The effects of oral nutritional supplements on endometriosis-related pain: A narrative review of clinical studies

Tamiris Julio; Bruna Alves Fenerich; Gabriela Halpern; Pedro Carrera-Bastos; Pedro Carrera‐Bastos; Eduardo Schor; Alexander Kopelman

doi:10.1016/j.jogoh.2024.102830

The effects of oral nutritional supplements on endometriosis-related pain: A narrative review of clinical studies

Tamiris Julio, Bruna Alves Fenerich, Gabriela Halpern, Pedro Carrera-Bastos, Pedro Carrera‐Bastos, Eduardo Schor, Alexander Kopelman

Journal of gynecology obstetrics and human reproduction · 2024 · vol. 53(10) , pp. 102830 · doi:10.1016/j.jogoh.2024.102830 · PMID:39067786 · W4401015657

review OA: closed CC0 ⤵ 4 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This narrative review synthesizes clinical studies examining how oral nutritional supplements impact endometriosis-related pain.

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Dietary Supplements Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Administration, Oral Administration, Oral

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References (100)

1,25‐Dihydroxy Vitamin D3 Modulates Endometriosis‐Related Features of Human Endometriotic Stromal Cells via openalex
Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain—A randomized double-blinded, placebo-controlled trial via openalex
Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain via openalex
Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion via openalex
Alteration of systemic and uterine endometrial immune populations in patients with endometriosis via openalex
Antioxidant supplementation reduces endometriosis-related pelvic pain in humans via openalex
A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine via openalex
A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1) via openalex
Body size and endometriosis: results from 20 years of follow-up within the Nurses' Health Study II prospective cohort via openalex
Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain via openalex
Comparison of dienogest effects upon 3,3′–diindolylmethane supplementation in models of endometriosis and clinical cases via openalex
Creating Solutions in Endometriosis: Global Collaboration through the World Endometriosis Research Foundation via openalex
Curcumin as anti-endometriotic agent: Implication of MMP-3 and intrinsic apoptotic pathway via openalex
Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway via openalex
Dietary supplements for treatment of endometriosis: A review. via openalex
Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study via openalex
Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies via openalex
Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model via openalex
Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate. via openalex
Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis via openalex
Effects of vitamin C on the outcome of in vitro fertilization–embryo transfer in endometriosis: A randomized controlled study via openalex
Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial via openalex
Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial via openalex
Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why via openalex
Endometriosis: A Comprehensive Review via openalex
Endometriosis after menopause: physiopathology and management of an uncommon condition via openalex
Endometriosis and environmental factors: A critical review via openalex
Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options via openalex
Environmental Risk Factors for Endometriosis: An Umbrella Review of a Meta-Analysis of 354 Observational Studies With Over 5 Million Populations via openalex
Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility via openalex
Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation via openalex
Immunology of endometriosis via openalex
Impact of diet on pain perception in women with endometriosis: A systematic review via openalex
Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot study via openalex
Melatonin activity and receptor expression in endometrial tissue and endometriosis via openalex
Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight via openalex
Non-invasive diagnosis of endometriosis and moderate-severe endometriosis with serum CA125, endocan, YKL-40, and copeptin quadruple panel via openalex
Novel dietary supplement association reduces symptoms in endometriosis patients via openalex
Nutritional aspects related to endometriosis via openalex
Oxidative stress biomarkers in patients with endometriosis: systematic review via openalex
Oxidative stress‐related effects on various aspects of endometriosis via openalex
Pathogenesis of endometriosis: the genetic/epigenetic theory via openalex
Pelvic endometriosis and natural killer cell immunity via openalex
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis via openalex
Preliminary Study of Quercetin Affecting the Hypothalamic‐Pituitary‐Gonadal Axis on Rat Endometriosis Model via openalex
Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? via openalex
Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased via openalex
Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo via openalex
Receptivity, autophagy, and implantation in endometriosis; does antioxidant work? An experimental study via openalex
Recommendations for the Surgical Treatment of Endometriosis. Part 1: Ovarian Endometrioma†‡¶ via openalex
Reevaluating response and failure of medical treatment of endometriosis: a systematic review via openalex
Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells via openalex
Resveratrol impairs cellular mechanisms associated with the pathogenesis of endometriosis via openalex
Role of NK cells and HLA-G in endometriosis via openalex
Serum Polyunsaturated Fatty Acids and Endometriosis via openalex
Should Genetics Now Be Considered the Pre-eminent Etiologic Factor in Endometriosis? via openalex
The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain via openalex
The Combination of N‐Acetyl Cysteine, Alpha‐Lipoic Acid, and Bromelain Shows High Anti‐Inflammatory Properties in Novel In Vivo and In Vitro Models of Endometriosis via openalex
The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial via openalex
The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis via openalex
The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis via openalex
The endometrial immune environment of women with endometriosis via openalex
The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial via openalex
The modulating effects of vitamin D on the activity of β-catenin in the endometrium of women with endometriosis: a randomized exploratory trial via openalex
Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways via openalex
The relationship between endometriosis and diet via openalex
The role of the oxidative-stress in the endometriosis-related infertility via openalex
The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial via openalex
Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research via openalex
Vitamin D deficiency as a risk factor for endometriosis in Iranian women via openalex
What is the link between endometriosis and adiposity? via openalex
W6806417589 via openalex
W6810091695 via openalex
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W1951528568 via openalex
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W1988292100 via openalex
W1998806168 via openalex
W2003889668 via openalex
W2031114460 via openalex
W2033247060 via openalex
W2047362713 via openalex
W2061528612 via openalex
W2071351566 via openalex
W2076644494 via openalex
W2085922363 via openalex
W2090500595 via openalex
W2119624946 via openalex
W2128941372 via openalex
W2131956609 via openalex
W2134891742 via openalex
W2145753985 via openalex
W2154492492 via openalex
W2157510347 via openalex

Cited by (4)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-21T00:32:30.791253+00:00

License: CC0 · commercial use OK

[1] 1,25‐Dihydroxy Vitamin D3 Modulates Endometriosis‐Related Features of Human Endometriotic Stromal Cells via openalex

[2] Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain—A randomized double-blinded, placebo-controlled trial via openalex

[3] Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain via openalex

[4] Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion via openalex

[5] Alteration of systemic and uterine endometrial immune populations in patients with endometriosis via openalex

[6] Antioxidant supplementation reduces endometriosis-related pelvic pain in humans via openalex

[7] A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine via openalex

[8] A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1) via openalex

[9] Body size and endometriosis: results from 20 years of follow-up within the Nurses' Health Study II prospective cohort via openalex

[10] Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain via openalex

[11] Comparison of dienogest effects upon 3,3′–diindolylmethane supplementation in models of endometriosis and clinical cases via openalex

[12] Creating Solutions in Endometriosis: Global Collaboration through the World Endometriosis Research Foundation via openalex

[13] Curcumin as anti-endometriotic agent: Implication of MMP-3 and intrinsic apoptotic pathway via openalex

[14] Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway via openalex

[15] Dietary supplements for treatment of endometriosis: A review. via openalex

[16] Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study via openalex

[17] Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies via openalex

[18] Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model via openalex

[19] Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate. via openalex

[20] Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis via openalex

[21] Effects of vitamin C on the outcome of in vitro fertilization–embryo transfer in endometriosis: A randomized controlled study via openalex

[22] Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial via openalex

[23] Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial via openalex

[24] Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why via openalex

[25] Endometriosis: A Comprehensive Review via openalex

[26] Endometriosis after menopause: physiopathology and management of an uncommon condition via openalex

[27] Endometriosis and environmental factors: A critical review via openalex

[28] Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options via openalex

[29] Environmental Risk Factors for Endometriosis: An Umbrella Review of a Meta-Analysis of 354 Observational Studies With Over 5 Million Populations via openalex

[30] Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility via openalex

[31] Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation via openalex

[32] Immunology of endometriosis via openalex

[33] Impact of diet on pain perception in women with endometriosis: A systematic review via openalex

[34] <p>Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot study</p> via openalex

[35] Melatonin activity and receptor expression in endometrial tissue and endometriosis via openalex

[36] Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight via openalex

[37] Non-invasive diagnosis of endometriosis and moderate-severe endometriosis with serum CA125, endocan, YKL-40, and copeptin quadruple panel via openalex

[38] Novel dietary supplement association reduces symptoms in endometriosis patients via openalex

[39] Nutritional aspects related to endometriosis via openalex

[40] Oxidative stress biomarkers in patients with endometriosis: systematic review via openalex

[41] Oxidative stress‐related effects on various aspects of endometriosis via openalex

[42] Pathogenesis of endometriosis: the genetic/epigenetic theory via openalex

[43] Pelvic endometriosis and natural killer cell immunity via openalex

[44] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[45] Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis via openalex

[46] Preliminary Study of Quercetin Affecting the Hypothalamic‐Pituitary‐Gonadal Axis on Rat Endometriosis Model via openalex

[47] Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? via openalex

[48] Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased via openalex

[49] Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo via openalex

[50] Receptivity, autophagy, and implantation in endometriosis; does antioxidant work? An experimental study via openalex

[51] Recommendations for the Surgical Treatment of Endometriosis. Part 1: Ovarian Endometrioma†‡¶ via openalex

[52] Reevaluating response and failure of medical treatment of endometriosis: a systematic review via openalex

[53] Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells via openalex

[54] Resveratrol impairs cellular mechanisms associated with the pathogenesis of endometriosis via openalex

[55] Role of NK cells and HLA-G in endometriosis via openalex

[56] Serum Polyunsaturated Fatty Acids and Endometriosis via openalex

[57] Should Genetics Now Be Considered the Pre-eminent Etiologic Factor in Endometriosis? via openalex

[58] The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain via openalex

[59] The Combination of N‐Acetyl Cysteine, Alpha‐Lipoic Acid, and Bromelain Shows High Anti‐Inflammatory Properties in Novel <i>In Vivo</i> and <i>In Vitro</i> Models of Endometriosis via openalex

[60] The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial via openalex

[61] The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis via openalex

[62] The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis via openalex

[63] The endometrial immune environment of women with endometriosis via openalex

[64] The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial via openalex

[65] The modulating effects of vitamin D on the activity of β-catenin in the endometrium of women with endometriosis: a randomized exploratory trial via openalex

[66] Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways via openalex

[67] The relationship between endometriosis and diet via openalex

[68] The role of the oxidative-stress in the endometriosis-related infertility via openalex

[69] The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial via openalex

[70] Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research via openalex

[71] Vitamin D deficiency as a risk factor for endometriosis in Iranian women via openalex

[72] What is the link between endometriosis and adiposity? via openalex

[73] W6806417589 via openalex

[74] W6810091695 via openalex

[75] W6839083382 via openalex

[76] W45120443 via openalex

[77] W6855823445 via openalex

[78] W1510960970 via openalex

[79] W1928608880 via openalex

[80] W1948740966 via openalex

[81] W1951528568 via openalex

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[86] W2031114460 via openalex

[87] W2033247060 via openalex

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[89] W2061528612 via openalex

[90] W2071351566 via openalex

[91] W2076644494 via openalex

[92] W2085922363 via openalex

[93] W2090500595 via openalex

[94] W2119624946 via openalex

[95] W2128941372 via openalex

[96] W2131956609 via openalex

[97] W2134891742 via openalex

[98] W2145753985 via openalex

[99] W2154492492 via openalex

[100] W2157510347 via openalex