Additional file 1 of Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain

Jimenez, Nicole, Norton, Taylor, Diadala, Gurbeen, Bell, Emerald, Valenti, Michelle, Farland, Leslie V., Mahnert, Nichole, Herbst-Kralovetz, Melissa M.
2024 · doi:10.6084/m9.figshare.26745167.v1 · W6977540594
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study analyzed vaginal and rectal microbiome composition, diversity, and abundance in patients with chronic pelvic pain, endometriosis, and other gynecologic conditions, correlating microbial findings with immune markers.

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Abstract

Additional file 1: Figure S1: Post-operative co-occurring conditions amongst disease groups of chronic pelvic pain, chronic pelvic pain with endometriosis, and surgical controls. Figure S2: Vaginal Lactobacillus abundances across diagnosis groups. Figure S3: Microbial diversity of patients diagnosed with chronic pelvic pain, chronic pelvic pain with endometriosis, and surgical controls. Figure S4: Differentially abundant taxa of CPP, CPP-Endo compared to surgical controls. Figure S5: Differentially abundant taxa of CPP-Endo compared to CPP. Figure S6: Cluster metadata analysis from hierarchical heatmap of immune data. Figure S7: Cytokine differences between hierarchical heatmap for cluster 1 and cluster 2. Figure S8: Microbial alpha-diversity of patients diagnosed with endometriosis-by-endometriosis stage and location in vaginal and rectal samples. Figure S9: Microbial beta-diversity of patients diagnosed with endometriosis-by-endometriosis stage and location in vaginal and rectal samples. Figure S10: Vaginal Lactobacillus abundances across endometriosis stage and location. Figure S11: Differentially abundant taxa of endometriosis stage 3/4 compared to endometriosis stage 1/2. Figure S12: Differentially abundant taxa of endometriosis location sites. Figure S13: Microbial alpha-diversity of patients diagnosed with abnormal uterine bleeding, fibroids, and ovarian cysts in vaginal samples. Figure S14: Microbial alpha-diversity in rectal samples of patients diagnosed with abnormal uterine bleeding, fibroids, and ovarian cysts. Figure S15: Microbial beta-diversity of patients diagnosed with abnormal uterine bleeding, fibroids, and ovarian cysts in vaginal and rectal samples. Figure S16: Vaginal Lactobacillus abundances across co-occurring gynecologic conditions. Figure S17: HeatTree identifies differentially abundant taxa amongst co-occurring conditions: abnormal uterine bleeding, fibroids, and ovarian cysts in vaginal samples. Figure S18: HeatTree identifies differentially abundant taxa amongst co-occurring conditions: abnormal uterine bleeding, fibroids, and ovarian cysts in rectal samples. Figure S19: Vaginal taxa profiles of co-occurring condition: abnormal uterine bleeding, fibroids, and ovarian cysts in CPP cohort. Figure S20: Rectal taxa profiles of co-occurring condition: abnormal uterine bleeding, fibroids, and ovarian cysts in CPP cohort. Figure S21: Microbial diversity of patients diagnosed with heavy menstrual bleeding and irregular menstrual bleeding in vaginal and rectal samples. Figure S22: Vaginal Lactobacillus abundances across menstrual bleeding symptoms. Figure S23: Differentially abundant taxa of heavy menstrual bleeding. Figure S24: Differentially abundant taxa of irregular menstrual bleeding. Figure S25: Microbial diversity of blood present in vaginal samples. Figure S26: Differentially abundant taxa of blood observed in the vaginal sample. Figure S27: Immune Protein concentrations comparisons of heavy and irregular menstrual bleeding and blood within the sample. Figure S28: Heatmap of differentially abundant taxa of blood observed in vaginal samples and correlation to immune markers.

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Condition tags

endometriosischronic_pelvic_pain

Citation neighborhood

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References (96)

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