Alberto Sola‐Leyva

BACKGROUND: Emerging evidence suggests microbial dysbiosis may contribute to gynaecological pathologies, including endometriosis and recurrent implantation failure (RIF). The vaginal microbiome is well-characterised, with Lactobacillus-domi…

Rapid advances in microbiome research are transforming our understanding of human health and disease, with growing focus on the female reproductive tract as a critical but understudied niche. Evidence for a local microbiome largely derives …

Study questionDoes the analysis of endometrial microbes provide the same information when using DNA or RNA sequencing-based techniques?Summary answerDNA vs RNA-based microbial analysis techniques demonstrated significant microbial compositi…

Abstract Background Endometriosis is a complex, estrogen-dependent disease with a strong genetic component. Although genome-wide association studies (GWAS) have identified multiple susceptibility loci, most associated variants reside in non…

Study questionDoes the molecular composition of uterine fluid extracellular vesicles (UF-EVs) reflect endometrial tissue changes across the menstrual cycle?Summary answerConcordance between endometrial tissue and UF-EVs exists on miRNA and …

Abstract Study question Does the microbial composition along the female reproductive tract (vagina, cervix and uterus) differ between women with and without endometriosis? Summary answer Slight differences in the microbial composition along…

INTRODUCTION: Several metabolite classes have been identified in human endometrium, including lipids, nucleotides, amino acids, organic acids, and sugars. The first studies suggest the importance of metabolites in endometrial functions, as …

Abstract Study question Are there differential transcriptomic profiles of the receptive phase endometria in infertile women with different infertility diagnoses? Summary answer Endometrium-related pathologies such as endometriosis and RIF s…

Study questionWhich genes regulate receptivity in the epithelial and stromal cellular compartments of the human endometrium, and which molecules are interacting in the implantation process between the blastocyst and the endometrial cells?Su…

Abstract Study question What is the entire metabolomic profile of receptive-phase human endometrium and does the metabolic composition differ between women with different infertility diagnosis? Summary answer Human endometrium contains 925 …

Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships rem…