S. А. Selkov

External genital endometriosis is a chronic inflammatory disease affecting 10% of women of reproductive age, characterized by neoangiogenesis in endometriotic implants, which is controlled by a variety of factors. Recently, a great deal of …

Endometriosis is a chronic recurrent disease with insufficiently studied pathogenesis. Endometriosis is known to share similar features with tumors. Thus, the outgrowth of endometrium-like tissue outside the uterus is the main feature of th…

Angiogenesis is the development of new blood vessels from pre-existing ones. It is a complex multifaceted process that is essential for the adequate functioning of human organisms. The investigation of angiogenesis is conducted using variou…

Endometriosis is a chronic gynecological disease, which poses a serious problem in terms of diagnosis and treatment. Despite decades of research, there are no specific signs and symptoms and no blood tests to clinically confirm the diagnosi…

The article presents the results of the investigation of cytokine production by endometrioid heterotopias in organotypic cultivation in comparison with the cell secretory activity of peritoneal fluid and endometrial tissue in women with ext…

Эндометриоз — это заболевание, характеризующееся иммунной дисфункцией на различных уровнях: от нарушений в передаче сигналов цитокинами к изменениям в популяциях клеток иммунной системы, в результате чего развивается персистирующая воспали…

The aim of this research was to assess the proliferative activity of Natural Killer Cells (NK cells) from Peripheral Blood Mononuclear Cells (PBMCs) in the presence of trophoblast cells in women with a history of recurrent miscarriages. We …

Hypothesis/aims of study. Endometriosis is the main cause of infertility and social maladjustment in women, caused by the presence of inflammatory endometriotic implants outside the uterus. A number of chemokines, including interferons, com…

Angiogenesis is a process of new blood vessel formation, which plays a significant role in carcinogenesis and the development of diseases associated with pathological neovascularization. An important role in the regulation of angiogenesis b…

The article represents the author’s original definition of genital endometriosis, emphasizing the main pathogenetic feature of the disease — violation of regulatory mechanisms, underlying in its development and characterizing diversity of i…

Background. Deep infiltrative endometriosis (DIE) is characterized by the invasion of endometriosis lesions in tissues and organs to a depth of over 5 mm. In recent years, the proportion of infiltrative forms of endometriosis has been stead…

To date, pelvic endometriosis is one of the most widespread gynecological disorders in the women of reproductive age. It has been known that pelvic endometriosis is a progressive disease occuring on the background of chronic estrogen-depend…

Endometriosis is a disease accompanied by development of heterotopic endometrial foci at the peritoneum, proliferation of endothelial cells, and inflammatory reaction. Aiming to specify the dynamics of inflammatory process in endometriosis …

The article presents the results of intraperitoneal administration of recombinant rat interferon-α to twenty Wistar rats with experimentally induced endometriosis. The following criteria of treatment efficiency were applied: presence of ect…

Results of recombinant interleukine-2 (Ronkoleukine) antirecurrent treatment of external genital endometriosis (EGE) during postsurgical time are represented in the report. Basic immunological characteristics are shown to return to normal v…

Intraperitoneal injection of rat IFN-alpha and human IL-2 to rats with experimental endometriosis led to complete regression of endometrioid heterotopies in 50 and 60% cases, respectively. Retention of the endometrioid epithelium resulted i…

65535 Endometriosis is a pelvic pathological process, when endometriotic lesions require neovascularisation to establish, proliferate and invide inside the peritoneal cavity. We analyzed the role of main angiogenic factors VEGF and bFGF in …

The article represents the results of intra-abdominal administration of recombinant human interleukine-2 (roncoleukine) to 20 rat models (Wistar line rats) of endometriosis. The treatment efficacy criteria applied were: presence of ectopic …

Secretion of some IL and growth factors (VEGF, IGF-I, TGFbeta) by endometrial tissues and endometrioid heterotopies was studied in vitro in patients with external genital endometriosis of different severity. The production of IL-1beta, IL-2…

The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endomet…

The article represents the authors data, gained during studies of systemic and local mechanisms of regulation of immune processes in pathogenesis of external genital endometriosis. Research was carried out into spectrum and production of so…

Introduction: Various components of immune system take part in pathogenesis of endometriosis. Their role might be paramount or minor during different periods of the disease.