Clinical indicators and reproductive tract microbiota abnormalities indicate the occurrence of endometriosis

Xiaoqing Li, Cong Chen, Yuanyuan Zheng, Wenjing Lin, Hongping Zhang, Qionghui Pan
In: Research Square · 2024 · doi:10.21203/rs.3.rs-3806951/v1 · W4390545710
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Endometriosis patients exhibited distinct vaginal and cervical microbiota, with specific bacterial genera correlating with clinical pain indicators and antibody levels.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This preprint studied 35 women (17 with endometriosis and 18 healthy controls) comparing clinical indicators plus vaginal and cervical microbiota from cervical and vaginal secretions analyzed by 16S rRNA V3–V4 high-throughput sequencing. Women with endometriosis showed higher vaginal and cervical microbial diversity measures (e.g., higher Chao1 and Shannon indices) and distinct taxa, with specific genera correlating with symptoms and biomarkers: Romboutsia, Ruminococcus, Phascolarctobacterium, and Olsenella positively correlated with VAS pain, while Mobiluncus negatively correlated with VAS, and Lactobacillus (with other taxa) correlated with thyroid peroxidase antibody indices. The paper explicitly notes a major limitation that it is a preprint and not peer reviewed. This paper is centrally about endometriosis — it links reproductive tract clinical indicators and vaginal/cervical microbiota differences to the occurrence of endometriosis.

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Outcome instruments

VAS-pain

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

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