Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Camila Hernandes, Paola Silveira, Paola Paz Silveira, Aline Fernanda Rodrigues Sereia, Ana Paula Christoff, Helen Mendes, Luiz Felipe Valter de Oliveira, Sergio Podgaec, Sérgio Podgaec
Diagnostics · 2020 · vol. 10(3) , pp. 163 · doi:10.3390/diagnostics10030163 · PMID:32192080 · W3012093490
article OA: gold CC0 ⤵ 59 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study compared microbiome profiles from vaginal fluid, endometrium, and endometriotic lesions, finding similar bacterial composition overall but a distinct profile in deep lesions with less *Lactobacillus* and more *Alishewanella*, *Enterococcus*, and *Pseudomonas*.

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Abstract

This work aimed to identify and compare the bacterial patterns present in endometriotic lesions, eutopic endometrium and vaginal fluid from endometriosis patients with those found in the vaginal fluid and eutopic endometrium of control patients. Vaginal fluid, eutopic endometrium and endometriotic lesions were collected. DNA was extracted and the samples were analyzed to identify microbiome by high-throughput DNA sequencing of the 16S rRNA marker gene. Amplicon sequencing from vaginal fluid, eutopic endometrium and endometriotic lesion resulted in similar profiles of microorganisms, composed most abundantly by the genus Lactobacillus, Gardnerella, Streptococcus and Prevotella. No significant differences were found in the diversity analysis of microbiome profiles between control and endometriotic patients; however deep endometriotic lesions seems to present different bacterial composition, less predominant of Lactobacillus and with more abundant Alishewanella, Enterococcus and Pseudomonas.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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