Comparative efficiency of intraperitoneal interleukine-2 and interferon-α in rats with experimental endometriosis

S A Sel'kov, Sel'kov SA, S. А. Selkov, Pavlov RV, R V Pavlov, Р. В. Павлов
Bulletin of experimental biology and medicine · 2007 · vol. 143(3) , pp. 363–367 · doi:10.1007/s10517-007-0113-z · PMID:18225765 · W2025184137
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-28 ⓘ

Intraperitoneal interleukine-2 and interferon-α in rats with experimental endometriosis induced complete lesion regression in 60% and 50% of cases, respectively, and reduced proliferative activity and inflammation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This paper compared the effects of intraperitoneal interleukin-2 versus interferon-α in rats with experimentally induced endometriosis, using injections of rat IFN-α and human IL-2 and assessing regression of endometrioid heterotopies. Complete regression occurred in 50% of rats treated with IFN-α and in 60% treated with IL-2, while in cases with retained endometrioid epithelium both treatments significantly reduced proliferative activity, vascularization, and the number of macrophages in leukocytic infiltration. A key limitation is that the provided information does not describe sample size, dosing regimen, randomization/blinding, or the full methods used to quantify the histologic and inflammatory endpoints. This paper is centrally about endometriosis — it directly tests intraperitoneal IL-2 and IFN-α for regression of experimental endometrioid heterotopies in rats.

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Abstract

Intraperitoneal injection of rat IFN-alpha and human IL-2 to rats with experimental endometriosis led to complete regression of endometrioid heterotopies in 50 and 60% cases, respectively. Retention of the endometrioid epithelium resulted in a significant reduction of proliferative activity of its cells, degree of vascularization, and number of macrophages in the leukocytic infiltration of endometrioid heterotopies.
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Abstract

Intraperitoneal injection of rat IFN-α and human IL-2 to rats with experimental endometriosis led to complete regression of endometrioid heterotopies in 50 and 60% cases, respectively. Retention of the endometrioid epithelium resulted in a significant reduction of proliferative activity of its cells, degree of vascularization, and number of macrophages in the leukocytic infiltration of endometrioid heterotopies.

References

G. G. Avtandilov, Computer-Aided Microtelephotometry in Diagnostic Histocytopathology [in Russian], Moscow (1996). L. V. Adamyan and V. I. Kulakov, Endometriosis: Manual for Physicians [in Russian], Moscow (1998). G. M. Makhmudova and A. V. Popov, Ros. Vestn. Akush. Ginekol., No. 2, 27–30 (2004). S. A. Sel’kov, N. L. Kramareva, O. V. Pavlov, and M. I. Yarmolinskaya, Zh. Akush. Zhensk. Bol., 51, No. 3, 57–62 (2002). M. I. Yarmolinskaya, V. V. Grigoryeva, V. B. Anikin, et al., Immunol. Reprod., 6, Nos. 3–5, 394–395 (2004). M. Berkkanoglu and A. Arici, Am. J. Reprod. Immunol., 50, No. 1, 48–59 (2003). W. Paul Dmowski and D. P. Braun, Best Pract. Res. Clin. Obstet. Gynaecol., 18, No. 2, 245–263 (2004). M. Y. Wu and H. N. Ho, Am. J. Reprod. Immunol., 49, No. 5, 285–296 (2003). Author information Authors and Affiliations Additional information __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 3, pp. 335–339, March, 2007 Rights and permissions About this article Cite this article Sel’kov, S.A., Pavlov, R.V. Comparative efficiency of intraperitoneal interleukine-2 and interferon-α in rats with experimental endometriosis. Bull Exp Biol Med 143, 363–367 (2007). https://doi.org/10.1007/s10517-007-0113-z Received: Issue date: DOI: https://doi.org/10.1007/s10517-007-0113-z

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interferon Type I Interleukin-2 Animals Cell Proliferation Cell Proliferation Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Humans Immunologic Factors Immunologic Factors Injections, Intraperitoneal Interferon Type I Interleukin-2 Leukocytes

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