Lactobacillus gasseri OLL2809 inhibits development of ectopic endometrial cell in peritoneal cavity via activation of NK cells in a murine endometriosis model

Hiroyuki Itoh, Ito H, Toshihiro Sashihara, Akira Hosono, Shuichi Kaminogawa, Masayuki Uchida
Cytotechnology · 2011 · vol. 63(2) , pp. 205–210 · doi:10.1007/s10616-011-9343-z · PMID:21409454 · PMC3080482 · W2002796281
article OA: bronze CC0 ⤵ 36 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Oral administration of heat-killed Lactobacillus gasseri OLL2809 suppressed endometriosis development in mice by enhancing NK cell activity through increased IL-2 and NKp46 gene expression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper tested whether oral administration of heat-killed Lactobacillus gasseri OLL2809, a probiotic lactobacillus known to stimulate IL-12 production, suppresses development of ectopic endometriotic lesions in a murine endometriosis model. Mice received L. gasseri OLL2809 for 21 consecutive days, resulting in a reduction of ectopic endometriotic lesion development to an extent similar to prior IL-12 effects, alongside increased transcription of IL-2 and NK cell triggering receptor 1 in peritoneal cells and evidence consistent with enhanced splenic NK cell cytotoxicity and NK-cell activation. The authors did not report in the provided text any direct NK-cell depletion or other specificity experiments to rule out non-NK pathways. Relevance to endometriosis: the study directly evaluates L. gasseri OLL2809 as an inhibitor of ectopic endometrial lesion development via activation of NK cells in a murine endometriosis model.

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endometriosis

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