different severity. The production of IL-1β, IL-2, IL-6, and VEGF in the endometrium increased in severe external genital endometriosis, while the secretion of TGFβ decreased; hyperproduction of IL-2, IL-6, VEGF and decreased production of TGFβ were detected in endometrioid foci. Presumably, local cytokine imbalance and increased proliferative activity of endometrial cells are involved in the mechanisms of formation and functioning of endometrioid foci. Similar content being viewed by others

References

L.V. Adamyan and V. I. Kulakov, Endometriosis [in Russian], Moscow (1998). Yu. S. Antsiferova, N. Yu. Sotnikova, L. V. Poiseeva, and A. L. Shor, Akush. Ginekol., No. 5, 41–44 (2003). N. I. Kondrikov and L. V. Adamyan, Ibid., No. 2, 9–12 (1999). R. V. Pavlov, V. A. Aksenenko, and S. A. Sel’kov, Zh. Akush. Zhensk. Bol., No. 1, 74–77 (2002). M. A. Pal’tsev and A. A. Ivanov, Cell-to-Cell Interactions [in Russian], Smolensk (1995). A. V. Pomortsev, G. V. Gudkov, and A. M. Degtyarev, Akush. Ginekol., No. 4, 35–41 (2002). S. A. Sel’kov, N. L. Kramareva, O. V. Pavlov, and M. I. Yarmolinskaya, Zh. Akush. Zhensk. Bol., 51, No.3, 57–62 (2002). S. A. Sel’kov, M. I. Yarmolinskaya, V. V. Grigor’eva, et al., Vestn. Ros. Ass. Akush.-Ginek., No. 3, 40–43 (1997). A. S. Simbirtsev, Tsitokiny i Vospalenie, 1, No.1, 9–17 (2002). I. S. Freidlin and A. A. Totolyan, Immune System Cells [in Russian], Vol. 3–4, St. Petersburg (2001). T. Cohen, D. Nahari, L. W. Cerem, et al., J. Biol. Chem., 271, 736–741 (1996). S. M. Hyder and G. M. Stancel, Mol. Endocrinol., 13, No.6, 806–811 (1999). M. Nissole, F. Casanas-Roux, V. Anaf, et al., Fertil. Steril., 59, 681–684 (1993). Author information Authors and Affiliations Corresponding author Additional information __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 4, pp. 439–42, April, 2005 Rights and permissions About this article Cite this article Sel’kov, S.A., Solodovnikova, N.G., Pavlov, O.V. et al. Local Production of Interleukins and Growth Factors in External Genital Endometriosis. Bull Exp Biol Med 139, 444–447 (2005). https://doi.org/10.1007/s10517-005-0318-y Received: Issue date: DOI: https://doi.org/10.1007/s10517-005-0318-y

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endometriosis

MeSH descriptors

Endometriosis Growth Substances Interleukins Adult Endometriosis Enzyme-Linked Immunosorbent Assay Female Growth Substances Humans Interleukins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

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