Serum Polyunsaturated Fatty Acids and Endometriosis

Margaret M Hopeman, Joan K Riley, Antonina I Frolova, Hui Jiang, Emily S Jungheim
Reproductive sciences (Thousand Oaks, Calif.) · 2014 · vol. 22(9) , pp. 1083–1087 · doi:10.1177/1933719114565030 · PMID:25539770 · PMC5933167 · W2092315414
article OA: closed CC0 ⤵ 36 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study found that women with higher serum EPA levels were significantly less likely to have endometriosis, while no such association was observed for other polyunsaturated fatty acids.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This cross-sectional study measured circulating polyunsaturated fatty acids in serum from 205 women undergoing in vitro fertilization and related specific and total n-3 and n-6 PUFA levels to clinical history of endometriosis using liquid chromatography coupled to tandem mass spectrometry and multivariable logistic regression. Women with high serum eicosapentaenoic acid (EPA) had lower odds of having endometriosis than women with low EPA (odds ratio 0.18, 95% confidence interval 0.04–0.78). The paper’s main limitation is its cross-sectional design, which cannot establish temporality or causality between serum PUFA levels and endometriosis status. This paper is centrally about endometriosis — it tests whether serum n-3/n-6 polyunsaturated fatty acid profiles, especially EPA, are associated with endometriosis in IVF patients.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Eicosapentaenoic Acid Endometriosis Fatty Acids, Omega-6 Adult Biomarkers Biomarkers Chromatography, High Pressure Liquid Cross-Sectional Studies Eicosapentaenoic Acid Endometriosis Endometriosis Endometriosis Fatty Acids, Omega-6 Female Humans Logistic Models Multivariate Analysis Prognosis Protective Factors Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (36)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:18:04.362919+00:00
License: CC0 · commercial use OK