New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

Nerea M. Molina, Alberto Sola‐Leyva, María José Sáez‐Lara, Julio Plaza‐Díaz, Aleksandra Tubić-Pavlović, Bárbara Romero, Barbara Romero, Ana Clavero, Juan Mozas‐Moreno, Juan Torres Fontes, Juan Fontes, Signe Altmäe
Biomolecules · 2020 · vol. 10(4) , pp. 593 · doi:10.3390/biom10040593 · PMID:32290428 · PMC7226034 · W3015251032
review OA: gold CC0 ⤵ 45 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review outlines identified endometrial microbes, current treatments for dysbiosis, and future possibilities like probiotics, prebiotics, and microbial transplants for modifying uterine microbial composition.

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Abstract

Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Nevertheless there is no unified protocol for assessing the endometrial dysbiosis and no optimal treatment protocol for the established dysbiosis. With this review we outline the microbes (mostly bacteria) identified in the endometrial microbiome studies, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometrium Uterus Disease Endometrium Female Humans Microbiota Uterine Diseases Uterine Diseases Uterine Diseases Uterine Diseases Uterus

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Cited by (45)

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License: CC0 · commercial use OK