Inflammatory cytokines IL-6, IL-10, IL-13, TNF-α and peritoneal fluid flora were associated with infertility in patients with endometriosis.

Wang Xm, X-M Wang, Z-Y Ma, Ma ZY, Song N, Nan Song, N Song
European review for medical and pharmacological sciences · 2018 · vol. 22(9) , pp. 2513–2518 · doi:10.26355/eurrev_201805_14899 · PMID:29771400 · W2978189823
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Inflammatory cytokines IL-6, IL-10, IL-13, and TNF-α, along with peritoneal fluid flora composition, were found to be correlated with infertility in patients diagnosed with endometriosis.

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The paper investigated whether inflammatory cytokines (IL-6, IL-10, IL-13, and TNF-α) and peritoneal fluid bacterial flora are associated with infertility in patients with endometriosis, comparing 55 endometriosis patients with infertility to 30 non-endometriosis, non-infertility controls. Using ELISA to measure cytokine levels, flow-related white blood cell counts in peritoneal fluid, and Ion Torrent PGM sequencing to profile microbial composition, the authors found higher peritoneal white cell measures and higher IL-6, IL-10, IL-13, and TNF-α levels in the endometriosis-with-infertility group than controls (p<0.05), while Proteobacteria and Firmicutes dominated in both groups. Logistic regression showed significant correlations between these inflammatory factors and endometriosis complicated with infertility. This paper is centrally about endometriosis — it examines peritoneal inflammatory cytokines and microbiota associations with infertility in endometriosis patients.

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Abstract

OBJECTIVE: To investigate the correlations of inflammatory factors, interleukin-6 (IL-6), IL-10, IL-13 and tumor necrosis factor-α (TNF-α), and composition of bacterial flora in the peritoneal fluid with infertility in endometriosis patients. PATIENTS AND METHODS: A total of 55 patients diagnosed with endometriosis and infertility in the Gynecology Clinic of our hospital from June 2014 to July 2017 were selected as observation group, and another 30 non-endometriosis and non-infertility patients were enrolled as control group. The peritoneal fluid was extracted from patients in both groups, and the total white cell count and the percentage of leukocyte subset were determined. The total genome deoxyribonucleic acid (DNA) of microorganisms in peritoneal fluid was extracted, and the composition of microorganisms was analyzed using the Ion Torrent PGM platform (BGI). The levels of IL-6, IL-10, IL-13, and TNF-α in peritoneal fluid were detected via enzyme-linked immunosorbent assay (ELISA). Moreover, the correlations of inflammatory factors in the peritoneal fluid with endometriosis complicated with infertility were analyzed via Logistic regression analysis. RESULTS: The total white cell count, monocytes, neutrophils, eosinophils and basophils in endometriosis patients complicated with infertility were significantly higher than those in control group (p<0.05). Results of ELISA showed that the levels of IL-6, IL-10, IL-13, and TNF-α in peritoneal fluid of endometriosis patients complicated with infertility were significantly higher than those in control group (p<0.05). In peritoneal fluid of patients in both groups, Proteobacteria and Firmicutes were mainly dominated, followed by Actinobacillus, Bacteroidetes, Fusobacteria and Tenericutes, and there was no significant difference in the Eumycota between the two groups (p>0.05). Logistic regression analysis results showed that there were significant correlations of inflammatory factors (IL-6, IL-10, IL-13, and TNF-α) with endometriosis complicated with infertility. CONCLUSIONS: There are many kinds of Eumycota in the peritoneal fluid of endometriosis patients complicated with infertility, but they are not the main pathogenic factors. Inflammatory factors (IL-6, IL-10, IL-13, and TNF-α) can be used as important reference indexes for the diagnosis of endometriosis complicated with infertility.
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Objective

To investigate the correlations of inflammatory factors, interleukin-6 (IL-6), IL-10, IL-13 and tumor necrosis factor-α (TNF-α), and composition of bacterial flora in the peritoneal fluid with infertility in endometriosis patients. PATIENTS AND METHODS: A total of 55 patients diagnosed with endometriosis and infertility in the Gynecology Clinic of our hospital from June 2014 to July 2017 were selected as observation group, and another 30 non-endometriosis and non-infertility patients were enrolled as control group. The peritoneal fluid was extracted from patients in both groups, and the total white cell count and the percentage of leukocyte subset were determined. The total genome deoxyribonucleic acid (DNA) of microorganisms in peritoneal fluid was extracted, and the composition of microorganisms was analyzed using the Ion Torrent PGM platform (BGI). The levels of IL-6, IL-10, IL-13, and TNF-α in peritoneal fluid were detected via enzyme-linked immunosorbent assay (ELISA). Moreover, the correlations of inflammatory factors in the peritoneal fluid with endometriosis complicated with infertility were analyzed via Logistic regression analysis.

Results

The total white cell count, monocytes, neutrophils, eosinophils and basophils in endometriosis patients complicated with infertility were significantly higher than those in control group (p<0.05). Results of ELISA showed that the levels of IL-6, IL-10, IL-13, and TNF-α in peritoneal fluid of endometriosis patients complicated with infertility were significantly higher than those in control group (p<0.05). In peritoneal fluid of patients in both groups, Proteobacteria and Firmicutes were mainly dominated, followed by Actinobacillus, Bacteroidetes, Fusobacteria and Tenericutes, and there was no significant difference in the Eumycota between the two groups (p>0.05). Logistic regression analysis results showed that there were significant correlations of inflammatory factors (IL-6, IL-10, IL-13, and TNF-α) with endometriosis complicated with infertility.

Conclusions

There are many kinds of Eumycota in the peritoneal fluid of endometriosis patients complicated with infertility, but they are not the main pathogenic factors. Inflammatory factors (IL-6, IL-10, IL-13, and TNF-α) can be used as important reference indexes for the diagnosis of endometriosis complicated with infertility. Free PDF DownloadThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License To cite this article X.-M. Wang, Z.-Y. Ma, N. Song Inflammatory cytokines IL-6, IL-10, IL-13, TNF-α and peritoneal fluid flora were associated with infertility in patients with endometriosis Eur Rev Med Pharmacol Sci Year: 2018 Vol. 22 - N. 9 Pages: 2513-2518 DOI: 10.26355/eurrev_201805_14899 Publication History Published online: 11 May 2018

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Infertility, Female Infertility, Female Inflammation Mediators Adult Ascitic Fluid Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Endometriosis Female Fertility Humans Infertility, Female Infertility, Female

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